Material to form a hydrogel
A soft film, a sponge, or a sheet in the dried state is provided, which is capable of forming a hydrogel absorbing water or blood. The film is obtainable by preparing a film-state material in the dried state from either a solution of poly(acrylic acid) or a solution of polyvinylpyrrolidone, and bringing the film-state material into contact with the other remaining solution, and then drying or freeze-drying it.
1. A method for producing a freeze-dried sheet including poly(acrylic acid) and polyvinylpyrrolidone, the method comprising:
preparing a film-state material in a dried state from either a solution of poly(acrylic acid) or a solution of polyvinylpyrrolidone; and
bringing the film-state material into contact with the other remaining solution, followed by being frozen and then being freeze-dried,
wherein the freeze-dried sheet forms a hydrogel having adhesiveness to a bio-tissue when the freeze-dried sheet absorbs water or blood.
2. The method according to claim 1 , the method comprising:
preparing the film-state material in the dried state from the solution of poly(acrylic acid); and
bringing the film-state material into contact with the solution of polyvinylpyrrolidone, followed by being frozen and then being freeze-dried.
3. The method according to claim 1 , wherein one of or both of the solutions of poly(acrylic acid) and polyvinylpyrrolidone include(s) a water-soluble polymer.
4. The method according to claim 3 , wherein the water-soluble polymer is selected from the group consisting of hydroxyethyl cellulose, carboxymethyl cellulose, hydroxypropyl methylcellulose, chondroitin sulfate, pectin, Locust bean gum, gum guaic, xanthum gum, Whelan, poly(vinylalcohol), hyaluronic acid, polyethylene glycol, and chitosan.
5. The method according to claim 1 , wherein a repeating unit molar ratio of either poly(acrylic acid) or polyvinylpyrrolidone included in the film-state material to poly(acrylic acid) or polyvinylpyrrolidone in the other remaining solution to be used for contacting is at the range of 0.1 or more to 10 or less.
6. The method according to claim 1 , wherein the freeze-dried sheet is a medical treatment material or a component thereof.
7. The method according to claim 6 , wherein the medical treatment material is an adhesion barrier or a hemostatic device.
8. The method according to claim 6 , wherein the medical treatment material is a wound covering material.