Bio-active material composite, preparing method thereof and cosmetic composition containing the same
Provided is a composite containing bio-active material stably combined with a rare-earth hydroxide compound having a layered structure. The bio-active materials in the composite are preserved in terms of long-term stability at high temperature of 50° C. or above and the composite maintained in the neutral pH condition to minimize side effects like latent toxicity, irritations, etc. Further, the present invention is useful for a skin-whitening, anti-wrinkle, or anti-aging cosmetic composition containing the composite.
1. A composite containing a bio-active material combined with a rare-earth hydroxide compound, wherein the composite is represented by the following chemical formula 1:
[RE(OH) 3−x .y H 2 O].[A n ] x/n .[B] 2 [Chemical Formula 1]
wherein RE is at least one or more rare-earth element selected from the group consisting of yttrium (Y), gadolinium (Gd) and europium (Eu); A is an anion selected from the group consisting of F − , Cl − , ClO 3 − , ClO 4 − , Br − , BrO 3 − , IO 3 − , IO 4 − , I 3 − , OH − , CO 3 2− , HCO 3 − , NO 3 − , SO 4 2− , PO 4 3− , HPO 4 2 , and H 2 PO 4 − ; y is greater than zero, that is, 0<y; n is the charge number of the anion; x is greater than 0 and less than 3, that is, 0<x<3; B is a bio-active material; and z is greater than zero, that is, 0<z;
wherein the rare-earth hydroxide compound has a layered structure; and
wherein the bio-active material is at least one or more selected from the group consisting of vitamin C, vitamin A, salicylic acid, kojic acid, alpha-lipoic acid, ellagic acid, resveratrol, caffeine, docosahexaenoic acid, eicosapentaenoic acid, linoleic acid and glutathione.
2. The composite as claimed in claim 1 , wherein
the bio-active material comprises Vitamin C; and
the rare-earth hydroxide compound comprises yttrium hydroxide.
3. The composite as claimed in claim 1 , wherein
the bio-active material comprises Vitamin C; and
the rare-earth hydroxide compound comprises gadolinium/europium hydroxide.
4. The composite as claimed in claim 1 , wherein
the bio-active material comprises Vitamin A; and
the rare-earth hydroxide compound comprises yttrium hydroxide.
5. The composite as claimed in claim 1 , wherein
the bio-active material comprises salicylic acid; and
the rare-earth hydroxide compound comprises yttrium hydroxide.
6. The composite as claimed in claim 1 , wherein
the bio-active material comprises kojic acid; and
the rare-earth hydroxide compound comprises yttrium hydroxide.
7. The composite as claimed in claim 1 , wherein
the bio-active material comprises alpha-lipoic acid; and
the rare-earth hydroxide compound comprises yttrium hydroxide.
8. The composite as claimed in claim 1 , wherein
the bio-active material comprises ellagic acid; and
the rare-earth hydroxide compound comprises yttrium hydroxide.
9. The composite as claimed in claim 1 , wherein
the bio-active material comprises resveratrol; and
the rare-earth hydroxide compound comprises yttrium hydroxide.
10. The composite as claimed in claim 1 , wherein
the bio-active material comprises docosahexaenoic acid; and
the rare-earth hydroxide compound comprises yttrium hydroxide.
11. The composite as claimed in claim 1 , wherein
the bio-active material comprises eicosapentaenoic acid; and
the rare-earth hydroxide compound comprises yttrium hydroxide.
12. The composite as claimed in claim 1 , wherein
the bio-active material comprises linoleic acid; and
the rare-earth hydroxide compound comprises yttrium hydroxide.
13. The composite as claimed in claim 1 , wherein
the bio-active material comprises glutathione; and
the rare-earth hydroxide compound comprises yttrium hydroxide.
14. The composite as claimed in claim 1 , wherein RE is Y.