IP Library › Granted Patent US 10,907,142
Granted Patent B2
US 10,907,142 · App. 16/268,989 · Granted Feb 2, 2021

Oligosaccharides comprising an aminooxy group and conjugates thereof

Inventors: Yunxiang Zhu (Bridgewater, NJ); Seng H. Cheng (Natick, MA); Canwen Jiang (Southborough, MA); Luis Z. Avila (Bridgewater, NJ)
Assignee: Genzyme Corporation
C12N9/96A61K38/47A61K47/549C07H15/04C12N9/16C12N9/2408C12Y301/04012C12Y302/0102C12Y302/01022C12Y302/01076
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Quick Facts
Patent No.
US 10,907,142
App. No.
16/268,989
Granted
Feb 2, 2021
Kind
B2
Abstract

The invention provides methods for the synthesis of oligosaccharides comprising an aminooxy group. The invention further provides oligosaccharides comprising an aminooxy group, methods for coupling oligosaccharides comprising an aminooxy group to glycoproteins, and oligosaccharide-protein conjugates. Also provided are methods of treating a lysosomal storage disorder in a mammal by administration of an oligosaccharide-protein conjugate.

Claims (1)

1. An oligosaccharide of Formula V:

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 6, 2020
From: ZHU, YUNXIANG; CHENG, SENG H.; JIANG, CANWEN; AVILA, LUIS Z.
To: GENZYME CORPORATION
Reel/Frame 053423/0010 →
Continuity (5)
Continuation 15280864 · Sep 29, 2016
Continuation 14272960 · May 8, 2014
Continuation 12523631
Provisional Application 60885471 · Jan 18, 2007
Related Publication 20200010825A1 · Jan 9, 2020
Cited By (4)
US 12,252,504 US 12,325,753 US 12,428,487 US 12,662,545