Method and system for controlling patient sedation and spontaneous breathing intensity

1. A system for controlling patient sedation and spontaneous breathing intensity, the system comprising:

a ventilator system comprising:

a ventilator circuit that outputs breathing gas from a gas supply to a patient and receives expiration gas from the patient;

a spontaneous breathing control module executable on a processor and configured to:

determine a first spontaneous breathing intensity at a first sedative status of the patient;

determine a second spontaneous breathing intensity at a second sedative status of the patient;

define a sedation/breathing relationship between spontaneous breathing intensity and sedative status for the patient based on the first sedative status and the first spontaneous breathing intensity, and the second sedative status and the second spontaneous breathing intensity;

receive a desired spontaneous breathing intensity;

determine a desired sedative status to achieve the desired spontaneous breathing intensity based on the sedation/breathing relationship; and

generate an output related to the desired sedative status that achieves the desired spontaneous breathing intensity in the patient.

2. The system of claim 1 , wherein generating the output related to the desired sedative status includes controlling a display device to display the desired sedative status that achieves the desired spontaneous breathing intensity in the patient, wherein the desired sedative status includes at least one of a desired sedative drug dosage or a desired sedation level.

3. The system of claim 1 , wherein the spontaneous breathing control module is further configured to control at least one drug delivery device, wherein the output related to the desired sedative status includes a desired sedative drug dosage to the at least one drug delivery device so as to achieve the desired sedative status and the desired spontaneous breathing intensity in the patient.

4. The system of claim 1 , wherein the sedation/breathing relationship is a fitting of at least a first point representing the first sedative status and the first spontaneous breathing intensity and a second point representing the second sedative status and the second spontaneous breathing intensity; and

wherein the desired sedative status is determined as a difference between a current sedative status and a sedative status corresponding to the desired spontaneous breathing intensity on the fitting.

5. The system of claim 1 , further comprising:

a gas analyzer that measures a CO 2 content in the expiration gas and determines a CO 2 concentration;

wherein the spontaneous breathing control module is further configured to:

determine a first preferred CO 2 level for the patient based on the CO 2 concentration at the first sedative status;

wherein determining the first spontaneous breathing intensity includes determining a breathing intensity at the first preferred CO 2 level;

determine a second preferred CO 2 level for the patient based on the CO 2 concentration at the second sedative status; and

wherein determining the second spontaneous breathing intensity includes determining a breathing intensity at the second preferred CO 2 level.

6. The system of claim 5 , wherein the first preferred CO 2 level is based on the CO 2 concentration measured over a first period of time at the first sedative status and the second preferred CO 2 level is determined based on the CO 2 concentration measured over a second period of time at the second sedative status.

7. The system of claim 6 , wherein the first preferred CO 2 level is determined based on a first average end tidal CO 2 concentration for the patient during the first period of time and the second preferred CO 2 level is determined based on a second average end tidal CO 2 concentration for the patient during the second period of time.

8. The system of claim 1 , wherein the spontaneous breathing control module is further configured to:

determine a respiratory trigger CO 2 concentration for the patient at the respective first or second sedative status; and

wherein the spontaneous breathing control module is further configured to determine a first preferred CO 2 level or a second preferred CO 2 level based on the respiratory trigger CO 2 concentration for the patient at the respective sedative status.

9. The system of claim 1 , wherein the first sedative status, the second sedative status, and the desired sedative status include respective sedation levels determined for the patient;

wherein the spontaneous breathing control module is further configured to determine a first sedation level for the patient based on physiological data measured from the patient receiving a first sedative drug dosage, and a second sedation level for the patient based on physiological data measured from the patient receiving a second sedative drug dosage; and

wherein the physiological data includes at least one of EMG data or EEG data.

10. The system of claim 1 , wherein spontaneous breathing intensity is determined based on at least one of a spontaneous breath rate and a spontaneous breath volume.

11. The system of claim 1 , wherein the first sedative status, the second sedative status, and the desired sedative status include respective drug dosages delivered to the patient; and

wherein each of a first sedative drug dosage, a second sedative drug dosage, and a desired sedative drug dosage include a dosage amount for each of one or more sedative drugs being delivered to the patient.

12. The system of claim 1 , wherein the first sedative status, the second sedative status, and the desired sedative status include respective drug dosages delivered to the patient; and

wherein each of a first sedative drug dosage, a second sedative drug dosage, and a desired sedative drug dosage include a target blood concentration value for each of one or more sedative drugs being delivered to the patient by target controlled infusion.

13. A method for controlling sedation and spontaneous breathing intensity of a patient, the method comprising:

receiving a first sedative status of the patient;

determining a first spontaneous breathing intensity at the first sedative status;

receiving a second sedative status of the patient;

determining a second spontaneous breathing intensity at the second sedative status;

defining a sedation/breathing relationship between spontaneous breathing intensity and sedative status for the patient based on the first sedative status and the first spontaneous breathing intensity and the second sedative status and the second spontaneous breathing intensity;

receiving a desired spontaneous breathing intensity;

determining a desired sedative status to achieve the desired spontaneous breathing intensity based on the sedation/breathing relationship; and

controlling one or more drug delivery devices based on the desired sedative status so as to achieve the desired spontaneous breathing intensity in the patient.

14. The method of claim 13 , wherein the first, second, and desired sedative statuses each include at least one of a sedation level determined based on physiological data measured from the patient or a sedative drug dosage being delivered to the patient.

15. The method of claim 14 , further comprising:

detecting a spontaneous inspiration of the patient; and

upon detecting the spontaneous inspiration, recording a current sedative drug dosage and/or a current sedation level and a current CO 2 concentration for the patient;

wherein the current sedation level is determined based on at least one of EMG data or EEG data measured from the patient.

16. The method of claim 15 , further comprising determining a respiratory trigger CO 2 concentration for the patient at the current sedative drug dosage and/or the current sedation level based on the current CO 2 concentration for the patient.

17. The method of claim 16 , further comprising:

controlling a ventilator system to decrease a ventilation support delivered to the patient to increase the patient's CO 2 concentration to at or above the respiratory trigger CO 2 concentration for the patient at a current sedative status to achieve the desired spontaneous intensity;

monitoring the patient's CO 2 concentration to determine whether is exceeds a maximum CO 2 limit; and

if the patient's CO 2 concentration exceeds the maximum CO 2 limit, controlling the ventilator system to increase the ventilation support delivered to the patient.

18. The method of claim 17 , further comprising:

receiving a predetermined exercise period for which the desired spontaneous breathing intensity should be maintained; and

upon determining that the patient has maintained the desired spontaneous breathing intensity for the predetermined exercise period, controlling the ventilator system to increase the ventilation support delivered or controlling the one or more drug delivery devices to increase the sedative status.

19. The method of claim 16 , further comprising:

determining a first preferred CO 2 level for the patient at a first sedative drug dosage;

determining a second preferred CO 2 level for the patient at a second sedative drug dosage; and

determining the preferred CO 2 level based further on the respiratory trigger CO 2 concentration for the patient at the respective sedative drug dosage.

20. The method of claim 13 , wherein the sedation/breathing relationship is defined by interpolating between at least a first point representing the first sedative status and the first spontaneous breathing intensity and a second point representing the second sedative status and the second spontaneous breathing intensity; and

wherein the desired sedative status is a sedative status corresponding to the desired spontaneous breathing intensity on the interpolation representing the sedation/breathing relationship.

21. The method of claim 13 , further comprising:

determining a first preferred CO 2 level for the patient at a first sedative drug dosage;

determining a second preferred CO 2 level for the patient at a second sedative drug dosage; and

wherein determining the first preferred CO 2 level includes determining a first average CO 2 concentration value over a first period of time at the first sedative status, and determining the second preferred CO 2 level includes determining a second average CO 2 concentration value over a second period of time at the second sedative status.

22. The method of claim 13 , wherein spontaneous breathing intensity is determined based on at least one of a spontaneous breath rate and a spontaneous breath volume.

23. The method of claim 13 , wherein the one or more drug delivery devices are automatically controlled based on the desired sedative status via a spontaneous breathing control module executable on a processor of a computing system controlling anesthesia delivery.