Drug delivery systems and methods
Drug delivery systems and methods are disclosed herein. In some embodiments, a drug delivery system can be configured to deliver a drug to a patient in coordination with a physiological parameter of the patient (e.g., the patient's natural cerebrospinal fluid (CSF) pulsation or the patient's heart or respiration rate). In some embodiments, a drug delivery system can be configured to use a combination of infusion and aspiration to control delivery of a drug to a patient. Catheters, controllers, and other components for use in the above systems are also disclosed, as are various methods of using such systems.
1. A drug delivery device, comprising:
an elongate body having a fluid lumen formed therein; and
a fluid port formed in the drug delivery device, the fluid port being defined by a helical slit formed in a wall of the drug delivery device;
wherein the helical slit extends from an interior surface of the wall to an exterior surface of the wall of the delivery device to thereby radially deliver fluid to an exterior of the drug delivery device.
2. The drug delivery device of claim 1 , wherein the helical slit extends from an interior surface of the body to an exterior surface of the body.
3. The drug delivery device of claim 1 , wherein the helical slit acts as a fluid communication path between an interior of the fluid lumen and an exterior of the drug delivery device.
4. The drug delivery device of claim 1 , wherein the helical slit is formed through an exterior wall of the drug delivery device.
5. The drug delivery device of claim 1 , wherein the helical slit is formed in a sidewall of a reduced-diameter portion of the drug delivery device.
6. The drug delivery device of claim 1 , wherein the helical slit is formed in a sidewall of an inner tube that extends within and projects forwardly from a distal end of the body.
7. The drug delivery device of claim 1 , further comprising an atraumatic distal tip defined by a substantially spherical bulb.
8. The drug delivery device of claim 1 , further comprising a second, distal-facing fluid port.
9. The drug delivery device of claim 1 , further comprising a tapered transition between a larger diameter proximal portion of the drug delivery device and a reduced diameter distal portion of the drug delivery device.
10. The drug delivery device of claim 9 , wherein the tapered transition is at least one of conical, convex, and concave.
11. The drug delivery device of claim 1 , wherein the drug delivery device comprises a catheter.
12. The drug delivery device of claim 1 , wherein the drug delivery device comprises a needle.
13. The drug delivery device of claim 1 , further comprising an inflatable member disposed at a distal end of the drug delivery device.
14. The drug delivery device of claim 13 , wherein the inflatable member is deployable from within a sharpened distal tip of the drug delivery device.
15. The drug delivery device of claim 13 , wherein the inflatable member includes a fluid port therein.
16. The drug delivery device of claim 15 , wherein the fluid port of the inflatable member comprises the helical slit.
17. A drug delivery device, comprising:
an elongate body having a fluid lumen therein and a fluid port through which fluid can move between an interior of the fluid lumen and a location exterior to the drug delivery device;
wherein at least a portion of the fluid lumen is helically-shaped, the helically-shaped portion of the fluid lumen being adjacent to the fluid port and configured to facilitate turbulent flow of fluid through the fluid port.
18. The drug delivery device of claim 17 , wherein the helically-shaped portion of the fluid lumen comprises a tubular passage that defines a plurality of looped coils.
19. A drug delivery device, comprising:
a needle having a sharpened distal tip; and
an inflatable member selectively deployable from a distal end of the sharpened tip, the inflatable member having a fluid port formed therein;
wherein the fluid port comprises a helical slit.