Haemostatic device
A bioresorbable haemostatic foam sponge for adhering to a wound. The sponge has a tissue-contacting surface divided into a plurality of closely-spaced tissue contacting elements. Also disclosed are methods for forming the haemostatic sponge and methods of using the sponge.
1. A bioresorbable haemostatic foam sponge for adhering to a wound, the sponge comprising a tissue-contacting surface configured to contact the wound, which surface is divided into a plurality of closely-spaced tissue contacting elements such that there are at least 10 tissue contacting elements per 100 mm 2 of tissue-contacting surface,
wherein the sponge is manufactured from collagen, starch, gelatin or hyaluronic acid, and
wherein the tissue-contacting elements are columnar, the cross-sectional area of each tissue-contacting element is consistent throughout the depth of the tissue-contacting element, and the cross-sectional area of each face of each tissue contacting element is 50 mm 2 or less.
2. The haemostatic sponge according to claim 1 wherein each tissue contacting element has a depth of at least 2 mm.
3. The haemostatic sponge according to claim 1 , wherein each tissue contacting element has a depth of 10 mm or less.
4. The haemostatic sponge according to claim 1 , wherein the depth of each tissue contacting element is 80% or less of the depth of the sponge.
5. The haemostatic sponge according to claim 1 , wherein the cross-sectional shape of each tissue contacting element is substantially rectangular.
6. The haemostatic sponge according to claim 1 , wherein each face of each tissue contacting element has a cross-sectional area of 25 mm 2 or less.
7. The haemostatic sponge according to claim 1 , wherein the maximum cross-sectional linear dimension of each tissue contacting element is 10 mm or less.
8. The haemostatic sponge according to claim 1 , wherein the maximum cross-sectional linear dimension is two times or less than the depth of the tissue contacting element.
9. The haemostatic sponge according to claim 1 , wherein the tissue contacting elements are arranged such that each tissue contacting element is within 1 mm of another tissue contacting element.
10. The haemostatic sponge according to claim 1 , wherein the sponge has pores with a diameter of 3 mm or less.
11. The haemostatic sponge according to claim 1 which comprises an immobilised haemostatic agent.
12. The haemostatic sponge according to claim 11 , wherein the haemostatic agent comprises a clotting factor.
13. The haemostatic sponge according to claim 11 , wherein the haemostatic agent further comprises carriers on which a plurality of fibrinogen-binding peptides is immobilised.
14. The haemostatic sponge according to claim 1 , comprising reactive chemical groups that can react to form covalent bonds when contacted with tissue.
15. The haemostatic sponge according to claim 1 in which the tissue contacting elements have been formed by cutting or incising a surface of a sponge.
16. The haemostatic sponge according to claim 1 , wherein the sponge is manufactured from gelatin.
17. The haemostatic sponge according to claim 1 , wherein the tissue contacting elements are arranged such that each tissue contacting element is within 0.1 mm of another tissue contacting element.
18. The haemostatic sponge according to claim 1 , wherein at least 50% of the pores have a diameter between 1 and 1500 μm.
19. A method for forming the haemostatic sponge according to claim 1 , comprising cutting or embossing a surface of a haemostatic sponge.
20. A method of controlling bleeding, comprising administering the haemostatic sponge according to claim 1 , to a wound.