Simplified visualization and relevancy assessment of biological pathways
Embodiments are directed to computer implemented method of assessing a relevancy of a pathway to a disease of interest, the pathway having a source and a target. The method includes developing an impact of the source on the pathway. The method further includes developing a value of targeting, based at least in part on an alteration of the pathway, the pathway with a drug of interest. The method further includes identifying a relationship between the source and the target within the pathway. The method further includes combining: the impact of the source on the pathway; the value of targeting, based at least in part on the alteration of the pathway, the pathway with a drug of interest; and the relationship between the source and the target within the pathway, wherein the combining results in an assessment that represents the relevancy of the pathway to the disease of interest.
1. A computer implemented method configured to generate a simplified visualization of a relevancy of at least one biological pathway to a disease of interest, the at least one biological pathway having a source gene and a target druggable molecular entity, the method comprising performing multiple iterations of a simplified visualization and relevancy assessment method, wherein one iteration of the multiple iterations of the simplified visualization and relevancy assessment method comprises:
developing, by a processor and stored program instructions, an assessment of an impact of the source gene on the at least one biological pathway;
developing, by said processor and stored program instructions, a value of targeting the at least one biological pathway with a drug of interest, wherein the targeting is based at least in part on an alteration of the at least one biological pathway;
identifying, by said processor and stored program instructions, a relationship between the source gene and the target druggable molecular entity within the at least one biological pathway;
combining:
said assessment of said impact of the source gene on the at least one biological pathway;
said value of the targeting of the at least one biological pathway with a drug of interest; and
said relationship between the source gene and the target druggable molecular entity within the at least one biological pathway;
wherein said combining results in an assessment of the relevancy of the at least one biological pathway to the disease of interest;
ranking said assessment of the relevancy of the at least one biological pathway to the disease of interest in comparison with assessments of a relevancy of the at least one biological pathway to the disease of interest that result from others of the multiple iterations of the simplified visualization and relevancy assessment method; and
generating the simplified visualization of said at least one biological pathway, wherein the simplified visualization is implemented based at least in part on said ranking of said assessment of the relevancy of the at least one biological pathway to the disease of interest;
wherein generating the simplified visualization comprises:
creating a graph of said at least one biological pathway, wherein said graph comprises a plurality of nodes connected by edges;
identifying relevant paths of said graph;
removing from said relevant paths non-informative or non-significant nodes to create a first subgraph; and
simplifying relations and relative attributes of said first subgraph to create a second, simplified subgraph.
2. The computer implemented method of claim 1 , wherein said assessment of said impact of the source gene on the at least one biological pathway comprises a weighted value of the source gene.
3. The computer implemented method of claim 1 , wherein said value of the targeting of the at least one biological pathway comprises a weighted value of the target druggable molecular entity.
4. The computer implemented method of claim 1 , wherein said relationship between the source gene and the target druggable molecular entity within the at least one pathway comprises a topology of said at least one biological pathway from the source gene to the target druggable molecular entity.
5. The computer implemented method of claim 1 , wherein said relative attributes of said first graph are used to provide properties of said plurality of nodes or said plurality of edges of said second, simplified subgraph.