Platinum (II) complexes containing N-heterocyclic carbene ligand and pincer ligands, synthesis, and their applications in cancer treatment
Provided herein is a method of synthesis of Pt(II) complexes, a pharmaceutical composition comprises thereof. Also provided herein are the methods for the treatment and prevention of cancer/tumor in patients in need thereof by the administration of the Pt(II) complexes. Also provided is a method of detecting the Pt(II) complex in a biological system. Also provided is a method of making the Pt(II) complex The Pt(II) complexes possess anticancer activity such as the induction of cell death, inhibition of cellular proliferation, and inhibition of tumor growth in vivo.
1. A Pt(II) complex of formula I:
wherein R 1 is —CH 3 , —C 4 H 9 , -nC 6 H 13 , —CH 3 , or —CH 2 Ph, and
wherein R 2 is —CH 3 , —C 4 H 9 , -nC 6 H 13 , —C 8 H 17 , —C 16 H 33 , or —CH 2 Ph.
2. The Pt(II) complex of claim 1 wherein the Pt(II) complex has anti-tumor or anti-angiogenic properties.
3. A composition comprising the Pt(II) complex of claim 1 .
4. The composition of claim 3 wherein the Pt(II) complex comprises anti-tumor and/or anti-angiogenic properties.