Heterocyclic compounds as immunomodulators
Disclosed are compounds of Formula (I), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders such as cancer or infections.
1. A compound which is N-(3′-(8-chloro-6-((2-hydroxyethylamino)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-2,2′-dimethylbiphenyl-3-yl)-5-((2-hydroxyethylamino)methyl)picolinamide, or a pharmaceutically acceptable salt thereof.
2. A pharmaceutical composition comprising the compound of claim 1 , or a pharmaceutically acceptable salt thereof, and one or more pharmaceutically acceptable excipient or carrier.
3. The compound of claim 1 , wherein the compound is N-(3′-(8-chloro-6-((2-hydroxyethylamino)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-2,2′-dimethylbiphenyl-3-yl)-5-((2-hydroxyethylamino)methyl)picolinamide.
4. A pharmaceutical composition comprising the compound of claim 3 , and one or more pharmaceutically acceptable excipient or carrier.
5. A compound which is N-(2-chloro-3′-(8-chloro-6-((2-hydroxyethylamino)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-2′-methylbiphenyl-3-yl)-5-((2-hydroxyethylamino)methyl)picolinamide, or a pharmaceutically acceptable salt thereof.
6. A pharmaceutical composition comprising the compound of claim 5 , or a pharmaceutically acceptable salt thereof, and one or more pharmaceutically acceptable excipient or carrier.
7. The compound of claim 5 , wherein the compound is N-(2-chloro-3′-(8-chloro-6-((2-hydroxyethylamino)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-2′-methylbiphenyl-3-yl)-5-((2-hydroxyethylamino)methyl)picolinamide.
8. A pharmaceutical composition comprising the compound of claim 7 , and one or more pharmaceutically acceptable excipient or carrier.
9. A compound which is N-(2-chloro-3′-(8-cyano-6-((2-hydroxyethylamino)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-2′-methylbiphenyl-3-yl)-5-((2-hydroxyethylamino)methyl)picolinamide, or a pharmaceutically acceptable salt thereof.
10. A pharmaceutical composition comprising the compound of claim 9 , or a pharmaceutically acceptable salt thereof, and one or more pharmaceutically acceptable excipient or carrier.
11. The compound of claim 9 , wherein the compound is N-(2-chloro-3′-(8-cyano-6-((2-hydroxyethylamino)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-2′-methylbiphenyl-3-yl)-5-((2-hydroxyethylamino)methyl)picolinamide.
12. A pharmaceutical composition comprising the compound of claim 11 , and one or more pharmaceutically acceptable excipient or carrier.
13. A compound which is 2-((8-chloro-2-(2,2′-dimethyl-3′-(4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)biphenyl-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-6-yl)methylamino)ethanol, or a pharmaceutically acceptable salt thereof.
14. A pharmaceutical composition comprising the compound of claim 13 , or a pharmaceutically acceptable salt thereof, and one or more pharmaceutically acceptable excipient or carrier.
15. The compound of claim 13 , wherein the compound is 2-((8-chloro-2-(2,2′-dimethyl-3′-(4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)biphenyl-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-6-yl)methylamino)ethanol.
16. A pharmaceutical composition comprising the compound of claim 15 , and one or more pharmaceutically acceptable excipient or carrier.