Pulsed radiofrequency ablation
Ablation systems and methods of the present disclosure are directed toward delivering pulsed radiofrequency (RF) energy to target tissue. The pulsations of the RF energy, combined with cooling at a surface of the target tissue, can advantageously promote local heat transfer in the target tissue to form lesions having dimensions larger than those that can be safely formed in tissue using non-pulsed RF energy under similar conditions.
1. A method comprising:
placing an expandable ablation electrode at an interface between tissue and blood in an anatomic structure of a patient, wherein the expandable ablation electrode is at a distal end portion of a catheter shaft and surrounds an irrigation port configured to direct irrigation fluid toward the interface, and wherein the irrigation port is coupled to the distal end portion of the catheter shaft at only a proximal end portion of the irrigation port;
delivering electrical energy to the ablation electrode at the interface during a period of lesion formation;
receiving, from a temperature sensor disposed at the interface, a signal indicative of temperature of the interface; and
delivering the irrigation fluid to the interface via the irrigation port during at least a portion of the period of lesion formation,
wherein—
the electrical energy delivered to the ablation electrode at the interface is changed between a first energy phase and a second energy phase during the period of lesion formation,
the electrical energy delivered in the first energy phase is greater than the electrical energy delivered in the second energy phase,
a combination of irrigation fluid and blood moves through the ablation electrode to cool the temperature of the interface during the period of lesion formation.
2. The method of claim 1 , wherein a rate of cooling of the interface by the combination of blood and irrigation fluid moving through the ablation electrode at the interface is greater than a rate of heating of the interface by the electrical energy during the second energy phase.
3. The method of claim 1 , wherein, during the period of lesion formation, the electrical energy is changed at least twice from the first energy phase to the second energy phase.
4. The method of claim 3 , wherein each of the second energy phases has a duration greater than 0 seconds and less than about 6 seconds.
5. The method of claim 3 , wherein each of the second energy phases has a predetermined duration.
6. The method of claim 3 , wherein each of the first energy phases has a predetermined duration.
7. The method of claim 1 , wherein a duration of one or more of the first energy phase and the second energy phase is based on the signal indicative of temperature of the interface.
8. The method of claim 1 , further comprising detecting a change in an electrical signal associated with the electrical energy delivered to the ablation electrode at the interface, wherein a duration of one or more of the first energy phase and the second energy phase is based on the detected change in the electrical signal.
9. The method of claim 1 , wherein a volumetric flow rate of the irrigation fluid is changed between a first volumetric flow rate and a second volumetric flow rate less than the first volumetric flow rate.
10. The method of claim 1 , wherein delivering the irrigation fluid to the interface includes mixing the irrigation fluid with blood moving through the ablation electrode at the interface.
11. A method comprising:
positioning an expandable ablation electrode at an interface between tissue and blood in an anatomic structure of a patient, wherein the expandable ablation electrode is carried b a catheter shaft and surrounds an irrigation port configured to direct irrigation fluid toward the interface, and wherein the irrigation port is coupled to a distal end region of the catheter shaft at only a proximal end region of the irrigation port;
delivering electrical energy to the ablation electrode at the interface;
receiving, from a temperature sensor disposed at the interface, a signal indicative of temperature of the interface; and
delivering the irrigation fluid to the interface via the irrigation port during at least a portion of the period of lesion formation,
wherein—
the electrical energy delivered to the ablation electrode at the interface is changed between a first energy phase and a second energy phase during the period of lesion formation,
the electrical energy in the first energy phase is greater than the electrical energy delivered in the second energy phase,
a combination of irrigation fluid and blood moves across the interface to cool the temperature of the interface during the period of lesion formation.
12. The method of claim 11 , wherein a rate of cooling of the interface by the combination of blood and irrigation fluid moving through the ablation electrode at the interface is greater than a rate of heating of the interface by the electrical energy during the second energy phase.
13. The method of claim 11 , wherein, during the period of lesion formation, the electrical energy is changed at least twice from the first energy phase to the second energy phase.
14. The method of claim 13 , wherein each of the second energy phases has a duration greater than 0 seconds and less than about 6 seconds.
15. The method of claim 13 , wherein each of the first energy phases and/or each of the second energy phases has a predetermined duration.
16. The method of claim 11 , wherein a duration of one or more of the first energy phase and the second energy phase is based on the signal indicative of temperature of the interface.
17. The method of claim 11 , further comprising detecting a change in an electrical signal associated with the electrical energy delivered to the ablation electrode at the interface, wherein a duration of one or more of the first energy phase and the second energy phase is based on the detected change in the electrical signal.
18. The method of claim 11 , wherein a volumetric flow rate of the irrigation fluid is changed between a first volumetric flow rate and a second volumetric flow rate less than the first volumetric flow rate.
19. A method comprising:
placing an expandable ablation electrode at an interface between tissue and blood in an anatomic structure of a patient, wherein the expandable ablation electrode is at a distal portion of a catheter shaft and surrounds an irrigation port configured to direct irrigation fluid toward the interface, and further wherein the irrigation port is connected to the distal portion of the catheter shaft at only a proximal end portion of the irritation port;
delivering electrical energy to the ablation electrode at the interface during a period of lesion formation;
receiving, from a temperature sensor disposed at the interface, a signal indicative of temperature of the interface; and
delivering the irrigation fluid to the interface via the irrigation port during at least a portion of the period of lesion formation,
wherein—
the electrical energy delivered to the ablation electrode at the interface is changed between a first energy phase and a second energy phase during the period of lesion formation,
the electrical energy delivered in the first energy phase is greater than the electrical energy delivered in the second energy phase,
a duration of the first energy phase is less than a duration of the second energy phase, and
a combination of irrigation fluid and blood moves through the ablation electrode to cool the temperature of the interface during the period of lesion formation.