Use of GABA
A compound for use in the treatment of itch is provided, wherein the compound comprises the general formula (1a), general formula (1b) or general formula (1c). The compounds of the invention are positive allosteric α2 and/or α3 GABA A receptor modulators.
1. A method of treating itch in a subject comprising administering to the subject an amount of a compound selected from the group consisting of:
wherein the itch is not treatable with an antihistamine.
2. The method of claim 1 , wherein the itch is associated with kidney disease, liver disease, or treatment with opioids.
3. The method of claim 1 , wherein the compound is:
4. The method of claim 1 , wherein the amount is effective to treat the histamine-independent itch when administered at a dose of from about 0.1 mg/kg per day to about 10 mg/kg per day of a body weight of a dog when administered to the dog.
5. A pharmaceutical composition comprising a compound selected from the group consisting of:
wherein the compound is in the form of a suspension in a saline solution, and
wherein said pharmaceutical composition is formulated to provide a dose of at least 0.25 mg when administered to a subject.
6. The pharmaceutical composition of claim 5 , wherein the suspension comprises polysorbate 80.
7. The pharmaceutical composition of claim 5 , wherein the compound is: