IP Library › Granted Patent US 10,464,962
Granted Patent B2
US 10,464,962 · App. 15/288,486 · Granted Nov 5, 2019

Oligosaccharide-protein conjugates

Inventors: Luis Z. Avila (Arlington, MA); Clark Q. Pan (Sudbury, MA); Patrick Finn (Weymouth, MA); John Harrahy (Medway, MA); Qun Zhou (Ashland, MA); Yunxiang Zhu (Wayland, MA); Paul A. Konowicz (Maynard, MA); Duncan E. Paterson (Zurich, CH); Andreas Peer (Basel, CH); Joseph P. Kutzko (Southborough, MA); Michael R. Reardon (North Attleboro, MA); James E. Stefano (Hopkinton, MA); Xiaoyang Zheng (Newton, MA); Robert J. Miller (E. Bridgewater, MA); Lauren Young (Hampton, NH)
Assignee: GENZYME CORPORATION
C07H15/04A61K47/61
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Quick Facts
Patent No.
US 10,464,962
App. No.
15/288,486
Granted
Nov 5, 2019
Kind
B2
Abstract

Provided herein are conjugates comprising a protein and an oligosaccharide of one of Formulae I-VI. Also provided herein are pharmaceutical compositions comprising such conjugates. Further provided herein are methods of treating a lysosomal storage disorder in a mammal by administration of an oligosaccharide-glycoprotein conjugate.

Claims (7)

1. A compound having the structure:

2. A compound having the structure:

wherein R 1 is a protecting group or a saccharide, wherein R 2 is hydrogen or methyl, and wherein R 3 is hydrogen or an allyl group.

3. The compound of claim 2 , wherein the compound is:

4. The compound of claim 2 , wherein the compound is:

5. The compound of claim 2 , wherein the compound is:

6. A compound selected from the group consisting of:

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 9, 2017
From: MILLER, ROBERT J; AVILA, LUIS Z; PAN, CLARK Q; FINN, PATRICK; HARRAHY, JOHN; ZHOU, QUN; ZHU, YUNXIANG; KONOWICZ, PAUL A; KUTZKO, JOSEPH P; REARDON, MICHAEL R; STEFANO, JAMES E; ZHENG, XIAOYANG; PATERSON, DUNCAN E; PEER, ANDREAS; YOUNG, LAUREN
To: GENZYME CORPORATION
Reel/Frame 042660/0583 →
Continuity (4)
Continuation 14445941 · Jul 29, 2014
Continuation 13140272
Provisional Application 61122851 · Dec 16, 2008
Related Publication 20180002365A1 · Jan 4, 2018
Cited By (7)
US 12,246,062 US 12,325,753 US 12,414,985 US 12,428,487 US 12,622,952 US 12,662,545 US 12,686,859