Multi-sensor non-invasive blood glucose monitoring instrument based on impedance spectroscopy-optical method

1. A multi-sensor non-invasive blood glucose monitoring instrument based on impedance spectroscopy optics, the monitoring instrument comprising:

a detection probe;

a microprocessor;

a display unit; and

a storage unit,

wherein the detection probe comprises a pair of high-frequency electrodes, a pair of low-frequency electrodes, a temperature and humidity sensor, an LED array, a photoelectric sensor, and a contact plate,

wherein the microprocessor controls an excitation signal generation circuit to generate high frequency and low frequency excitation signals,

wherein feedback signals from the high-frequency electrodes and the low-frequency electrodes are inputted to the microprocessor via an amplitude and phase detection circuit, and then high-frequency impedance and low-frequency impedance are obtained through calculation,

wherein temperature signals and humidity signals of a tested part are measured with the temperature and humidity sensor, and then are conditioned and inputted to the microprocessor,

wherein the LED array is controlled by a transmitter control circuit,

wherein light intensity signals measured by the photoelectric sensor are amplified and filtered, and then inputted to the microprocessor to obtain optical characteristics of tissue of the tested part,

wherein the microprocessor is configured to use a model to calculate a blood glucose concentration of the test part based on the optical characteristics, the high-frequency impedance and low-frequency impedance, and the conditioned temperature signals and humidity signals,

wherein the microprocessor outputs the calculated blood glucose concentration to the display unit for display, and the optical characteristics, the high-frequency impedance and low-frequency impedance, and the conditioned temperature signals and humidity signals are saved in the storage unit at the same time,

wherein the high-frequency electrodes comprise a pair of parallel electrodes, and a matching inductor L is directly soldered to one of the electrodes,

wherein a distance between a positive electrode and a negative electrode of the low-frequency electrodes is 1 cm-2 m,

wherein a vertical distance from a bottom of the temperature and humidity sensor to a bottom of the contact plate is 0.1 mm-20 mm, and

wherein the temperature and humidity sensor and the tested part form an enclosed space, and slits or pores are arranged in a wall of the enclosed space to form a balanced heat and moisture storage structure.

2. The monitoring instrument according to claim 1 , wherein a shielding electrode is provided around the high-frequency electrodes, and the shielding electrode is connected to a positive electrode or a negative electrode of the high-frequency electrodes via the matching inductor L.

3. The monitoring instrument according to claim 1 , wherein the low-frequency electrodes adopt a split design.

4. The monitoring instrument according to claim 1 , wherein, wherein the high-frequency electrodes are flexible electrodes.

5. The monitoring instrument according to claim 1 , wherein the enclosed space between the temperature and humidity sensor and the tested part is formed by a sensor mounting plate and a base plate with a cavity structure, and wherein the base plate is mounted on top of the contact plate.

6. The monitoring instrument according to claim 1 , wherein a center distance between the LED array and the photoelectric sensor is 1 mm-200 mm.

7. The monitoring instrument according to claim 1 , wherein the LED array comprises 4 LEDs, the wavelengths of which are 660 nm, 760 nm, 850 nm and 940 nm, respectively.

8. The monitoring instrument according to claim 1 , wherein the detection probe is fixed to the tested part via a wrist strap.

9. The monitoring instrument according to claim 1 , wherein the contact plate is a rubber plate.