Polyacrylamide hydrogel for use in the prevention and/or treatment of synovitis in a mammal
The present invention relates to a polyacrylamide hydrogel for use in prevention and/or treatment of synovitis or pain associated with synovitis in a mammal by formation of an extra layer to the synovial membrane i.e. a sub-synovial layer and a novel synovial lining layer. Synovitis may occur in association with arthritis, such as osteoarthritis or rheumatoid arthritis, lupus, or gout, and the mammal suffering from synovitis is a preferably a human, a racing animal or a companion animal.
1. A method of ameliorating synovitis in a mammal comprising:
selecting a mammal to receive a sub-synovial layer or a novel synovial lining layer; and
administering a polyacrylamide hydrogel to an intraarticular cavity of the mammal to generate the sub-synovial layer or novel synovial lining layer comprising said polyacrylamide hydrogel.
2. The method according to claim 1 , wherein the sub-synovial layer or the novel synovial lining layer persists for up to 15 months.
3. The method according to claim 1 , wherein the polyacrylamide hydrogel is administered by injection under sterile conditions.
4. The method according to claim 1 , wherein the polyacrylamide hydrogel is administered by intraarticular injection.
5. The method according to claim 1 , wherein 0.1-20 ml polyacrylamide hydrogel is administered by injection into the intraarticular cavity.
6. The method according to claim 1 , wherein 0.1-20 ml polyacrylamide hydrogel is administered by injection into the intraarticular cavity at least twice.
7. The method according to claim 1 , wherein 0.1-20 ml polyacrylamide hydrogel is administered by injection into the intraarticular cavity at regular intervals.
8. The method according to claim 1 , wherein the mammal is a human, a racing animal or a companion animal.
9. The method of claim 1 , wherein the mammal is a human and the polyacrylamide hydrogel is administered to a joint selected from the group consisting of a knee, a hip, an elbow, a metacarpal-phalangeal and interphalangeal joint in hands or feet, a sesamoid joint and the temporomandibular joint.
10. The method according to claim 1 , wherein the mammal is a horse and the polyacrylamide hydrogel is administered to a fetlock, coffin, pastern, stifle, or knee joint of the hind leg.
11. The method according to claim 1 , wherein the mammal is a dog and the polyacrylamide hydrogel is administered to the elbow of the front leg or the knee or hip joint of the hind leg.
12. The method of claim 1 , wherein the mammal is suffering from arthritis, osteoarthritis, rheumatoid arthritis, lupus, or gout.
13. The method according to claim 12 , wherein the mammal is suffering from osteoarthritis or rheumatoid arthritis.
14. A method of ameliorating synovitis in a mammal comprising:
administering a polyacrylamide hydrogel to an intraarticular cavity of a mammal to generate a sub-synovial layer or a novel synovial lining layer comprising said polyacrylamide hydrogel; and
evaluating said mammal for the formation of the sub-synovial layer or the novel synovial lining layer.
15. The method according to claim 14 , wherein the sub-synovial layer or the novel synovial lining layer persists for up to 15 months.
16. The method according to claim 14 , wherein the polyacrylamide hydrogel is administered by injection under sterile conditions.
17. The method according to claim 14 , wherein the polyacrylamide hydrogel is administered by intraarticular injection.
18. The method according to claim 14 , wherein 0.1-20 ml polyacrylamide hydrogel is administered by injection into the intraarticular cavity.
19. The method according to claim 14 , wherein 0.1-20 ml polyacrylamide hydrogel is administered by injection into the intraarticular cavity at least twice.
20. The method according to claim 14 , wherein 0.1-20 ml polyacrylamide hydrogel is administered by injection into the intraarticular cavity at regular intervals.
21. The method according to claim 14 , wherein the mammal is a human, a racing animal or a companion animal.
22. The method of claim 14 , wherein the mammal is a human and the polyacrylamide hydrogel is administered to a joint selected from the group consisting of a knee, a hip, an elbow, a metacarpal-phalangeal and interphalangeal joint in hands or feet, a sesamoid joint and the temporomandibular joint.
23. The method according to claim 14 , wherein the mammal is a horse and the polyacrylamide hydrogel is administered to a fetlock, coffin, pastern, stifle, or knee joint of the hind leg.
24. The method according to claim 14 , wherein the mammal is a dog and the polyacrylamide hydrogel is administered to the elbow of the front leg or the knee or hip joint of the hind leg.
25. The method of claim 14 , wherein the mammal is suffering from arthritis, osteoarthritis, rheumatoid arthritis, lupus, or gout.
26. The method according to claim 25 , wherein the mammal is suffering from osteoarthritis or rheumatoid arthritis.