Compounds for the treatment of HIV

1. A method for treating an HIV infection in a human, comprising administering a compound of formula I:

or a pharmaceutically acceptable salt thereof, to the human, wherein:

A is pyridinyl, pyrimidinyl, pyrazinyl or pyridazinyl, wherein any pyridinyl, pyrimidinyl, pyrazinyl, or pyridazinyl of A is substituted with one Z 1 group and optionally substituted with 1, 2, or 3 Z 2 groups;

B is absent; or B is —O − and the nitrogen to which the —O − group is attached is N + ;

W is —CR 3a R 3b —;

R 1 is a bicyclic-heteroaryl, tricyclic-heteroaryl, bicyclic-heterocycle or tricyclic-heterocycle, wherein any bicyclic-heteroaryl, tricyclic-heteroaryl, bicyclic-heterocycle or tricyclic-heterocycle of R 1 is optionally substituted with 1, 2, 3, 4, or 5 Z 3 groups;

R 2 is a 6-membered aryl, 5-membered heteroaryl or 6-membered heteroaryl, wherein any 6-membered aryl, 5-membered heteroaryl or 6-membered heteroaryl of R 2 is optionally substituted with 1, 2, or 3 Z 4 groups;

each R 3a and R 3b is independently selected from H, (C 1 -C 6 )alkyl, (C 1 -C 3 )haloalkyl, (C 1 -C 6 )heteroalkyl, heterocyclyl(C 1 -C 6 )alkyl-;

each Z 1 is independently selected from (C 2 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 3 -C 7 )carbocycle, (C 6 -C 20 )aryl, heteroaryl, heterocycle and —OR n1 , wherein any (C 3 -C 7 )carbocycle, (C 6 -C 20 )aryl, heteroaryl and heterocycle of Z 1 is optionally substituted with 1, 2, 3, 4, or 5 Z 1a or Z 1b groups and wherein any (C 2 -C 8 )alkyl, (C 2 -C 8 )alkenyl and (C 2 -C 8 )alkynyl of Z 1 is optionally substituted with 1, 2, 3, 4, or 5 Z 1a groups;

each Z 1a is independently selected from (C 3 -C 7 )carbocycle, (C 6 -C 20 )aryl, heteroaryl, heterocycle, halogen, —CN, —OR n2 , —OC(O)R p2 , —OC(O)NR q2 R r2 , —SR n2 , —S(O)R p2 , —S(O) 2 OH, —S(O) 2 R p2 , —S(O) 2 NR q2 R r2 , —NR q2 R r2 , —NR n2 COR p2 , —NR n2 CO 2 R p2 , —NR n2 CONR q2 R r2 , —NR n2 S(O) 2 R p2 , —NR n2 S(O) 2 OR p2 , —NR p2 S(O) 2 NR q2 R r2 , NO 2 , —C(O)R n2 , —C(O)OR n2 , —C(O)NR q2 R r2 and —S(O) 2 NR n2 COR p2 , wherein any (C 3 -C 7 )carbocycle, (C 6 -C 20 )aryl, heteroaryl and heterocycle of Z 1a is optionally substituted with 1, 2, 3, 4, or 5 Z 1c or Z 1d groups;

each Z 1b is independently selected from (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl and (C 2 -C 8 )alkynyl, wherein any (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl and (C 2 -C 8 )alkynyl of Z 1b is optionally substituted with 1, 2, 3, 4, or 5 Z 1c groups;

each Z 1c is independently selected from (C 3 -C 7 )carbocycle, (C 6 -C 20 )aryl, heteroaryl, heterocycle,

halogen, —CN, —OR n3 , —OC(O)R p3 , C(O)NR q3 R r3 , —SR n3 , —S(O)R p3 , —S(O) 2 OH, —S(O) 2 R p3 , —S(O) 2 NR q3 R r3 , —NR q3 R r3 , —NR n3 COR p3 , —NR n3 CO 2 R p3 , —NR n3 ONR q3 R r3 , —NR n3 S(O) 2 R p3 , —NR n3 S(O) 2 OR p3 , —NR n3 S(O 2 NR q3 R r3 , NO 2 , —C(O)R n3 , —C(O)OR n3 , —C(O)NR q3 R r3 , (C 6 -C 20 )haloaryl, haloheteroaryl, haloheterocycle and (C 1 -C 8 )heteroalkyl;

each Z 1d is independently selected from (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl and (C 1 -C 8 )haloalkyl;

each R n1 is independently selected from (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 3 -C 7 )carbocycle, heterocycle, heteroaryl and (C 6 -C 20 )aryl, wherein any (C 3 -C 7 )carbocycle, (C 6 -C 20 )aryl, heteroaryl and heterocycle of R n1 is optionally substituted with 1, 2, 3, 4, or 5 Z 1a or Z 1b groups, and wherein any (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl and (C 2 -C 8 )alkynyl of R n1 is optionally substituted with 1, 2, 3, 4, or 5 Z 1a groups;

each R n2 is independently selected from H, (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 3 -C 7 )carbocycle, heterocycle, heteroaryl and (C 6 -C 20 )aryl, wherein any (C 3 -C 7 )carbocycle, (C 6 -C 20 )aryl, heteroaryl and heterocycle of R n2 is optionally substituted with 1, 2, 3, 4, or 5 Z 1c or Z 1a groups, and wherein any (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl and (C 2 -C 8 )alkynyl of R n2 is optionally substituted with 1, 2, 3, 4, or 5 Z 1c groups;

each R p2 is independently selected from (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 3 -C 7 )carbocycle, heterocycle, heteroaryl and (C 6 -C 20 )aryl, wherein any (C 3 -C 7 )carbocycle, (C 6 -C 20 )aryl, heteroaryl and heterocycle of R p2 is optionally substituted with 1, 2, 3, 4, or 5 Z 1c or Z 1a groups, and wherein any (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl and (C 2 -C 8 )alkynyl of R p2 is optionally substituted with 1, 2, 3, 4, or 5 Z 1c groups;

R q2 and R r2 are each independently selected from H, (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 3 -C 7 )carbocycle, heterocycle, heteroaryl and (C 6 -C 20 )aryl, wherein any (C 3 -C 7 )carbocycle, (C 6 -C 20 )aryl, heteroaryl and heterocycle of R q2 or R r2 is optionally substituted with 1, 2, 3, 4, or 5 Z 1c or Z 1d groups, and wherein any (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl and (C 2 -C 8 )alkynyl of R q2 or R r2 is optionally substituted with 1, 2, 3, 4, or 5 Z 1c groups, or R q2 and R r2 together with the nitrogen to which they are attached form a 5, 6 or 7-membered heterocycle, wherein the 5, 6 or 7-membered heterocycle is optionally substituted with 1, 2, 3, 4 or 5 Z 1c or Z 1d groups;

each R n3 is independently selected from H, (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 3 -C 7 )carbocycle, heterocycle, heteroaryl, (C 6 -C 20 )aryl, (C 6 -C 20 )haloaryl, haloheteroaryl, haloheterocycle, (C 1 -C 8 )haloalkyl and (C 1 -C 8 )heteroalkyl;

each R p3 is independently selected from (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 3 -C 7 )carbocycle, heterocycle, heteroaryl, (C 6 -C 20 )aryl, (C 6 -C 20 )haloaryl, haloheteroaryl, haloheterocycle, (C 1 -C 8 )haloalkyl and (C 1 -C 8 )heteroalkyl;

R q3 and R r3 are each independently selected from H, (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 3 -C 7 )carbocycle, heterocycle, heteroaryl, (C 6 -C 20 )aryl, haloaryl, haloheteroaryl, haloheterocycle, (C 1 -C 8 )haloalkyl and (C 1 -C 8 )heteroalkyl, or R q3 and R r3 together with the nitrogen to which they are attached form a 5, 6 or 7-membered heterocycle;

each Z 2 is independently selected from (C 1 -C 6 )alkyl, (C 1 -C 6 )haloalkyl, (C 3 -C 7 )carbocycle, halogen, CN, OH and —O(C 1 -C 6 )alkyl;

each Z 3 is independently selected from (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 3 -C 7 )carbocycle, (C 6 -C 20 )aryl, halogen, —CN, —OR n4 , —S(O)R p4 , —NR n4 CO 2 R p4 , —NR n4 S(O) 2 R p4 , —C(O)R n4 , —C(O)OR n4 , —C(O)NR q4 R r4 and —B(OR q4 )(OR r4 ) wherein any (C 3 -C 7 )carbocycle and (C 6 -C 20 )aryl of Z 3 is optionally substituted with 1, 2, 3, 4, or 5 Z 3a or Z 3b groups, and wherein any (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl and (C 2 -C 8 )alkynyl of Z 3 is optionally substituted with 1, 2, 3, 4, or 5 Z 3a groups;

each Z 3a is independently selected from (C 3 -C 7 )carbocycle, (C 6 -C 20 )aryl, heteroaryl, heterocycle, halogen, —CN, —OR n5 , —OC(O)R p5 , —OC(O)NR q5 R r5 , —SR n5 , —S(O)R p5 , —S(O) 2 OH, —S(O) 2 R p5 , —S(O) 2 NR q5 R r5 , —NR q5 R r5 , —NR n5 COR p5 , —NR n5 CO 2 R p5 , —NR n5 CONR q5 R r5 , —NR n5 S(O) 2 R p5 , —NR n5 S(O) 2 OR p5 , —NR n5 S(O) 2 NR q5 R r5 , NO 2 , —C(O)R n5 , —C(O)OR n5 , and —C(O)NR q5 R r5 , wherein any (C 3 -C 7 )carbocycle, (C 6 -C 20 )aryl, heteroaryl and heterocycle of Z 1a is optionally substituted with 1, 2, 3, 4, or 5 Z 3c or Z 3d groups;

each Z 3b is independently selected from (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl and (C 2 -C 8 )alkynyl, wherein any (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl and (C 2 -C 8 )alkynyl of Z 3b is optionally substituted with 1, 2, 3, 4, or 5 Z 3c groups;

each Z 3c is independently selected from (C 3 -C 7 )carbocycle, (C 6 -C 20 )aryl, heteroaryl, heterocycle, halogen, —CN, —OR n6 , —OC(O)R p6 , —OC(O)NR q6 R r6 , —SR n6 , —S(O)R p6 , —S(O) 2 OH, —S(O) 2 R p6 , —S(O) 2 NR q6 R n5 , —NR q6 R r6 , —NR n6 COR p6 , —NR n6 CO 2 R p6 , —NR n6 CONR q6 R r6 , —NR n6 S(O) 2 R p6 , —NR n6 S(O) 2 OR p6 , —NR n6 S(O) 2 NR q6 R r6 , NO 2 , —C(O)R n6 , —C(O)OR n6 , —C(O)NR q6 R r6 , (C 6 -C 20 )haloaryl, haloheteroaryl, haloheterocycle and (C 1 -C 8 )heteroalkyl;

each Z 3d is independently selected from (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, and (C 1 -C 8 )haloalkyl;

each R n4 is independently selected from H, (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 3 -C 7 )carbocycle, heterocycle, heteroaryl and (C 6 -C 20 )aryl, wherein any (C 3 -C 7 )carbocycle, (C 6 -C 20 )aryl, heteroaryl and heterocycle of R n4 is optionally substituted with 1, 2, 3, 4, or 5 Z 3a or Z 3b groups, and wherein any (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl and (C 2 -C 8 )alkynyl of R n4 is optionally substituted with 1, 2, 3, 4, or 5 Z 3a groups;

each R p4 is independently selected from (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 3 -C 7 )carbocycle, heterocycle, heteroaryl and (C 6 -C 20 )aryl, wherein any (C 3 -C 7 )carbocycle, (C 6 -C 20 )aryl, heteroaryl, or heterocycle of R p4 is optionally substituted with 1, 2, 3, 4, or 5 Z 3a or Z 3b groups, and wherein any (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl or (C 2 -C 8 )alkynyl of R p4 is optionally substituted with 1, 2, 3, 4, or 5 Z 3a groups;

R q4 and R r4 are each independently selected from H, (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 3 -C 7 )carbocycle, heterocycle, heteroaryl and (C 6 -C 20 )aryl, wherein any (C 3 -C 7 )carbocycle, (C 6 -C 20 )aryl, heteroaryl and heterocycle of R q4 or R r4 is optionally substituted with one or more Z 3a or Z 3b groups, and wherein any (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl and (C 2 -C 8 )alkynyl of R q4 or R r4 is optionally substituted with 1, 2, 3, 4, or 5 Z 1a groups, or R q4 and R r4 together with the nitrogen to which they are attached form a 5, 6 or 7-membered heterocycle, wherein the 5, 6 or 7-membered heterocycle is optionally substituted with 1, 2, 3, 4, or 5 Z 3a or Z 3b groups;

each R n5 is independently selected from H, (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 3 -C 7 )carbocycle, heterocycle, heteroaryl and (C 6 -C 20 )aryl, wherein any (C 3 -C 7 )carbocycle, (C 6 -C 20 )aryl, heteroaryl and heterocycle of R n5 is optionally substituted with 1, 2, 3, 4, or 5 Z 3c or Z 3d groups, and wherein any (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl and (C 2 -C 8 )alkynyl of R n5 is optionally substituted with 1, 2, 3, 4, or 5 Z 3a groups;

each R p5 is independently selected from (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 3 -C 7 )carbocycle, heterocycle, heteroaryl and (C 6 -C 20 )aryl, wherein any (C 3 -C 7 )carbocycle, (C 6 -C 20 )aryl, heteroaryl and heterocycle of R p5 is optionally substituted with 1, 2, 3, 4, or 5 Z 3c or Z 3d groups, and wherein any (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl and (C 2 -C 8 )alkynyl of R p5 is optionally substituted with 1, 2, 3, 4, or 5 Z 3c groups;

R q5 and R r5 are each independently selected from H, (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 3 -C 7 )carbocycle, heterocycle, heteroaryl and (C 6 -C 20 )aryl, wherein any (C 3 -C 7 )carbocycle, (C 6 -C 20 )aryl, heteroaryl and heterocycle of R q5 or R r5 is optionally substituted with 1, 2, 3, 4, or 5 Z 3c or Z 3d groups, and wherein any (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl and (C 2 -C 8 )alkynyl of R q5 or R r5 is optionally substituted with 1, 2, 3, 4, or 5 Z 3c groups, or R q5 and R r5 together with the nitrogen to which they are attached form a 5, 6 or 7-membered heterocycle, wherein the 5, 6 or 7-membered heterocycle is optionally substituted with 1, 2, 3, 4, or 5 Z 3c or Z 3d groups;

each R n6 is independently selected from H, (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 3 -C 7 )carbocycle, heterocycle, heteroaryl, (C 6 -C 20 )aryl, (C 6 -C 20 )haloaryl, haloheteroaryl, haloheterocycle, (C 1 -C 8 )haloalkyl and (C 1 -C 8 )heteroalkyl;

each R p6 is independently selected from (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 3 -C 7 )carbocycle, heterocycle, heteroaryl, (C 6 -C 20 )aryl, (C 6 -C 20 )haloaryl, haloheteroaryl, haloheterocycle, (C 1 -C 8 )haloalkyl and (C 1 -C 8 )heteroalkyl;

R q6 and R r6 are each independently selected from H, (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 3 -C 7 )carbocycle, heterocycle, heteroaryl, (C 6 -C 20 )aryl, (C 6 -C 20 )haloaryl, haloheteroaryl, haloheterocycle, (C 1 -C 8 )haloalkyl and (C 1 -C 8 )heteroalkyl, or R q6 and R r6 together with the nitrogen to which they are attached form a 5, 6 or 7-membered heterocycle;

each Z 4 is independently selected from (C 3 -C 7 )carbocycle, halogen, methyl and —CN;

each Z 4c is independently selected from of (C 3 -C 7 )carbocycle, (C 6 -C 20 )aryl, heteroaryl, heterocycle, halogen, —CN, —OR n9 , —OC(O)R p9 , —OC(O)NR q9 R r9 , —SR n9 , —S(O)R p9 , —S(O) 2 OH, —S(O) 2 R p9 , —S(O) 2 NR q9 R r9 , —NR q9 R r9 , —NR n9 COR p9 , —NR n9 CO 2 R p9 , —NR n9 CONR q9 R r9 , —NR n9 S(O) 2 R p9 , —NR n9 S(O) 2 OR p9 , —NR n9 S(O) 2 NR q9 R r9 , NO 2 , —C(O)R n9 , —C(O)OR n9 , —C(O)NR q9 R r9 , (C 6 -C 20 )haloaryl, haloheteroaryl, haloheterocycle and (C 1 -C 8 )heteroalkyl;

each Z 4d is independently selected from of (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl and (C 1 -C 8 )haloalkyl;

each R n9 is independently selected from H, (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 3 -C 7 )carbocycle, heterocycle, heteroaryl, (C 6 -C 20 )aryl, (C 6 -C 20 )haloaryl, haloheteroaryl, haloheterocycle, (C 1 -C 8 )haloalkyl and (C 1 -C 8 )heteroalkyl;

each R p9 is independently selected from (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 3 -C 7 )carbocycle, heterocycle, heteroaryl, (C 6 -C 20 )aryl, (C 6 -C 20 )haloaryl, haloheteroaryl, haloheterocycle, (C 1 -C 8 )haloalkyl and (C 1 -C 8 )heteroalkyl; and

R q9 and R r9 are each independently selected from H, (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 3 -C 7 )carbocycle, heterocycle, heteroaryl, (C 6 -C 20 )aryl, (C 6 -C 20 )haloaryl, haloheteroaryl, haloheterocycle, (C 1 -C 8 )haloalkyl and (C 1 -C 8 )heteroalkyl; or R q9 and R r9 together with the nitrogen to which they are attached form a 5, 6 or 7-membered heterocycle.

2. The method of claim 1 , wherein the compound of formula I is a compound of formula Icc:

or a pharmaceutically acceptable salt thereof.

3. The method of claim 1 , wherein each R 3a and R 3b is H.

4. The method of claim 1 , wherein A is selected from:

wherein each Z 2a is independently selected from H and Z 2 .

5. The method of claim 1 , wherein Z 1 is selected from (C 6 -C 20 )aryl, heteroaryl and heterocycle, wherein any (C 6 -C 20 )aryl, heteroaryl, or heterocycle of Z 1 is optionally substituted with 1, 2, 3, 4, or 5 Z 1a or Z 1b groups.

6. The method of claim 1 , wherein each Z 1a is independently selected from (C 6 -C 20 )aryl, heteroaryl, heterocycle, (C 3 -C 7 )carbocycle, halogen, —CN, —OR n2 , —S(O) 2 R p2 , —S(O) 2 NR q2 R r2 , —NR q2 R r2 , —NR n2 COR p2 , —NR n2 CO 2 R p2 , —NR n2 CONR q2 R r2 , —NR n2 S(O) 2 R p2 , —C(O)R n2 and —C(O)NR q2 R r2 , wherein any (C 6 -C 20 )aryl, heteroaryl, heterocycle and (C 3 -C 7 )carbocycle of Z 1a is optionally substituted with 1, 2, 3, 4, or 5 Z 1c or Z 1d groups; and each Z 1b is independently selected from (C 1 -C 8 )alkyl and (C 2 -C 8 )alkynyl, wherein any (C 1 -C 8 )alkyl and (C 2 -C 8 )alkynyl of Z 1b is optionally substituted with 1, 2, 3, 4, or 5 Z 1c groups.

7. The method of claim 1 , wherein R 2 is a 6-membered aryl wherein the 6-membered aryl is optionally substituted with 1, 2, or 3 Z 4 groups.

8. The method of claim 1 , wherein R 2 is selected from:

9. The method of claim 1 , wherein R 1 is bicyclic-heteroaryl, tricyclic-heteroaryl, bicyclic-heterocycle or tricyclic-heterocycle, wherein any bicyclic-heteroaryl, tricyclic-heteroaryl, bicyclic-heterocycle or tricyclic-heterocycle of R 1 contains at least one partially unsaturated ring, and wherein any bicyclic-heteroaryl, tricyclic-heteroaryl, bicyclic-heterocycle or tricyclic-heterocycle of R 1 is optionally substituted with 1, 2, 3, 4, or 5 Z 3 groups.

10. The method of claim 1 , wherein each Z 3 is independently selected from methyl, trifluoromethyl, hydroxy, methoxy, benzyloxy, fluoro, —NHSO 2 CH 3 , 2-hydroxyprop-2yl, difluromethyl and amino.

11. The method of claim 1 , wherein the compound of formula I is selected from:

or a pharmaceutically acceptable salt thereof.

12. The method of claim 1 , comprising administering to the human in need thereof a therapeutically effective amount of a compound of formula I, or a pharmaceutically acceptable salt thereof, in combination with a therapeutically effective amount of one or more additional therapeutic agents selected from the group consisting HIV protease inhibiting compounds, HIV non-nucleoside inhibitors of reverse transcriptase, HIV nucleoside inhibitors of reverse transcriptase, HIV nucleotide inhibitors of reverse transcriptase, HIV integrase inhibitors, gp41 inhibitors, CXCR4 inhibitors, gp120 inhibitors, CCR5 inhibitors, capsid polymerization inhibitors, and other drugs for treating HIV, and combinations thereof.