IP Library › Granted Patent US 10,633,404
Granted Patent B2
US 10,633,404 · App. 15/557,453 · Granted Apr 28, 2020

Metal tricarbonyl complexes comprising substituted iminodiactic acid ligands and uses as radioisotope tracers

Inventors: Jeffrey Klenc (Atlanta, GA); Malgorzata Lipowska (Atlanta, GA); Andrew Taylor (Atlanta, GA)
Assignee: Emory University
C07F13/00A61B6/4057A61K51/0402A61K51/0478C07B59/004G01N33/5088G01N33/60G01N2800/347
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Quick Facts
Patent No.
US 10,633,404
App. No.
15/557,453
Granted
Apr 28, 2020
Kind
B2
Abstract

This disclosure relates to compositions comprising substituted iminodiacetic acid ligands and metal tricarbonyl complexes containing the ligands and derivatives thereof. In certain embodiments, the metal tricarbonyl complexes are used as radioisotope tracers such as renal tracers. In certain embodiments, the metal complexes comprise 99m Tc or Re. In certain embodiments, the ligands are substituted with a fluorine, a fluorine-18 (F 18 ) radioisotope, or other radionuclide.

Claims (5)

1. A metal tricarbonyl complex comprising a N-(2-fluoroethyl) iminodiacetate ligand or 18 F analog thereof and a metal tricarbonyl.

2. The metal tricarbonyl complex of claim 1 having the formula Re(CO) 3 (N-(2- 18 fluoroethyl)iminodiacetate).

3. The metal tricarbonyl complex of claim 1 having the formula 99m Tc(CO) 3 (N-(2-fluoroethyl)iminodiacetate).

4. A composition comprising a mixture of Re(CO) 3 (N-(2- 18 fluoroethyl)iminodiacetate) and 99m Tc(CO) 3 (N-(2-fluoroethyl)iminodiacetate).

5. A metal tricarbonyl complex Re(CO) 3 (N-(2-((tosyl)oxy)ethyl)iminodiacetate.

Continuity (2)
Provisional Application 62130953 · Mar 10, 2015
Related Publication 20180057517A1 · Mar 1, 2018