Percutaneous absorption composition
The embodiments provide a percutaneous absorption composition for a basic medicament having improved transdermal absorbability. The percutaneous absorption composition comprises a sorbic acid and/or a metal sorbate as a percutaneous absorption promotor. The molar ration of the sorbic acid and/or the metal sorbate to the basic medicament is 0.5-2.5. The composition of the present disclosure may further comprise a basic component.
1. A percutaneous absorption non-aqueous composition comprising a basic medicament or a salt thereof and a sorbate component, wherein the molar ratio of the sorbate component to the basic medicament or a salt thereof is 0.5-2.5, and the sorbate component comprises a metal sorbate selected from the group consisting of sodium sorbate, potassium sorbate, and calcium sorbate.
2. The percutaneous absorption composition according to claim 1 , further comprising a basic component.
3. The percutaneous absorption composition according to claim 2 , wherein the basic component comprises one or more of an organic basic component, an inorganic basic component, and a salt of a strong base.
4. The percutaneous absorption composition according to claim 3 , wherein the organic basic compound is a C 2-9 alkanolamine.
5. The percutaneous absorption composition according to claim 3 , wherein the inorganic basic compound is a compound containing an alkali metal or an alkali earth metal.
6. The percutaneous absorption composition according to claim 2 , wherein the molar ratio of the basic component to the sorbate component is 0.4-3.0.
7. The percutaneous absorption composition according to claim 1 further comprising oleic acid.
8. The percutaneous absorption composition according to claim 1 further comprising a monovalent alcohol, a divalent alcohol, and a trivalent alcohol.
9. The percutaneous absorption composition according to claim 1 further comprising oleyl alcohol, glycerin, and propylene glycol and/or butylene glycol.
10. A method for increase percutaneous absorption of a basic medicament or a salt thereof comprising adding a metal sorbate to a non-aqueous composition comprising the basic medicament or a salt thereof to form the percutaneous absorption non-aqueous composition of claim 1 , wherein the metal sorbate is selected from the group consisting of sodium sorbate, potassium sorbate, and calcium sorbate.
11. The method according to claim 10 , wherein the molar ratio of the metal sorbate to the basic medicament or a salt thereof is 0.5-2.5.
12. The method according to claim 10 further comprising adding a basic component to the non-aqueous composition.
13. The method according to claim 10 , the molar ratio of the basic component to the metal sorbate is 0.4-3.0.
14. The method according to claim 10 , wherein the basic component comprises at least one of an organic basic component, an inorganic basic component, and a salt of a strong base.