Compositions comprising omega-3 fatty acids, 17-HDHA and 18-HEPE and methods of using same

1. A composition comprising:

omega-3 fatty acids present in an amount of about 20% to about 95%, by weight, of the composition; and

17-hydroxy-4Z,7Z,10Z,13Z,15E,19Z-docosahexaenoic acid (“17-HDHA”), 14-hydroxy-4Z,7Z,10Z,12E,16Z,19Z-docosahexaenoic acid (“14-HDHA”), and 18-hydroxy-5Z,8Z,11Z,14Z,16E-eicosapentaenoic acid (“18-HEPE”), wherein the 18-HEPE is present in an amount of 0.02% to about 1%, by weight, of the composition.

2. The composition of claim 1 , wherein the composition is present in a capsule.

3. The composition of claim 1 , wherein the omega-3 fatty acids comprise docosahexaenoic acid (“DHA”) and/or eicosapentaenoic acid (“EPA”).

4. The composition of claim 1 , wherein the omega-3 fatty acids, 17-HDHA, and/or 18-HEPE are in the form of free fatty acids, esters, phospholipids, mono-glycerides, di-glycerides, tri-glycerides, or combinations thereof.

5. The composition of claim 1 , wherein the 17-HDHA is present in an amount of about 0.0002% to about 1%, by weight, of the composition.

6. The composition of claim 1 , wherein the 18-HEPE is present in an amount of about 0.03%, by weight, of the composition.

7. The composition of claim 1 , wherein 14-HDHA is present in an amount of about 0.001% to about 0.1%, by weight, of the composition.

8. The composition of claim 7 , wherein the 14-HDHA is present in an amount of about 0.01%, by weight, of the composition.

9. A dietary supplement, nutraceutical product,

nutritional composition for infant formulae and/or prenatal formulae, pharmaceutical composition, vaccine coadjuvant, chemotherapeutic coadjuvant or medical food composition comprising the composition of claim 1 .

10. A method of treating inflammation comprising administering the composition of claim 1 to a subject having inflammation.

11. A composition comprising:

omega-3 fatty acids present in an amount of about 20% to about 95%, by weight, of the composition; and

17-HDHA, 18-HEPE, and 14-HDHA, wherein the 18-HEPE is present in an amount of 0.02% to about 1%, the 17-HDHA is present in an amount of about 0.0002% to about 1%, and the 14-HDHA is present in an amount of about 0.001% to about 0.1%, by weight, of the composition.

12. The composition of claim 11 , wherein the 17-HDHA is present in an amount of about 0.01%, by weight, of the composition.

13. The composition of claim 11 , wherein the 18-HEPE is present in an amount of about 0.03%, by weight, of the composition.

14. The composition of claim 11 , wherein the omega-3 fatty acids comprise DHA and/or EPA.

15. The composition of claim 11 , wherein the omega-3 fatty acids, 17-HDHA, and/or 18-HEPE are in the form of free fatty acids, esters, phospholipids, mono-glycerides, di-glycerides, tri-glycerides, or combinations thereof.

16. A method of treating inflammation comprising administering the composition of claim 11 to a subject having inflammation.

17. A composition comprising:

omega-3 fatty acids in an amount of about 20% to about 95%, by weight, of the composition; and

17-HDHA, 18-HEPE, and 14-HDHA, wherein the 17-HDHA and 14-HDHA are each present in an amount of about 0.01%, by weight, of the composition, and the 18-HEPE is present in an amount of about 0.03%, by weight, of the composition.

18. The composition of claim 17 , wherein the omega-3 fatty acids, 17-HDHA, and/or 18-HEPE are in the form of free fatty acids, esters, phospholipids, mono-glycerides, di-glycerides, tri-glycerides, or combinations thereof.

19. The composition of claim 17 , wherein the omega-3 fatty acids comprise DHA and/or EPA.

20. A method of treating inflammation comprising administering the composition of claim 17 to a subject having inflammation.