Medical nonwoven fabric, and preparation method thereof
The present invention relates to a medical nonwoven fabric comprising gelable cellulose derivative short-cut fibers as prepared by the paper making process, a preparation method thereof, and an adhesion prevention barrier using the same. The present invention provides a single phase of medical nonwoven fabric comprising gelable cellulose derivative short-cut fibers, to induce capillary action of micropores formed between the fibers and thereby control the gelation time, and provides a composite nonwoven fabric formed by laminating a nonwoven fabric layer comprising a different kind of biodegradable polymer material not susceptible to gelation on the single-phase of medical nonwoven fabric comprising gelable cellulose derivative short-cut fibers, thereby improving dimensional stability and convenience of surgical procedure. The present invention further provides a dyed medical nonwoven fabric to improve visibility, allowing easiness of recognizing the placement or location of the medical nonwoven fabric.
1. A method for preparing a medical nonwoven fabric, comprising:
mixing and dispersing a mixture of short-cut cellulose fibers, a binder material, and a biocompatible dispersing agent in an aqueous medium under agitation, wherein the mixture comprises with respect to 100 parts by weight of the cellulose fibers, 0 to 50 parts by weight of the binder material and 0 to 10 parts by weight of the biocompatible dispersing agent;
removing the aqueous medium by filtration and compressing the mixture to obtain a wet-laid nonwoven fabric of short-cut fibers;
calendering the wet-laid nonwoven fabric; and
subjecting the wet-laid nonwoven fabric to chemical treatment to form a wet-laid nonwoven fabric comprising gelable cellulose derivative short-cut fibers and having a pore size of 1 μm to 100 μm.
2. The method as claimed in claim 1 , wherein the binder material is a polymer with a hydroxyl group selected from the group consisting of polyvinyl alcohol and chitosan; or any one polymer which is a homopolymer or copolymer prepared from a compound selected from the group consisting of glycolide, lactide, caprolactone, dioxanone, and trimethylene carbonate.
3. The method as claimed in claim 2 , wherein the binder material is provided in the form of powder or fibers.
4. The method as claimed in claim 1 , wherein the biocompatible dispersing agent is any one selected from the group consisting of a poly(ethylene oxide)-(propylene oxide)-based nonionic surfactant, a Tween-series polysorbate surfactant, and polyacrylamide.
5. A method for preparing a medical composite nonwoven fabric, comprising:
manufacturing a first nonwoven fabric layer by performing the method of claim 1 ;
positioning a second nonwoven fabric layer comprising a biodegradable polymer material not susceptible to gelation on the first nonwoven fabric layer; and
bonding the first and second nonwoven fabric layers together by calendering to form the medical composite nonwoven fabric.
6. The method as claimed in claim 5 , further comprising:
conducting a dyeing process on the first nonwoven fabric layer with a solution containing a biocompatible dye or pigment.
7. The method as claimed in claim 5 , further comprising:
applying gamma radiation to the medical composite nonwoven fabric.
8. A method for preparing a medical composite nonwoven fabric, comprising:
manufacturing a first nonwoven fabric layer by performing the method of claim 1 ;
positioning a second nonwoven fabric layer comprising a biodegradable polymer material not susceptible to gelation on the first nonwoven fabric layer; and
partially bonding the first and second nonwoven fabric layers together by ultrasonic bonding to form the medical composite nonwoven fabric.
9. The method as claimed in claim 8 , further comprising:
conducting a dyeing process on the first nonwoven fabric layer with a solution containing a biocompatible dye or pigment.
10. The method as claimed in claim 8 , further comprising:
applying gamma radiation to the medical composite nonwoven fabric.