Anti-PD-1 antibody and use thereof
A PD-1 antibody or a functional fragment thereof, and use of said antibody in the preparation of a medicament for treating tumors are provided.
1. An antibody comprising a heavy chain and a light chain, which is capable of specifically binding to PD-1, wherein
the heavy chain comprises a heavy chain variable region which has the amino sequence represented by SEQ ID NO: 1, and the light chain comprises a light chain variable region which has the amino sequence represented by SEQ ID NO: 3; or
the heavy chain comprises a heavy chain variable region which has the amino sequence represented by SEQ ID NO: 4, and the light chain comprises a light chain variable region which has the amino sequence represented by SEQ ID NO: 6.
2. The antibody according to claim 1 , wherein
the heavy chain comprises a heavy chain variable region which has the amino sequence represented by SEQ ID NO: 4, and the light chain comprises a light chain variable region which has the amino sequence represented by SEQ ID NO: 6; and
wherein the antibody further comprises a human IgG4 or IgG1 heavy chain constant region and a human κ light chain constant region.
3. A pharmaceutical composition, which comprises the antibody according to claim 1 , and a pharmaceutically acceptable carrier.
4. A pharmaceutical composition, which comprises the antibody according to claim 2 , and a pharmaceutically acceptable carrier.