IP Library Granted Patent US 10,669,296
Granted Patent B2
US 10,669,296 · App. 15/110,343 · Granted Jun 2, 2020

LXR agonists and uses thereof

Inventors: Eduardo J. Martinez (Bryn Mawr, PA); Bernd Kaiser (Wallingford, CT); Sohail F. Tavazoie (New York, NY); Isabel Kurth (New York, NY); Foster Casimir Gonsalves (Long Island City, NY); David M. Darst, Jr. (New York, NY); Masoud Fakhr Tavazoie (New York, NY)
Assignee: Rgenix, Inc.
C07F9/657172A61K31/138A61K31/145A61K31/165A61K31/195A61K31/24A61K31/357A61K31/366A61K31/397A61K31/40A61K31/445A61K31/661A61K31/675A61K45/06C07B59/004C07C217/18C07C217/20C07C217/22C07C217/58C07C259/06C07C311/51C07C317/04C07C317/14C07C317/22C07C317/46C07C323/09C07C323/32C07D205/04C07D207/48C07D209/48C07D211/42C07D211/96C07D311/76C07D317/46C07F9/09C07F9/094C07F9/12C07F9/304C07F9/65744C07B2200/05C07C2601/14
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Quick Facts
Patent No.
US 10,669,296
App. No.
15/110,343
Granted
Jun 2, 2020
Kind
B2
Abstract

This invention features compounds that modulate the activity of liver X receptors, pharmaceutical compositions including the compounds of the invention, and methods of utilizing those compositions for modulating the activity of liver X receptors in the treatment of cancer.

Claims (531)

1. A compound of Formula I:

wherein A is:

wherein e is 0, 1, 2, 3, or 4;

R A is optionally substituted C 1 -C 6 acyl, optionally substituted C 1 -C 6 alkyl, optionally substituted C 2 -C 6 alkenyl, optionally substituted C 2 -C 6 alkynyl, optionally substituted C 2 -C 6 heteroalkenyl, optionally substituted C 2 -C 6 heteroalkynyl, optionally substituted C 3 -C 10 cycloalkyl, optionally substituted C 4 -C 10 cycloalkenyl, optionally substituted C 8 -C 12 cycloalkynyl, optionally substituted C 6 -C 10 aryl, optionally substituted C 6 -C 10 aryl C 1 -C 6 alkyl, optionally substituted C 2 -C 9 heteroaryl, optionally substituted C 2 -C 9 heteroaryl C 1 -C 6 alkyl, optionally substituted C 2 -C 9 heterocyclyl, 8F optionally substituted C 2 -C 9 heterocyclyl C 1 -C 6 alkyl;

each R B is independently hydroxyl, optionally substituted amino, halo, thiol, optionally substituted amino acid, optionally substituted C 1 -C 6 acyl, optionally substituted C 1 -C 6 alkyl, optionally substituted C 2 -C 6 alkenyl, optionally substituted C 2 -C 6 alkynyl, optionally substituted C 1 -C 6 heteroalkyl, optionally substituted C 2 -C 6 heteroalkenyl, optionally substituted C 2 -C 6 heteroalkynyl, optionally substituted C 3 -C 10 cycloalkyl, optionally substituted C 8 -C 12 cycloalkenyl, optionally substituted C 4 -C 10 cycloalkynyl, optionally substituted C 6 -C 10 aryl, optionally substituted C 6 -C 10 aryl C 1 -C 6 alkyl, optionally substituted C 2 -C 9 heteroaryl, optionally substituted C 2 -C 9 heteroaryl C 1 -C 6 alkyl, optionally substituted C 2 -C 9 heterocyclyl, or optionally substituted C 2 -C 9 heterocyclyl C 1 -C 6 alkyl; and

L is —O—;

a is 2 or 3;

b is 1;

c is 0;

d is 1;

each R 1 , R 2 , R 6 , R 7 , R 8 , and R 9 are independently hydrogen or optionally substituted C 1 -C 6 alkyl;

R 3 is hydrogen, halo, or optionally substituted C 1 -C 6 alkyl;

R 4 is hydrogen, optionally substituted C 1 -C 6 alkyl, optionally substituted C 3 -C 10 cycloalkyl, or optionally substituted C 6 -C 10 aryl;

R 5 is optionally substituted C 6 -C 10 aryl; and

B is optionally substituted C 6 -C 10 aryl;

or a pharmaceutically acceptable salt thereof.

2. The compound of claim 1 , wherein each R 6 and R 7 is hydrogen.

3. The compound of claim 1 , wherein R 3 is hydrogen.

4. The compound of claim 1 , wherein R 4 is hydrogen, phenyl, cyclohexyl, or methyl.

5. The compound of claim 1 , wherein R 5 is phenyl.

6. The compound of claim 1 , wherein each R 8 and R 9 is hydrogen.

7. The compound of claim 1 , wherein —(CR 1 R 2 ) a — has the structure:

8. The compound of claim 7 , wherein —(CR 1 R 2 ) 3 — has the structure:

9. The compound of claim 1 , wherein said compound has the structure:

10. The compound of claim 1 , wherein said optionally substituted C 6 -C 10 aryl is 2-chloro-3-trifluoromethyl-phenyl, 2-fluoro-3-trifluoromethyl-phenyl, 3-(1,1,2,2-tetrafluoroethoxy)-phenyl, 3-trifluoromethyl-phenyl, 3-trifluoromethyl-4-fluoro-phenyl, or 3-trifluoromethoxy-phenyl.

11. The compound of claim 10 , wherein B is 2-chloro-3-trifluoromethyl-phenyl, 2-fluoro-3-trifluoromethyl-phenyl, or 3-trifluoromethyl-phenyl.

12. The compound of claim 11 , wherein B is 2-chloro-3-trifluoromethyl-phenyl.

13. A compound, or pharmaceutically acceptable salt thereof, selected from:

(2-fluoro-6-methanesulfonyl-4-{3-[(2-methyl-2-phenylpropyl)({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}phenyl)methanol,

(2-fluoro-6-methanesulfonyl-4-{3-[(2-phenylethyl)({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}phenyl) methanol,

(2-fluoro-6-methanesulfonyl-4-{3-[(2-phenylpropyl)({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}phenyl) methanol,

(4-{3-[benzyl({[2-fluoro-3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-fluoro-6-methanesulfonylphenyl) methanol,

(4-{3-[benzyl({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-fluoro-6-methanesulfonylphenyl) methanol,

[2-fluoro-4-(3-{[(4-fluorophenyl)methyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-6-methanesulfonylphenyl]methanol,

[2-fluoro-4-(3-{[2-(4-fluorophenyl)-2-methylpropyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-6-methanesulfonylphenyl]methanol,

[2-fluoro-4-(3-{[2-(4-fluorophenyl)ethyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-6-methanesulfonylphenyl]methanol,

[2-fluoro-4-(3-{[2-(4-fluorophenyl)propyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-6-methanesulfonylphenyl]methanol,

{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[2,2-difluoro-2-(4-fluorophenyl)ethyl]amino)propoxy]-2-fluoro-6-methanesulfonylphenyl}methanol,

[4-(3-{[2,2-difluoro-2-(4-fluorophenyl)ethyl]({[2-fluoro-3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-2-fluoro-6-methanesulfonylphenyl]methanol,

[4-(3-{[2,2-difluoro-2-(4-fluorophenyl)ethyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-2-fluoro-6-methanesulfonylphenyl]methanol,

{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[(4-fluorophenyl)methyl]amino)propoxy]-2-fluoro-6-methanesulfonylphenyl}methanol,

{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)-2-methylpropyl]amino)propoxy]-2-fluoro-6-methanesulfonylphenyl}methanol,

{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)ethyl]amino)propoxy]-2-fluoro-6-methanesulfonylphenyl}methanol,

{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)propyl]amino)propoxy]-2-fluoro-6-methanesulfonylphenyl}methanol,

{2-fluoro-4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}(2-methyl-2-phenylpropyl)amino)propoxy]-6-methanesulfonylphenyl}methanol,

{2-fluoro-4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}(2-phenylethyl)amino)propoxy]-6-methanesulfonylphenyl}methanol,

{2-fluoro-4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}(2-phenylpropyl)amino)propoxy]-6-methanesulfonylphenyl}methanol,

{2-fluoro-4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[(4-fluorophenyl)methyl]amino)propoxy]-6-methanesulfonylphenyl}methanol,

{2-fluoro-4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)-2-methylpropyl]amino)propoxy]-6-methanesulfonylphenyl}methanol,

{2-fluoro-4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)ethyl]amino)propoxy]-6-methanesulfonylphenyl}methanol,

{2-fluoro-4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)propyl]amino)propoxy]-6-methanesulfonylphenyl}methanol,

(2-methanesulfonyl-4-{3-[(2-methyl-2-phenylpropyl)({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}phenyl) methanol,

(2-methanesulfonyl-4-{3-[(2-phenylethyl)({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}phenyl)methanol,

(2-methanesulfonyl-4-{3-[(2-phenylpropyl)({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}phenyl)methanol,

{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2,2-diphenylethyl)amino)propoxy]-2-methanesulfonylphenyl}methanol,

(4-{3-[(2,2-diphenylethyl)({[2-fluoro-3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-methanesulfonylphenyl) methanol,

(4-{3-[(2,2-diphenylethyl)({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-methanesulfonylphenyl) methanol,

(4-{3-[benzyl({[2-chloro-3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-methanesulfonylphenyl) methanol,

(4-{3-[benzyl({[2-fluoro-3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-methanesulfonylphenyl) methanol,

(4-{3-[benzyl({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-methanesulfonylphenyl) methanol,

[4-(3-{[(4-fluorophenyl)methyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-2-methanesulfonylphenyl]methanol,

[4-(3-{[2-(4-fluorophenyl)-2-methylpropyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-2-methanesulfonylphenyl]methanol,

[4-(3-{[2-(4-fluorophenyl)ethyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-2-methanesulfonylphenyl]methanol,

[4-(3-{[2-(4-fluorophenyl)propyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-2-methanesulfonylphenyl]methanol,

{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[2,2-difluoro-2-(4-fluorophenyl)ethyl]amino)propoxy]-2-methanesulfonylphenyl}methanol,

[4-(3-{[2,2-difluoro-2-(4-fluorophenyl)ethyl]({[2-fluoro-3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-2-methanesulfonylphenyl]methanol,

[4-(3-{[2,2-difluoro-2-(4-fluorophenyl)ethyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-2-methanesulfonylphenyl]methanol,

{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2-methyl-2-phenylpropyl)amino)propoxy]-2-methanesulfonylphenyl}methanol,

{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2-phenylethyl)amino)propoxy]-2-methanesulfonylphenyl}methanol,

{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2-phenylpropyl)amino)propoxy]-2-methanesulfonylphenyl}methanol,

{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[(4-fluorophenyl)methyl]amino)propoxy]-2-methanesulfonylphenyl}methanol,

{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)-2-methylpropyl]amino)propoxy]-2-methanesulfonylphenyl}methanol,

{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)ethyl]amino)propoxy]-2-methanesulfonylphenyl}methanol,

{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)propyl]amino)propoxy]-2-methanesulfonylphenyl}methanol,

{4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}(2-methyl-2-phenylpropyl)amino)propoxy]-2-methanesulfonylphenyl}methanol,

{4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}(2-phenylethyl)amino)propoxy]-2-methanesulfonylphenyl}methanol,

{4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}(2-phenylpropyl)amino)propoxy]-2-methanesulfonylphenyl}methanol,

{4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[(4-fluorophenyl)methyl]amino)propoxy]-2-methanesulfonylphenyl}methanol,

{4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)-2-methylpropyl]amino)propoxy]-2-methanesulfonylphenyl}methanol,

{4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)ethyl]amino)propoxy]-2-methanesulfonylphenyl}methanol,

{4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl) propyl]amino)propoxy]-2-methanesulfonylphenyl}methanol,

[3-(3-methanesulfonylphenoxy)propyl](2-methyl-2-phenylpropyl){[3-(trifluoromethyl)phenyl]methyl}amine,

[3-(3-methanesulfonylphenoxy)propyl](2-phenylethyl){[3-(trifluoromethyl)phenyl]methyl}amine,

[3-(3-methanesulfonylphenoxy)propyl](2-phenylpropyl){[3-(trifluoromethyl)phenyl]methyl}amine,

(2,2-diphenylethyl)({[2-fluoro-3-(trifluoromethyl)phenyl]methyl})[3-(3-methanesulfonylphenoxy)propyl]amine,

(2,2-diphenylethyl)[3-(3-methanesulfonylphenoxy)propyl]{[3-(trifluoromethyl)phenyl]methyl}amine,

benzyl({[2-chloro-3-(trifluoromethyl)phenyl]methyl})[3-(3-methanesulfonylphenoxy)propyl]amine,

benzyl({[2-fluoro-3-(trifluoromethyl)phenyl]methyl})[3-(3-methanesulfonylphenoxy)propyl]amine,

benzyl[3-(3-methanesulfonylphenoxy)propyl]{[3-(trifluoromethyl)phenyl]methyl}amine,

[(4-fluorophenyl)methyl][3-(3-methanesulfonylphenoxy)propyl]{[3-(trifluoromethyl)phenyl]methyl}amine,

[2-(4-fluorophenyl)-2-methylpropyl][3-(3-methanesulfonylphenoxy)propyl]{[3-(trifluoromethyl)phenyl]methyl}amine,

[2-(4-fluorophenyl)ethyl][3-(3-methanesulfonylphenoxy)propyl]{[3-(trifluoromethyl)phenyl]methyl}amine,

[2-(4-fluorophenyl) propyl][3-(3-methanesulfonylphenoxy)propyl]{[3-(trifluoromethyl)phenyl]methyl}amine,

{[2-chloro-3-(trifluoromethyl)phenyl]methyl}[2,2-difluoro-2-(4-fluorophenyl)ethyl][3-(3-methanesulfonylphenoxy)propyl]amine,

[2,2-difluoro-2-(4-fluorophenyl) ethyl]({[2-fluoro-3-(trifluoromethyl)phenyl]methyl})[3-(3-methanesulfonylphenoxy)propyl]amine,

[2,2-difluoro-2-(4-fluorophenyl) ethyl][3-(3-methanesulfonylphenoxy)propyl]{[3-(trifluoromethyl)phenyl]methyl}amine,

{[2-chloro-3-(trifluoromethyl)phenyl]methyl}[3-(3-methanesulfonylphenoxy)propyl](2-methyl-2-phenylpropyl)amine,

{[2-chloro-3-(trifluoromethyl)phenyl]methyl}[3-(3-methanesulfonylphenoxy)propyl](2-phenylethyl)amine,

{[2-chloro-3-(trifluoromethyl)phenyl]methyl}[3-(3-methanesulfonylphenoxy)propyl](2-phenylpropyl)amine,

{[2-chloro-3-(trifluoromethyl)phenyl]methyl}[(4-fluorophenyl)methyl][3-(3-methanesulfonylphenoxy)propyl]amine,

{[2-chloro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)-2-methylpropyl][3-(3-methanesulfonylphenoxy)propyl]amine,

{[2-chloro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)ethyl][3-(3-methanesulfonylphenoxy)propyl]amine,

{[2-chloro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl) propyl][3-(3-methanesulfonylphenoxy)propyl]amine,

{[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[3-(3-methanesulfonylphenoxy)propyl](2-methyl-2-phenylpropyl)amine,

{[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[3-(3-methanesulfonylphenoxy)propyl](2-phenylethyl)amine,

{[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[3-(3-methanesulfonylphenoxy)propyl](2-phenylpropyl)amine,

{[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[(4-fluorophenyl)methyl][3-(3-methanesulfonylphenoxy)propyl]amine,

{[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)-2-methylpropyl][3-(3-methanesulfonylphenoxy)propyl]amine,

{[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)ethyl][3-(3-methanesulfonylphenoxy)propyl]amine,

{[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)propyl][3-(3-methanesulfonylphenoxy)propyl]amine,

1-(2-fluoro-6-methanesulfonyl-4-{3-[(2-phenylethyl)({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}phenyl)ethan-1-ol,

1-(2-fluoro-6-methanesulfonyl-4-{3-[(2-methyl-2-phenylpropyl)({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}phenyl)ethan-1-ol,

1-(2-fluoro-6-methanesulfonyl-4-{3-[(2-phenylpropyl) ({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}phenyl)ethan-1-ol,

1-(4-{3-[(2,2-diphenylethyl)({[2-fluoro-3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-fluoro-6-methanesulfonylphenyl)ethan-1-ol,

1-(4-{3-[(2,2-diphenylethyl)({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-fluoro-6-methanesulfonylphenyl)ethan-1-ol,

1-(4-{3-[benzyl({[2-chloro-3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-fluoro-6-methanesulfonylphenyl)ethan-1-ol,

1-(4-{3-[benzyl({[2-fluoro-3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-fluoro-6-methanesulfonylphenyl)ethan-1-ol,

1-(4-{3-[benzyl({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-fluoro-6-methanesulfonylphenyl)ethan-1-ol,

1-[2-fluoro-4-(3-{[(4-fluorophenyl)methyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-6-methanesulfonylphenyl]ethan-1-ol,

1-[2-fluoro-4-(3-{[2-(4-fluorophenyl)-2-methylpropyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-6-methanesulfonylphenyl]ethan-1-ol,

1-[2-fluoro-4-(3-{[2-(4-fluorophenyl)ethyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-6-methanesulfonylphenyl]ethan-1-ol,

1-[2-fluoro-4-(3-{[2-(4-fluorophenyl)propyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-6-methanesulfonylphenyl]ethan-1-ol,

1-{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[2,2-difluoro-2-(4-fluorophenyl)ethyl]amino)propoxy]-2-fluoro-6-methanesulfonylphenyl}ethan-1-ol,

1-[4-(3-{[2,2-difluoro-2-(4-fluorophenyl)ethyl]({[2-fluoro-3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-2-fluoro-6-methanesulfonylphenyl]ethan-1-ol,

1-[4-(3-{[2,2-difluoro-2-(4-fluorophenyl)ethyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-2-fluoro-6-methanesulfonylphenyl]ethan-1-ol,

1-{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2-methyl-2-phenylpropyl)amino)propoxy]-2-fluoro-6-methanesulfonylphenyl}ethan-1-ol,

1-{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2-phenylpropyl)amino)propoxy]-2-fluoro-6-methanesulfonylphenyl}ethan-1-ol,

1-{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)-2-methylpropyl]amino)propoxy]-2-fluoro-6-methanesulfonylphenyl}ethan-1-ol,

1-{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[(4-fluorophenyl)methyl]amino)propoxy]-2-fluoro-6-methanesulfonylphenyl}ethan-1-ol,

1-{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)ethyl]amino)propoxy]-2-fluoro-6-methanesulfonylphenyl}ethan-1-ol,

1-{2-fluoro-4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}(2-methyl-2-phenylpropyl)amino)propoxy]-6-methanesulfonylphenyl}ethan-1-ol,

1-{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)propyl]amino)propoxy]-2-fluoro-6-methanesulfonylphenyl}ethan-1-ol,

1-{2-fluoro-4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}(2-phenylethyl)amino)propoxy]-6-methanesulfonylphenyl}ethan-1-ol,

1-{2-fluoro-4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}(2-phenylpropyl)amino)propoxy]-6-methanesulfonylphenyl}ethan-1-ol,

1-{2-fluoro-4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[(4-fluorophenyl)methyl]amino)propoxy]-6-methanesulfonylphenyl}ethan-1-ol,

1-{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2-phenylethyl)amino)propoxy]-2-fluoro-6-methanesulfonylphenyl}ethan-1-ol,

1-{2-fluoro-4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)-2-methylpropyl]amino)propoxy]-6-methanesulfonylphenyl}ethan-1-ol,

1-{2-fluoro-4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)ethyl]amino)propoxy]-6-methanesulfonylphenyl}ethan-1-ol,

1-{2-fluoro-4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)propyl]amino)propoxy]-6-methanesulfonylphenyl}ethan-1-ol,

1-(2-methanesulfonyl-4-{3-[(2-methyl-2-phenylpropyl)({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}phenyl)ethan-1-ol,

1-(2-methanesulfonyl-4-{3-[(2-phenylethyl)({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}phenyl)ethan-1-ol,

1-(2-methanesulfonyl-4-{3-[(2-phenylpropyl)({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}phenyl)ethan-1-ol,

1-(4-{3-[(2,2-diphenylethyl)({[2-fluoro-3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-methanesulfonylphenyl)ethan-1-ol,

1-(4-{3-[(2,2-diphenylethyl)({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-methanesulfonylphenyl)ethan-1-ol,

1-(4-{3-[benzyl({[2-chloro-3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-methanesulfonylphenyl)ethan-1-ol,

1-(4-{3-[benzyl({[2-fluoro-3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-methanesulfonylphenyl)ethan-1-ol,

1-(4-{3-[benzyl({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-methanesulfonylphenyl)ethan-1-ol,

1-[4-(3-{[(4-fluorophenyl)methyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-2-methanesulfonylphenyl]ethan-1-ol,

1-[4-(3-{[2-(4-fluorophenyl)-2-methylpropyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-2-methanesulfonylphenyl]ethan-1-ol,

1-[4-(3-{[2-(4-fluorophenyl)ethyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-2-methanesulfonylphenyl]ethan-1-ol,

1-[4-(3-{[2-(4-fluorophenyl)propyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-2-methanesulfonylphenyl]ethan-1-ol,

1-{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[2,2-difluoro-2-(4-fluorophenyl)ethyl]amino)propoxy]-2-methanesulfonylphenyl}ethan-1-ol,

1-[4-(3-{[2,2-difluoro-2-(4-fluorophenyl)ethyl]({[2-fluoro-3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-2-methanesulfonylphenyl]ethan-1-ol,

1-[4-(3-{[2,2-difluoro-2-(4-fluorophenyl)ethyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-2-methanesulfonylphenyl]ethan-1-ol,

1-{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2-methyl-2-phenylpropyl)amino)propoxy]-2-methanesulfonylphenyl}ethan-1-ol,

1-{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2-phenylethyl)amino)propoxy]-2-methanesulfonylphenyl}ethan-1-ol,

1-{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2-phenylpropyl)amino)propoxy]-2-methanesulfonylphenyl}ethan-1-ol,

1-{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[(4-fluorophenyl)methyl]amino)propoxy]-2-methanesulfonylphenyl}ethan-1-ol,

1-{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)-2-methylpropyl]amino)propoxy]-2-methanesulfonylphenyl}ethan-1-ol,

1-{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)ethyl]amino)propoxy]-2-methanesulfonylphenyl}ethan-1-ol,

1-{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)propyl]amino)propoxy]-2-methanesulfonylphenyl}ethan-1-ol,

1-{4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}(2-methyl-2-phenylpropyl)amino)propoxy]-2-methanesulfonylphenyl}ethan-1-ol,

1-{4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}(2-phenylethyl)amino)propoxy]-2-methanesulfonylphenyl}ethan-1-ol,

1-{4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}(2-phenylpropyl)amino)propoxy]-2-methanesulfonylphenyl}ethan-1-ol,

1-{4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[(4-fluorophenyl)methyl]amino)propoxy]-2-methanesulfonylphenyl}ethan-1-ol,

1-{4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)-2-methylpropyl]amino)propoxy]-2-methanesulfonylphenyl}ethan-1-ol,

1-{4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)ethyl]amino)propoxy]-2-methanesulfonylphenyl}ethan-1-ol,

1-{4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)propyl]amino)propoxy]-2-methanesulfonylphenyl}ethan-1-ol,

1-{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2,2-diphenylethyl)amino)propoxy]-2-methanesulfonylphenyl}ethan-1-ol,

2-fluoro-6-methanesulfonyl-4-{3-[(2-phenylethyl)({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}benzaldehyde,

4-{3-[(2,2-diphenylethyl)({[2-fluoro-3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-fluoro-6-methanesulfonylbenzaldehyde,

2-fluoro-6-methanesulfonyl-4-{3-[(2-methyl-2-phenylpropyl)({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}benzaldehyde,

4-{3-[(2,2-diphenylethyl)({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-fluoro-6-methanesulfonylbenzaldehyde,

4-{3-[benzyl({[2-chloro-3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-fluoro-6-methanesulfonylbenzaldehyde,

4-{3-[benzyl({[2-fluoro-3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-fluoro-6-methanesulfonylbenzaldehyde,

4-{3-[benzyl({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-fluoro-6-methanesulfonylbenzaldehyde,

2-fluoro-4-(3-{[(4-fluorophenyl)methyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-6-methanesulfonylbenzaldehyde,

2-fluoro-4-(3-{[2-(4-fluorophenyl)-2-methylpropyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-6-methanesulfonylbenzaldehyde,

2-fluoro-4-(3-{[2-(4-fluorophenyl)ethyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-6-methanesulfonylbenzaldehyde,

2-fluoro-4-(3-{[2-(4-fluorophenyl)propyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-6-methanesulfonylbenzaldehyde,

4-(3-{[2,2-difluoro-2-(4-fluorophenyl)ethyl]({[2-fluoro-3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-2-fluoro-6-methanesulfonylbenzaldehyde,

4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[2,2-difluoro-2-(4-fluorophenyl)ethyl]amino)propoxy]-2-fluoro-6-methanesulfonylbenzaldehyde,

4-(3-{[2,2-difluoro-2-(4-fluorophenyl)ethyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-2-fluoro-6-methanesulfonylbenzaldehyde,

4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2-methyl-2-phenylpropyl)amino)propoxy]-2-fluoro-6-methanesulfonylbenzaldehyde,

4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2-phenylethyl)amino)propoxy]-2-fluoro-6-methanesulfonylbenzaldehyde,

4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2-phenylpropyl)amino)propoxy]-2-fluoro-6-methanesulfonylbenzaldehyde,

4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[(4-fluorophenyl)methyl]amino)propoxy]-2-fluoro-6-methanesulfonylbenzaldehyde,

4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)-2-methylpropyl]amino)propoxy]-2-fluoro-6-methanesulfonylbenzaldehyde,

2-fluoro-4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}(2-methyl-2-phenylpropyl)amino)propoxy]-6-methanesulfonylbenzaldehyde,

4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)propyl]amino)propoxy]-2-fluoro-6-methanesulfonylbenzaldehyde,

2-fluoro-4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}(2-phenylethyl)amino)propoxy]-6-methanesulfonylbenzaldehyde,

2-fluoro-4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}(2-phenylpropyl)amino)propoxy]-6-methanesulfonylbenzaldehyde,

2-fluoro-4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[(4-fluorophenyl)methyl]amino)propoxy]-6-methanesulfonylbenzaldehyde,

2-fluoro-4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)-2-methylpropyl]amino)propoxy]-6-methanesulfonylbenzaldehyde,

2-fluoro-6-methanesulfonyl-4-{3-[(2-phenylpropyl)({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}benzaldehyde,

2-fluoro-4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)ethyl]amino)propoxy]-6-methanesulfonylbenzaldehyde,

2-fluoro-4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)propyl]amino)propoxy]-6-methanesulfonylbenzaldehyde,

4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)ethyl]amino)propoxy]-2-fluoro-6-methanesulfonylbenzaldehyde,

2-methanesulfonyl-4-{3-[(2-methyl-2-phenylpropyl)({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}benzaldehyde,

2-methanesulfonyl-4-{3-[(2-phenylethyl) ({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}benzaldehyde,

2-methanesulfonyl-4-{3-[(2-phenylpropyl) ({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}benzaldehyde,

4-{3-[(2,2-diphenylethyl)({[2-fluoro-3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-methanesulfonylbenzaldehyde,

4-{3-[(2,2-diphenylethyl)({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-methanesulfonylbenzaldehyde,

4-{3-[benzyl({[2-chloro-3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-methanesulfonylbenzaldehyde,

4-{3-[benzyl({[2-fluoro-3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-methanesulfonylbenzaldehyde,

4-{3-[benzyl({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-methanesulfonylbenzaldehyde,

4-(3-{[(4-fluorophenyl)methyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-2-methanesulfonylbenzaldehyde,

4-(3-{[2-(4-fluorophenyl)-2-methylpropyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-2-methanesulfonylbenzaldehyde,

4-(3-{[2-(4-fluorophenyl)ethyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-2-methanesulfonylbenzaldehyde,

4-(3-{[2-(4-fluorophenyl)propyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-2-methanesulfonylbenzaldehyde,

4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[2,2-difluoro-2-(4-fluorophenyl)ethyl]amino)propoxy]-2-methanesulfonylbenzaldehyde,

4-(3-{[2,2-difluoro-2-(4-fluorophenyl)ethyl]({[2-fluoro-3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-2-methanesulfonylbenzaldehyde,

4-(3-{[2,2-difluoro-2-(4-fluorophenyl)ethyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-2-methanesulfonylbenzaldehyde,

4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2-methyl-2-phenylpropyl)amino)propoxy]-2-methanesulfonylbenzaldehyde,

4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2-phenylethyl)amino)propoxy]-2-methanesulfonylbenzaldehyde,

4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2-phenylpropyl)amino)propoxy]-2-methanesulfonylbenzaldehyde,

4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2,2-diphenylethyl)amino)propoxy]-2-methanesulfonylbenzaldehyde,

4-[3({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[(4-fluorophenyl)methyl]amino)propoxy]-2-methanesulfonylbenzaldehyde,

4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)-2-methylpropyl]amino)propoxy]-2-methanesulfonylbenzaldehyde,

4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)ethyl]amino)propoxy]-2-methanesulfonylbenzaldehyde,

4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)propyl]amino)propoxy]-2-methanesulfonylbenzaldehyde,

4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}(2-methyl-2-phenylpropyl)amino)propoxy]-2-methanesulfonylbenzaldehyde,

4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}(2-phenylethyl)amino)propoxy]-2-methanesulfonylbenzaldehyde,

4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}(2-phenylpropyl)amino)propoxy]-2-methanesulfonylbenzaldehyde,

4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[(4-fluorophenyl)methyl]amino)propoxy]-2-methanesulfonylbenzaldehyde,

4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)-2-methylpropyl]amino)propoxy]-2-methanesulfonylbenzaldehyde,

4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)ethyl]amino)propoxy]-2-methanesulfonylbenzaldehyde,

4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)propyl]amino)propoxy]-2-methanesulfonylbenzaldehyde,

methyl 2-fluoro-6-methanesulfonyl-4-{3-[(2-methyl-2-phenylpropyl)({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}benzoate,

methyl 2-fluoro-6-methanesulfonyl-4-{3-[(2-phenylpropyl)({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}benzoate,

methyl 4-{3-[(2,2-diphenylethyl)({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-fluoro-6-methanesulfonylbenzoate,

methyl 2-fluoro-6-methanesulfonyl-4-{3-[(2-phenylethyl)({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}benzoate,

methyl 4-{3-[(2,2-diphenylethyl)({[2-fluoro-3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-fluoro-6-methanesulfonylbenzoate,

methyl 4-{3-[benzyl({[2-chloro-3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-fluoro-6-methanesulfonylbenzoate,

methyl 4-{3-[benzyl({[2-fluoro-3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-fluoro-6-methanesulfonylbenzoate,

methyl 4-{3-[benzyl({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-fluoro-6-methanesulfonylbenzoate,

methyl 2-fluoro-4-(3-{[(4-fluorophenyl)methyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-6-methanesulfonylbenzoate,

methyl 2-fluoro-4-(3-{[2-(4-fluorophenyl)-2-methylpropyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-6-methanesulfonylbenzoate,

methyl 2-fluoro-4-(3-{[2-(4-fluorophenyl)ethyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-6-methanesulfonylbenzoate,

methyl 2-fluoro-4-(3-{[2-(4-fluorophenyl)propyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-6-methanesulfonylbenzoate,

methyl 4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[2,2-difluoro-2-(4-fluorophenyl)ethyl]amino)propoxy]-2-fluoro-6-methanesulfonylbenzoate,

methyl 4-(3-{[2,2-difluoro-2-(4-fluorophenyl)ethyl]({[2-fluoro-3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-2-fluoro-6-methanesulfonylbenzoate,

methyl 4-(3-{[2,2-difluoro-2-(4-fluorophenyl)ethyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-2-fluoro-6-methanesulfonylbenzoate,

methyl 4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2-methyl-2-phenylpropyl)amino)propoxy]-2-fluoro-6-methanesulfonylbenzoate,

methyl 4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2-phenylethyl)amino)propoxy]-2-fluoro-6-methanesulfonylbenzoate,

methyl 4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)-2-methylpropyl]amino)propoxy]-2-fluoro-6-methanesulfonylbenzoate,

methyl 4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[(4-fluorophenyl)methyl]amino)propoxy]-2-fluoro-6-methanesulfonylbenzoate,

methyl 4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2-phenylpropyl)amino)propoxy]-2-fluoro-6-methanesulfonylbenzoate,

methyl 4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)propyl]amino)propoxy]-2-fluoro-6-methanesulfonylbenzoate,

methyl 4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)ethyl]amino)propoxy]-2-fluoro-6-methanesulfonylbenzoate,

methyl 2-fluoro-4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}(2-methyl-2-phenylpropyl)amino)propoxy]-6-methanesulfonylbenzoate,

methyl 2-fluoro-4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}(2-phenylethyl)amino)propoxy]-6-methanesulfonylbenzoate,

methyl 2-fluoro-4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}(2-phenylpropyl)amino)propoxy]-6-methanesulfonylbenzoate,

methyl 2-fluoro-4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[(4-fluorophenyl)methyl]amino)propoxy]-6-methanesulfonylbenzoate,

methyl 2-fluoro-4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)-2-methylpropyl]amino)propoxy]-6-methanesulfonylbenzoate,

methyl 2-fluoro-4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)ethyl]amino)propoxy]-6-methanesulfonylbenzoate,

methyl 2-fluoro-4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)propyl]amino)propoxy]-6-methanesulfonylbenzoate,

methyl 2-methanesulfonyl-4-{3-[(2-methyl-2-phenylpropyl)({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}benzoate,

methyl 2-methanesulfonyl-4-{3-[(2-phenylethyl)({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}benzoate,

methyl 2-methanesulfonyl-4-{3-[(2-phenylpropyl)({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}benzoate,

methyl 4-{3-[(2,2-diphenylethyl)({[2-fluoro-3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-methanesulfonylbenzoate,

methyl 4-{3-[(2,2-diphenylethyl)({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-methanesulfonylbenzoate,

methyl 4-{3-[benzyl({[2-chloro-3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-methanesulfonylbenzoate,

methyl 4-{3-[benzyl({[2-fluoro-3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-methanesulfonylbenzoate,

methyl 4-{3-[benzyl({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-methanesulfonylbenzoate,

methyl 4-(3-{[(4-fluorophenyl)methyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-2-methanesulfonylbenzoate,

methyl 4-(3-{[2-(4-fluorophenyl)-2-methylpropyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-2-methanesulfonylbenzoate,

methyl 4-(3-{[2-(4-fluorophenyl)ethyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-2-methanesulfonylbenzoate,

methyl 4-(3-{[2-(4-fluorophenyl) propyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-2-methanesulfonylbenzoate,

methyl 4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[2,2-difluoro-2-(4-fluorophenyl)ethyl]amino)propoxy]-2-methanesulfonylbenzoate,

methyl 4-(3-{[2,2-difluoro-2-(4-fluorophenyl)ethyl]({[2-fluoro-3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-2-methanesulfonylbenzoate,

methyl 4-(3-{[2,2-difluoro-2-(4-fluorophenyl)ethyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-2-methanesulfonylbenzoate,

methyl 4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2-methyl-2-phenylpropyl)amino)propoxy]-2-methanesulfonylbenzoate,

methyl 4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2-phenylethyl)amino)propoxy]-2-methanesulfonylbenzoate,

methyl 4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2-phenylpropyl)amino)propoxy]-2-methanesulfonylbenzoate,

methyl 4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2,2-diphenylethyl)amino)propoxy]-2-methanesulfonylbenzoate,

methyl 4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[(4-fluorophenyl)methyl]amino)propoxy]-2-methanesulfonylbenzoate,

methyl 4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)-2-methylpropyl]amino)propoxy]-2-methanesulfonylbenzoate,

methyl 4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)ethyl]amino)propoxy]-2-methanesulfonylbenzoate,

methyl 4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)propyl]amino)propoxy]-2-methanesulfonylbenzoate,

methyl 4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}(2-methyl-2-phenylpropyl)amino)propoxy]-2-methanesulfonylbenzoate,

methyl 4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}(2-phenylethyl)amino)propoxy]-2-methanesulfonylbenzoate,

methyl 4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}(2-phenylpropyl)amino)propoxy]-2-methanesulfonylbenzoate,

methyl 4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[(4-fluorophenyl)methyl]amino)propoxy]-2-methanesulfonylbenzoate,

methyl 4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)-2-methylpropyl]amino)propoxy]-2-methanesulfonylbenzoate,

methyl 4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)ethyl]amino)propoxy]-2-methanesulfonylbenzoate,

methyl 4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)propyl]amino)propoxy]-2-methanesulfonylbenzoate,

2-(2-fluoro-6-methanesulfonyl-4-{3-[(2-phenylpropyl)({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}phenyl)ethan-1-ol,

2-(2-fluoro-6-methanesulfonyl-4-{3-[(2-phenylethyl)({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}phenyl)ethan-1-ol,

2-(2-fluoro-6-methanesulfonyl-4-{3-[(2-methyl-2-phenylpropyl)({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}phenyl)ethan-1-ol,

2-(4-{3-[(2,2-diphenylethyl)({[2-fluoro-3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-fluoro-6-methanesulfonylphenyl)ethan-1-ol,

2-(4-{3-[benzyl({[2-chloro-3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-fluoro-6-methanesulfonylphenyl)ethan-1-ol,

2-(4-{3-[benzyl({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-fluoro-6-methanesulfonylphenyl)ethan-1-ol,

2-(4-{3-[benzyl({[2-fluoro-3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-fluoro-6-methanesulfonylphenyl)ethan-1-ol,

2-[2-fluoro-4-(3-{[2-(4-fluorophenyl)ethyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-6-methanesulfonylphenyl]ethan-1-ol,

2-[2-fluoro-4-(3-{[2-(4-fluorophenyl)-2-methylpropyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-6-methanesulfonylphenyl]ethan-1-ol,

2-[2-fluoro-4-(3-{[2-(4-fluorophenyl)propyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-6-methanesulfonylphenyl]ethan-1-ol,

2-{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[2,2-difluoro-2-(4-fluorophenyl)ethyl]amino)propoxy]-2-fluoro-6-methanesulfonylphenyl}ethan-1-ol,

2-[2-fluoro-4-(3-{[(4-fluorophenyl)methyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-6-methanesulfonylphenyl]ethan-1-ol,

2-[4-(3-{[2,2-difluoro-2-(4-fluorophenyl)ethyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-2-fluoro-6-methanesulfonylphenyl]ethan-1-ol,

2-{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2-methyl-2-phenylpropyl)amino)propoxy]-2-fluoro-6-methanesulfonylphenyl}ethan-1-ol,

2-(4-{3-[(2,2-diphenylethyl)({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-fluoro-6-methanesulfonylphenyl)ethan-1-ol,

2-{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2-phenylethyl)amino)propoxy]-2-fluoro-6-methanesulfonylphenyl}ethan-1-ol,

2-{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2-phenylpropyl)amino)propoxy]-2-fluoro-6-methanesulfonylphenyl}ethan-1-ol,

2-{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)-2-methylpropyl]amino)propoxy]-2-fluoro-6-methanesulfonylphenyl}ethan-1-ol,

2-{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[(4-fluorophenyl)methyl]amino)propoxy]-2-fluoro-6-methanesulfonylphenyl}ethan-1-ol,

2-{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)ethyl]amino)propoxy]-2-fluoro-6-methanesulfonylphenyl}ethan-1-ol,

2-{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)propyl]amino)propoxy]-2-fluoro-6-methanesulfonylphenyl}ethan-1-ol,

2-{2-fluoro-4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}(2-methyl-2-phenylpropyl)amino)propoxy]-6-methanesulfonylphenyl}ethan-1-ol,

2-[4-(3-{[2,2-difluoro-2-(4-fluorophenyl)ethyl]({[2-fluoro-3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-2-fluoro-6-methanesulfonylphenyl]ethan-1-ol,

2-{2-fluoro-4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}(2-phenylpropyl)amino)propoxy]-6-methanesulfonylphenyl}ethan-1-ol,

2-{2-fluoro-4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[(4-fluorophenyl)methyl]amino)propoxy]-6-methanesulfonylphenyl}ethan-1-ol,

2-{2-fluoro-4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}(2-phenylethyl)amino)propoxy]-6-methanesulfonylphenyl}ethan-1-ol,

2-{2-fluoro-4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)-2-methylpropyl]amino)propoxy]-6-methanesulfonylphenyl}ethan-1-ol,

2-{2-fluoro-4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)ethyl]amino)propoxy]-6-methanesulfonylphenyl}ethan-1-ol,

2-{2-fluoro-4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)propyl]amino)propoxy]-6-methanesulfonylphenyl}ethan-1-ol,

2-(2-methanesulfonyl-4-{3-[(2-methyl-2-phenylpropyl)({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}phenyl)ethan-1-ol,

2-(2-methanesulfonyl-4-{3-[(2-phenylethyl)({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}phenyl)ethan-1-ol,

2-(2-methanesulfonyl-4-{3-[(2-phenylpropyl)({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}phenyl)ethan-1-ol,

2-(4-{3-[(2,2-diphenylethyl)({[2-fluoro-3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-methanesulfonylphenyl)ethan-1-ol,

2-(4-{3-[(2,2-diphenylethyl)({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-methanesulfonylphenyl)ethan-1-ol,

2-(4-{3-[benzyl({[2-chloro-3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-methanesulfonylphenyl)ethan-1-ol,

2-(4-{3-[benzyl({[2-fluoro-3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-methanesulfonylphenyl)ethan-1-ol,

2-(4-{3-[benzyl({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-methanesulfonylphenyl)ethan-1-ol,

2-[4-(3-{[(4-fluorophenyl)methyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-2-methanesulfonylphenyl]ethan-1-ol,

2-[4-(3-{[2-(4-fluorophenyl)-2-methylpropyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-2-methanesulfonylphenyl]ethan-1-ol,

2-[4-(3-{[2-(4-fluorophenyl)ethyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-2-methanesulfonylphenyl]ethan-1-ol,

2-[4-(3-{[2-(4-fluorophenyl)propyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-2-methanesulfonylphenyl]ethan-1-ol,

2-{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[2,2-difluoro-2-(4-fluorophenyl)ethyl]amino)propoxy]-2-methanesulfonylphenyl}ethan-1-ol,

2-[4-(3-{[2,2-difluoro-2-(4-fluorophenyl)ethyl]({[2-fluoro-3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-2-methanesulfonylphenyl]ethan-1-ol,

2-[4-(3-{[2,2-difluoro-2-(4-fluorophenyl)ethyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-2-methanesulfonylphenyl]ethan-1-ol,

2-{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2-methyl-2-phenylpropyl)amino)propoxy]-2-methanesulfonylphenyl}ethan-1-ol,

2-{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2-phenylethyl)amino)propoxy]-2-methanesulfonylphenyl}ethan-1-ol,

2-{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2-phenylpropyl)amino)propoxy]-2-methanesulfonylphenyl}ethan-1-ol,

2-{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2,2-diphenylethyl)amino)propoxy]-2-methanesulfonylphenyl}ethan-1-ol,

2-{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[(4-fluorophenyl)methyl]amino)propoxy]-2-methanesulfonylphenyl}ethan-1-ol,

2-{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)-2-methylpropyl]amino)propoxy]-2-methanesulfonylphenyl}ethan-1-ol,

2-{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)ethyl]amino)propoxy]-2-methanesulfonylphenyl}ethan-1-ol,

2-{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)propyl]amino)propoxy]-2-methanesulfonylphenyl}ethan-1-ol,

2-{4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}(2-methyl-2-phenylpropyl)amino)propoxy]-2-methanesulfonylphenyl}ethan-1-ol,

2-{4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}(2-phenylethyl)amino)propoxy]-2-methanesulfonylphenyl}ethan-1-ol,

2-{4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}(2-phenylpropyl)amino)propoxy]-2-methanesulfonylphenyl}ethan-1-ol,

2-{4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[(4-fluorophenyl)methyl]amino)propoxy]-2-methanesulfonylphenyl}ethan-1-ol,

2-{4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)-2-methylpropyl]amino)propoxy]-2-methanesulfonylphenyl}ethan-1-ol,

2-{4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)ethyl]amino)propoxy]-2-methanesulfonylphenyl}ethan-1-ol,

2-{4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)propyl]amino)propoxy]-2-methanesulfonylphenyl}ethan-1-ol,

2-(2-fluoro-6-methanesulfonyl-4-{3-[(2-phenylethyl)({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}phenyl)acetic acid,

2-(2-fluoro-6-methanesulfonyl-4-{3-[(2-phenylpropyl)({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}phenyl)acetic acid,

2-(4-{3-[(2,2-diphenylethyl)({[2-fluoro-3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-fluoro-6-methanesulfonylphenyl)acetic acid,

2-(4-{3-[benzyl({[2-chloro-3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-fluoro-6-methanesulfonylphenyl)acetic acid,

2-(4-{3-[benzyl({[2-fluoro-3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-fluoro-6-methanesulfonylphenyl)acetic acid,

2-(4-{3-[benzyl({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-fluoro-6-methanesulfonylphenyl)acetic acid,

2-[2-fluoro-4-(3-{[(4-fluorophenyl)methyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-6-methanesulfonylphenyl]acetic acid,

2-[2-fluoro-4-(3-{[2-(4-fluorophenyl)-2-methylpropyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-6-methanesulfonylphenyl]acetic acid,

2-[2-fluoro-4-(3-{[2-(4-fluorophenyl)ethyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-6-methanesulfonylphenyl]acetic acid,

2-[2-fluoro-4-(3-{[2-(4-fluorophenyl)propyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-6-methanesulfonylphenyl]acetic acid,

2-{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[2,2-difluoro-2-(4-fluorophenyl)ethyl]amino)propoxy]-2-fluoro-6-methanesulfonylphenyl}acetic acid,

2-[4-(3-{[2,2-difluoro-2-(4-fluorophenyl)ethyl]({[2-fluoro-3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-2-fluoro-6-methanesulfonylphenyl]acetic acid,

2-[4-(3-{[2,2-difluoro-2-(4-fluorophenyl)ethyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-2-fluoro-6-methanesulfonylphenyl]acetic acid,

2-{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2-methyl-2-phenylpropyl)amino)propoxy]-2-fluoro-6-methanesulfonylphenyl}acetic acid,

2-{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2-phenylethyl)amino)propoxy]-2-fluoro-6-methanesulfonylphenyl}acetic acid,

2-{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2-phenylpropyl)amino)propoxy]-2-fluoro-6-methanesulfonylphenyl}acetic acid,

2-{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2,2-diphenylethyl)amino)propoxy]-2-fluoro-6-methanesulfonylphenyl}acetic acid,

2-{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[(4-fluorophenyl)methyl]amino)propoxy]-2-fluoro-6-methanesulfonylphenyl}acetic acid,

2-{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)-2-methylpropyl]amino)propoxy]-2-fluoro-6-methanesulfonylphenyl}acetic acid,

2-{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)ethyl]amino)propoxy]-2-fluoro-6-methanesulfonylphenyl}acetic acid,

2-{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)propyl]amino)propoxy]-2-fluoro-6-methanesulfonylphenyl}acetic acid,

2-(4-{3-[(2,2-diphenylethyl)({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-fluoro-6-methanesulfonylphenyl)acetic acid,

2-{2-fluoro-4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}(2-methyl-2-phenylpropyl)amino)propoxy]-6-methanesulfonylphenyl}acetic acid,

2-(2-fluoro-6-methanesulfonyl-4-{3-[(2-methyl-2-phenylpropyl)({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}phenyl)acetic acid,

2-{2-fluoro-4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}(2-phenylpropyl)amino)propoxy]-6-methanesulfonylphenyl}acetic acid,

2-{2-fluoro-4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[(4-fluorophenyl)methyl]amino)propoxy]-6-methanesulfonylphenyl}acetic acid,

2-{2-fluoro-4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)-2-methylpropyl]amino)propoxy]-6-methanesulfonylphenyl}acetic acid,

2-{2-fluoro-4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)ethyl]amino)propoxy]-6-methanesulfonylphenyl}acetic acid,

2-{2-fluoro-4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}(2-phenylethyl)amino)propoxy]-6-methanesulfonylphenyl}acetic acid,

2-{2-fluoro-4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)propyl]amino)propoxy]-6-methanesulfonylphenyl}acetic acid,

2-(2-methanesulfonyl-4-{3-[(2-methyl-2-phenylpropyl)({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}phenyl)acetic acid,

2-(2-methanesulfonyl-4-{3-[(2-phenylethyl)({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}phenyl)acetic acid,

2-(2-methanesulfonyl-4-{3-[(2-phenylpropyl)({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}phenyl)acetic acid,

2-(4-{3-[(2,2-diphenylethyl)({[2-fluoro-3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-methanesulfonylphenyl)acetic acid,

2-(4-{3-[(2,2-diphenylethyl)({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-methanesulfonylphenyl)acetic acid,

2-(4-{3-[benzyl({[2-chloro-3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-methanesulfonylphenyl)acetic acid,

2-(4-{3-[benzyl({[2-fluoro-3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-methanesulfonylphenyl)acetic acid,

2-(4-{3-[benzyl({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-methanesulfonylphenyl)acetic acid,

2-[4-(3-{[(4-fluorophenyl)methyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-2-methanesulfonylphenyl]acetic acid,

2-[4-(3-{[2-(4-fluorophenyl)-2-methylpropyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-2-methanesulfonylphenyl]acetic acid,

2-[4-(3-{[2-(4-fluorophenyl)ethyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-2-methanesulfonylphenyl]acetic acid,

2-[4-(3-{[2-(4-fluorophenyl)propyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-2-methanesulfonylphenyl]acetic acid,

2-{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[2,2-difluoro-2-(4-fluorophenyl)ethyl]amino)propoxy]-2-methanesulfonylphenyl}acetic acid,

2-[4-(3-{[2,2-difluoro-2-(4-fluorophenyl)ethyl]({[2-fluoro-3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-2-methanesulfonylphenyl]acetic acid,

2-[4-(3-{[2,2-difluoro-2-(4-fluorophenyl)ethyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-2-methanesulfonylphenyl]acetic acid,

2-{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2-methyl-2-phenylpropyl)amino)propoxy]-2-methanesulfonylphenyl}acetic acid,

2-{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2-phenylethyl)amino)propoxy]-2-methanesulfonylphenyl}acetic acid,

2-{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2-phenylpropyl)amino)propoxy]-2-methanesulfonylphenyl}acetic acid,

2-{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2,2-diphenylethyl)amino)propoxy]-2-methanesulfonylphenyl}acetic acid,

2-{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[(4-fluorophenyl)methyl]amino)propoxy]-2-methanesulfonylphenyl}acetic acid,

2-{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)-2-methylpropyl]amino)propoxy]-2-methanesulfonylphenyl}acetic acid,

2-{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)ethyl]amino)propoxy]-2-methanesulfonylphenyl}acetic acid,

2-{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)propyl]amino)propoxy]-2-methanesulfonylphenyl}acetic acid,

2-{4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}(2-methyl-2-phenylpropyl)amino)propoxy]-2-methanesulfonylphenyl}acetic acid,

2-{4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}(2-phenylethyl)amino)propoxy]-2-methanesulfonylphenyl}acetic acid,

2-{4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}(2-phenylpropyl)amino)propoxy]-2-methanesulfonylphenyl}acetic acid,

2-{4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[(4-fluorophenyl)methyl]amino)propoxy]-2-methanesulfonylphenyl}acetic acid,

2-{4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)-2-methylpropyl]amino)propoxy]-2-methanesulfonylphenyl}acetic acid,

2-{4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)ethyl]amino)propoxy]-2-methanesulfonylphenyl}acetic acid,

2-{4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)propyl]amino)propoxy]-2-methanesulfonylphenyl}acetic acid,

N-[(2-fluoro-6-methanesulfonyl-4-{3-[(2-phenylethyl)({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}phenyl)methyl]acetamide,

N-[(4-{3-[(2,2-diphenylethyl)({[2-fluoro-3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-fluoro-6-methanesulfonylphenyl)methyl]acetamide,

N-[(2-fluoro-6-methanesulfonyl-4-{3-[(2-phenylpropyl)({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}phenyl)methyl]acetamide,

N-[(2-fluoro-6-methanesulfonyl-4-{3-[(2-methyl-2-phenylpropyl)({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}phenyl) methyl]acetamide,

N-[(4-{3-[(2,2-diphenylethyl)({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-fluoro-6-methanesulfonylphenyl)methyl]acetamide,

N-[(4-{3-[benzyl({[2-chloro-3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-fluoro-6-methanesulfonylphenyl)methyl]acetamide,

N-[(4-{3-[benzyl({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-fluoro-6-methanesulfonylphenyl)methyl]acetamide,

N-{[2-fluoro-4-(3-{[(4-fluorophenyl)methyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-6-methanesulfonylphenyl]methyl}acetamide,

N-{[2-fluoro-4-(3-{[2-(4-fluorophenyl)-2-methylpropyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-6-methanesulfonylphenyl]methyl}acetamide,

N-{[2-fluoro-4-(3-{[2-(4-fluorophenyl)propyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-6-methanesulfonylphenyl]methyl}acetamide,

N-{[4-(3-{[2,2-difluoro-2-(4-fluorophenyl)ethyl]({[2-fluoro-3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-2-fluoro-6-methanesulfonylphenyl]methyl}acetamide,

N-({4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[2,2-difluoro-2-(4-fluorophenyl)ethyl]amino)propoxy]-2-fluoro-6-methanesulfonylphenyl}methyl)acetamide,

N-{[4-(3-{[2,2-difluoro-2-(4-fluorophenyl)ethyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-2-fluoro-6-methanesulfonylphenyl]methyl}acetamide,

N-({4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2-methyl-2-phenylpropyl)amino)propoxy]-2-fluoro-6-methanesulfonylphenyl}methyl)acetamide,

N-({4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2-phenylethyl)amino)propoxy]-2-fluoro-6-methanesulfonylphenyl}methyl)acetamide,

N-({4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2-phenylpropyl)amino)propoxy]-2-fluoro-6-methanesulfonylphenyl}methyl)acetamide,

N-({4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[(4-fluorophenyl)methyl]amino)propoxy]-2-fluoro-6-methanesulfonylphenyl}methyl)acetamide,

N-({4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)-2-methylpropyl]amino)propoxy]-2-fluoro-6-methanesulfonylphenyl}methyl)acetamide,

N-({4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)ethyl]amino)propoxy]-2-fluoro-6-methanesulfonylphenyl}methyl)acetamide,

N-({4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)propyl]amino)propoxy]-2-fluoro-6-methanesulfonylphenyl}methyl)acetamide,

N-({2-fluoro-4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}(2-methyl-2-phenylpropyl)amino)propoxy]-6-methanesulfonylphenyl}methyl)acetamide,

N-({2-fluoro-4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}(2-phenylethyl)amino)propoxy]-6-methanesulfonylphenyl}methyl)acetamide,

N-({2-fluoro-4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}(2-phenylpropyl)amino)propoxy]-6-methanesulfonylphenyl}methyl)acetamide,

N-{[2-fluoro-4-(3-{[2-(4-fluorophenyl)ethyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-6-methanesulfonylphenyl]methyl}acetamide,

N-[(4-{3-[benzyl({[2-fluoro-3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-fluoro-6-methanesulfonylphenyl)methyl]acetamide,

N-({2-fluoro-4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[(4-fluorophenyl)methyl]amino)propoxy]-6-methanesulfonylphenyl}methyl)acetamide,

N-({2-fluoro-4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)-2-methylpropyl]amino)propoxy]-6-methanesulfonylphenyl}methyl)acetamide,

N-({2-fluoro-4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)ethyl]amino)propoxy]-6-methanesulfonylphenyl}methyl)acetamide,

N-({2-fluoro-4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)propyl]amino)propoxy]-6-methanesulfonylphenyl}methyl)acetamide,

N-[(2-methanesulfonyl-4-{3-[(2-methyl-2-phenylpropyl) ({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}phenyl)methyl]acetamide,

N-[(2-methanesulfonyl-4-{3-[(2-phenylethyl) ({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}phenyl) methyl]acetamide,

N-[(2-methanesulfonyl-4-{3-[(2-phenylpropyl)({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}phenyl)methyl]acetamide,

N-[(4-{3-[(2,2-diphenylethyl)({[2-fluoro-3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-methanesulfonylphenyl)methyl]acetamide,

N-[(4-{3-[(2,2-diphenylethyl)({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-methanesulfonylphenyl)methyl]acetamide,

N-[(4-{3-[benzyl({[2-chloro-3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-methanesulfonylphenyl)methyl]acetamide,

N-[(4-{3-[benzyl({[2-fluoro-3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-methanesulfonylphenyl)methyl]acetamide,

N-[(4-{3-[benzyl({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-methanesulfonylphenyl)methyl]acetamide,

N-{[4-(3-{[(4-fluorophenyl)methyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-2-methanesulfonylphenyl]methyl}acetamide,

N-{[4-(3-{[2-(4-fluorophenyl)-2-methylpropyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-2-methanesulfonylphenyl]methyl}acetamide,

N-{[4-(3-{[2-(4-fluorophenyl)ethyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-2-methanesulfonylphenyl]methyl}acetamide,

N-{[4-(3-{[2-(4-fluorophenyl)propyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-2-methanesulfonylphenyl]methyl}acetamide,

N-({4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[2,2-difluoro-2-(4-fluorophenyl)ethyl]amino)propoxy]-2-methanesulfonylphenyl}methyl)acetamide,

N-{[4-(3-{[2,2-difluoro-2-(4-fluorophenyl)ethyl]({[2-fluoro-3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-2-methanesulfonylphenyl]methyl}acetamide,

N-{[4-(3-{[2,2-difluoro-2-(4-fluorophenyl)ethyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-2-methanesulfonylphenyl]methyl}acetamide,

N-({4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2-methyl-2-phenylpropyl)amino)propoxy]-2-methanesulfonylphenyl}methyl)acetamide,

N-({4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2-phenylethyl)amino)propoxy]-2-methanesulfonylphenyl}methyl)acetamide,

N-({4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2-phenylpropyl)amino)propoxy]-2-methanesulfonylphenyl}methyl)acetamide,

N-({4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2,2-diphenylethyl)amino)propoxy]-2-methanesulfonylphenyl}methyl)acetamide,

N-({4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[(4-fluorophenyl)methyl]amino)propoxy]-2-methanesulfonylphenyl}methyl)acetamide,

N-({4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)-2-methylpropyl]amino)propoxy]-2-methanesulfonylphenyl}methyl)acetamide,

N-({4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)ethyl]amino)propoxy]-2-methanesulfonylphenyl}methyl)acetamide,

N-({4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)propyl]amino)propoxy]-2-methanesulfonylphenyl}methyl)acetamide,

N-({4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}(2-methyl-2-phenylpropyl)amino)propoxy]-2-methanesulfonylphenyl}methyl)acetamide,

N-({4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}(2-phenylethyl)amino)propoxy]-2-methanesulfonylphenyl}methyl)acetamide,

N-({4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}(2-phenylpropyl)amino)propoxy]-2-methanesulfonylphenyl}methyl)acetamide,

N-({4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[(4-fluorophenyl)methyl]amino)propoxy]-2-methanesulfonylphenyl}methyl)acetamide,

N-({4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)-2-methylpropyl]amino)propoxy]-2-methanesulfonylphenyl}methyl)acetamide,

N-({4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)ethyl]amino)propoxy]-2-methanesulfonylphenyl}methyl)acetamide,

N-({4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)propyl]amino)propoxy]-2-methanesulfonylphenyl}methyl)acetamide,

2-(2-fluoro-6-methanesulfonyl-4-{3-[(2-methyl-2-phenylpropyl)({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}phenyl)propan-2-ol,

2-(2-fluoro-6-methanesulfonyl-4-{3-[(2-phenylethyl)({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}phenyl)propan-2-ol,

2-(2-fluoro-6-methanesulfonyl-4-{3-[(2-phenylpropyl)({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}phenyl)propan-2-ol,

2-(4-{3-[(2,2-diphenylethyl)({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-fluoro-6-methanesulfonylphenyl) propan-2-ol,

2-(4-{3-[benzyl({[2-chloro-3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-fluoro-6-methanesulfonylphenyl)propan-2-ol,

2-(4-{3-[benzyl({[2-fluoro-3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-fluoro-6-methanesulfonylphenyl)propan-2-ol,

2-(4-{3-[benzyl({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-fluoro-6-methanesulfonylphenyl)propan-2-ol,

2-(4-{3-[(2,2-diphenylethyl)({[2-fluoro-3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-fluoro-6-methanesulfonylphenyl)propan-2-ol,

2-[2-fluoro-4-(3-{[(4-fluorophenyl)methyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-6-methanesulfonylphenyl]propan-2-ol,

2-[2-fluoro-4-(3-{[2-(4-fluorophenyl)ethyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-6-methanesulfonylphenyl]propan-2-ol,

2-[2-fluoro-4-(3-{[2-(4-fluorophenyl)-2-methylpropyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-6-methanesulfonylphenyl]propan-2-ol,

2-[2-fluoro-4-(3-{[2-(4-fluorophenyl)propyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-6-methanesulfonylphenyl]propan-2-ol,

2-{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[2,2-difluoro-2-(4-fluorophenyl)ethyl]amino)propoxy]-2-fluoro-6-methanesulfonylphenyl}propan-2-ol,

2-[4-(3-{[2,2-difluoro-2-(4-fluorophenyl)ethyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-2-fluoro-6-methanesulfonylphenyl]propan-2-ol,

2-[4-(3-{[2,2-difluoro-2-(4-fluorophenyl)ethyl]({[2-fluoro-3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-2-fluoro-6-methanesulfonylphenyl]propan-2-ol,

2-{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2-methyl-2-phenylpropyl)amino)propoxy]-2-fluoro-6-methanesulfonylphenyl}propan-2-ol,

2-{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2-phenylethyl)amino)propoxy]-2-fluoro-6-methanesulfonylphenyl}propan-2-ol,

2-{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[(4-fluorophenyl)methyl]amino)propoxy]-2-fluoro-6-methanesulfonylphenyl}propan-2-ol,

2-{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2-phenylpropyl)amino)propoxy]-2-fluoro-6-methanesulfonylphenyl}propan-2-ol,

2-{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)-2-methylpropyl]amino)propoxy]-2-fluoro-6-methanesulfonylphenyl}propan-2-ol,

2-{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)ethyl]amino)propoxy]-2-fluoro-6-methanesulfonylphenyl}propan-2-ol,

2-{2-fluoro-4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}(2-methyl-2-phenylpropyl)amino)propoxy]-6-methanesulfonylphenyl}propan-2-ol,

2-{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)propyl]amino)propoxy]-2-fluoro-6-methanesulfonylphenyl}propan-2-ol,

2-{2-fluoro-4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}(2-phenylethyl)amino)propoxy]-6-methanesulfonylphenyl}propan-2-ol,

2-{2-fluoro-4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}(2-phenylpropyl)amino)propoxy]-6-methanesulfonylphenyl}propan-2-ol,

2-{2-fluoro-4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[(4-fluorophenyl)methyl]amino)propoxy]-6-methanesulfonylphenyl}propan-2-ol,

2-{2-fluoro-4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)-2-methylpropyl]amino)propoxy]-6-methanesulfonylphenyl}propan-2-ol,

2-{2-fluoro-4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)ethyl]amino)propoxy]-6-methanesulfonylphenyl}propan-2-ol,

2-{2-fluoro-4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)propyl]amino)propoxy]-6-methanesulfonylphenyl}propan-2-ol,

2-(2-methanesulfonyl-4-{3-[(2-methyl-2-phenylpropyl)({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}phenyl)propan-2-ol,

2-(2-methanesulfonyl-4-{3-[(2-phenylethyl)({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}phenyl)propan-2-ol,

2-(2-methanesulfonyl-4-{3-[(2-phenylpropyl)({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}phenyl)propan-2-ol,

2-(4-{3-[(2,2-diphenylethyl)({[2-fluoro-3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-methanesulfonylphenyl)propan-2-ol,

2-(4-{3-[(2,2-diphenylethyl)({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-methanesulfonylphenyl)propan-2-ol,

2-(4-{3-[benzyl({[2-chloro-3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-methanesulfonylphenyl)propan-2-ol,

2-(4-{3-[benzyl({[2-fluoro-3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-methanesulfonylphenyl)propan-2-ol,

2-(4-{3-[benzyl({[3-(trifluoromethyl)phenyl]methyl})amino]propoxy}-2-methanesulfonylphenyl)propan-2-ol,

2-[4-(3-{[(4-fluorophenyl)methyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-2-methanesulfonylphenyl]propan-2-ol,

2-[4-(3-{[2-(4-fluorophenyl)-2-methylpropyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-2-methanesulfonylphenyl]propan-2-ol,

2-[4-(3-{[2-(4-fluorophenyl)ethyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-2-methanesulfonylphenyl]propan-2-ol,

2-[4-(3-{[2-(4-fluorophenyl)propyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-2-methanesulfonylphenyl]propan-2-ol,

2-{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[2,2-difluoro-2-(4-fluorophenyl)ethyl]amino)propoxy]-2-methanesulfonylphenyl}propan-2-ol,

2-[4-(3-{[2,2-difluoro-2-(4-fluorophenyl)ethyl]({[2-fluoro-3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-2-methanesulfonylphenyl]propan-2-ol,

2-[4-(3-{[2,2-difluoro-2-(4-fluorophenyl)ethyl]({[3-(trifluoromethyl)phenyl]methyl})amino}propoxy)-2-methanesulfonylphenyl]propan-2-ol,

2-{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2-methyl-2-phenylpropyl)amino)propoxy]-2-methanesulfonylphenyl}propan-2-ol,

2-{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2-phenylethyl)amino)propoxy]-2-methanesulfonylphenyl}propan-2-ol,

2-{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2-phenylpropyl)amino)propoxy]-2-methanesulfonylphenyl}propan-2-ol,

2-{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[(4-fluorophenyl)methyl]amino)propoxy]-2-methanesulfonylphenyl}propan-2-ol,

2-{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)-2-methylpropyl]amino)propoxy]-2-methanesulfonylphenyl}propan-2-ol,

2-{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)ethyl]amino)propoxy]-2-methanesulfonylphenyl}propan-2-ol,

2-{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)propyl]amino)propoxy]-2-methanesulfonylphenyl}propan-2-ol,

2-{4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}(2-methyl-2-phenylpropyl)amino)propoxy]-2-methanesulfonylphenyl}propan-2-ol,

2-{4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}(2-phenylethyl)amino)propoxy]-2-methanesulfonylphenyl}propan-2-ol,

2-{4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}(2-phenylpropyl)amino)propoxy]-2-methanesulfonylphenyl}propan-2-ol,

2-{4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[(4-fluorophenyl)methyl]amino)propoxy]-2-methanesulfonylphenyl}propan-2-ol,

2-{4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)-2-methylpropyl]amino)propoxy]-2-methanesulfonylphenyl}propan-2-ol,

2-{4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)ethyl]amino)propoxy]-2-methanesulfonylphenyl}propan-2-ol,

2-{4-[3-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}[2-(4-fluorophenyl)propyl]amino)propoxy]-2-methanesulfonylphenyl}propan-2-ol, and

2-{4-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2,2-diphenylethyl)amino)propoxy]-2-methanesulfonylphenyl}propan-2-ol.

14. The compound of claim 1 , wherein at least one of R A or R B is optionally substituted C 1 -C 6 heteroalkyl, wherein the optionally substituted C 1 -C 6 heteroalkyl is —OR V , wherein R V is:

wherein each R′ and R″ is independently hydrogen, optionally substituted C 1 -C 6 alkyl, or optionally substituted C 6 -C 10 aryl C 1 -C 6 alkyl.

15. A method of ameliorating one or more symptoms of cancer comprising administering an effective amount of a compound of claim 1 , or pharmaceutically acceptable salts thereof to a subject in need thereof.

16. A method of ameliorating one or more symptoms of cancer comprising contacting a cell with an effective amount of a compound of claim 1 , or pharmaceutically acceptable salts thereof.

17. The method of claim 15 , wherein said cancer is breast cancer, colon cancer, renal cell cancer, non-small cell lung cancer, hepatocellular carcinoma, gastric cancer, ovarian cancer, pancreatic cancer, esophageal cancer, prostate cancer, sarcoma, glioblastoma, diffuse large B-cell lymphoma, acute myeloid leukemia, multiple myeloma, or melanoma.

18. The method of claim 15 , wherein said method further comprises administration of an additional anticancer therapy.

19. The method of ameliorating one or more symptoms of a neurological disorder comprising administering an effective amount of a compound of claim 1 , or pharmaceutically acceptable salts thereof to a subject in nee thereof, wherein said neurological disorder is Alzheimer's disease.

Assignments (5)
CHANGE OF NAME Recorded Sep 17, 2021
From: RGENIX, INC.
To: INSPIRNA, INC.
Reel/Frame 057537/0973 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 27, 2019
From: ESCIENTIA LIFE SCIENCES, LLC
To: RGENIX, INC.
Reel/Frame 050579/0847 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 26, 2019
From: KAISER, BERND
To: ESCIENTIA LIFE SCIENCES, LLC
Reel/Frame 050496/0812 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 30, 2019
From: TAVAZOIE, SOHAIL F.; KURTH, ISABEL; GONSALVES, FOSTER CASIMIR; DARST, DAVID M., JR.; TAVAZOIE, MASOUD FAKHR
To: RGENIX, INC.
Reel/Frame 048189/0947 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 19, 2018
From: MARTINEZ, EDUARDO J.
To: RGENIX, INC.
Reel/Frame 046908/0445 →
Continuity (2)
Provisional Application 61926150 · Jan 10, 2014
Related Publication 20170066791A1 · Mar 9, 2017
Cited By (2)
US 12,258,303 US 12,427,149