Benzo[b]thiophene compounds as sting agonists
Compounds of general formula (Ia), compounds of general formula (Ia′), compounds of general formula (Ib), compounds of general formula (Ib′), compounds of general formula (I), compounds of general formula (I′), and their pharmaceutically acceptable salts, wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 8 , R 9 , X 1 , X 2 , and X 3 are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds of the disclosure.
1. A compound selected from the group consisting of:
or a pharmaceutically acceptable salt thereof.
2. The compound according to claim 1 , wherein the compound is selected from the group consisting of:
or a pharmaceutically acceptable salt thereof.
3. A pharmaceutical composition comprising a compound, or a pharmaceutically acceptable salt thereof, according to claim 1 , and a pharmaceutically acceptable carrier.
4. A compound selected from the group consisting of
and pharmaceutically acceptable salts thereof.
5. A pharmaceutical composition comprising the compound, or a pharmaceutically acceptable salt thereof, according to claim 4 , and a pharmaceutically acceptable carrier.
6. A compound selected from the group consisting of
7. A pharmaceutical composition comprising the compound, or a pharmaceutically acceptable salt thereof, according to claim 6 , and a pharmaceutically acceptable carrier.
8. A compound selected from the group consisting of
and pharmaceutically acceptable salts thereof.
9. A pharmaceutical composition comprising the compound, or a pharmaceutically acceptable salt thereof, according to claim 8 , and a pharmaceutically acceptable carrier.
10. A compound selected from the group consisting of
11. A pharmaceutical composition comprising the compound, or a pharmaceutically acceptable salt thereof, according to claim 10 , and a pharmaceutically acceptable carrier.
12. A compound selected from the group consisting of
and pharmaceutically acceptable salts thereof.
13. A pharmaceutical composition comprising the compound, or a pharmaceutically acceptable salt thereof, according to claim 12 , and a pharmaceutically acceptable carrier.
14. A compound selected from the group consisting of
15. A pharmaceutical composition comprising the compound, or a pharmaceutically acceptable salt thereof, according to claim 14 , and a pharmaceutically acceptable carrier.
16. A compound selected from the group consisting of
and pharmaceutically acceptable salts thereof.
17. A pharmaceutical composition comprising the compound, or a pharmaceutically acceptable salt thereof, according to claim 16 , and a pharmaceutically acceptable carrier.
18. A compound selected from the group consisting of
19. A pharmaceutical composition comprising the compound, or a pharmaceutically acceptable salt thereof, according to claim 18 , and a pharmaceutically acceptable carrier.
20. A compound selected from the group consisting of
and pharmaceutically acceptable salts thereof.
21. A pharmaceutical composition comprising the compound, or a pharmaceutically acceptable salt thereof, according to claim 20 , and a pharmaceutically acceptable carrier.
22. A compound selected from the group consisting of
23. A pharmaceutical composition comprising the compound, or a pharmaceutically acceptable salt thereof, according to claim 22 , and a pharmaceutically acceptable carrier.
24. A compound selected from the group consisting of
and pharmaceutically acceptable salts thereof.
25. A pharmaceutical composition comprising the compound, or a pharmaceutically acceptable salt thereof, according to claim 24 , and a pharmaceutically acceptable carrier.
26. A compound selected from the group consisting of
27. A pharmaceutical composition comprising the compound, or a pharmaceutically acceptable salt thereof, according to claim 26 , and a pharmaceutically acceptable carrier.