IP Library › Granted Patent US 10,933,251
Granted Patent B1
US 10,933,251 · App. 16/903,808 · Granted Mar 2, 2021

System for noninvasive pulsed magnetic induction heating of acupoints for the neurorehabilitation of stroke and brain injury, and for the prevention and treatment of dementia, age-related cognitive decline, and depression

Inventors: Jonathan M Borkum (Orono, ME); Mohsen Shahinpoor (Bangor, ME)
A61N1/406A61H39/06A61H39/086A61K41/0052A61M37/0069A61M2202/064A61N2/004A61N2/02
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Quick Facts
Patent No.
US 10,933,251
App. No.
16/903,808
Granted
Mar 2, 2021
Kind
B1
Abstract

Systems and devices for pulsed heating of the ST36 acupoint and/or other acupoint(s) by noninvasive transcutaneous magnetic induction heating towards (1) ameliorating cognitive impairment arising, for example, from head-injury, stroke, and neurodegenerative diseases such as Alzheimer's; (2) helping to prevent neurodegenerative diseases; (3) preventing and treating age-related cognitive decline; and (4) preventing and treating depression manifesting, for example, as Major Depressive Disorder, Dysthymic Disorder, or Adjustment Disorder with Depressed Mood.

Claims (22)

1. A method of treating a disorder comprising depositing a conductive substance on or into an acuregion, and periodically heating the acuregion using magnetic inductive heating of the conductive substance, wherein the acuregion is one or more of: ST36 (Zusanli), LI11 (Quchi), LI4 (Hegu), PC6 (Neiguan), and HT7 (Shenmen), wherein the conductive substance comprises one or more of: an electrically conductive gel, gold particles, conductive microparticles, a conductive powder, a network of a biocompatible conductor, graphene, a graphene net, or platinum.

2. The method of claim 1 , wherein periodically heating the acuregion comprises heating the acuregion at a rate in the range from 0.1 Hz to 100 Hz.

3. The method of claim 2 , wherein periodically heating the acuregion comprises heating the acuregion to a temperature in the range from 40 degrees C. to 50 degrees C.

4. The method of claim 2 , wherein periodically heating the acuregion comprises heating the acuregion at a rate in the range from 1.5 Hz to 2.5 Hz.

5. The method of claim 1 , wherein periodically heating the acuregion comprises heating the acuregion to a temperature in the range from 40 degrees C. to 50 degrees C.

6. The method of claim 1 , wherein depositing a conductive substance on or into an acuregion comprises using hollow acupuncture needles to deposit microparticles, powders, or a network of a biocompatible conductor on the acuregion.

7. The method of claim 6 , wherein the biocompatible conductor is graphene.

8. The method of claim 1 , wherein the disorder is a neurodegenerative disease.

9. The method of claim 8 , wherein treating a disorder comprises an improvement in depression, or improvement in, or a reduction in the rate of decline in, one or more of: (a) short-term memory for verbal material, (b) verbal fluency, (c) short-term memory for visuospatial material, (d) visuospatial ability, (e) span of attention, (f) abstract reasoning, and (g) cognitive processing speed.

10. The method of claim 1 , wherein the disorder is a vascular dementia.

11. The method of claim 10 , wherein treating a disorder comprises an improvement in depression, or improvement in, or a reduction in the rate of decline in, one or more of: (a) short-term memory for verbal material, (b) verbal fluency, (c) short-term memory for visuospatial material, (d) visuospatial ability, (e) span of attention, (f) abstract reasoning, (g) cognitive processing speed.

12. The method of claim 1 , wherein the disorder is a traumatic brain injury.

13. The method of claim 12 , wherein treating a disorder comprises an improvement in depression, or improvement in, or a reduction in the rate of decline in, one or more of: (a) short-term memory for verbal material, (b) verbal fluency, (c) short-term memory for visuospatial material, (d) visuospatial ability, (e) span of attention, (f) abstract reasoning, and (g) cognitive processing speed.

14. The method of claim 1 , wherein the disorder is an ischemic or hemorrhagic cerebrovascular accident.

15. The method of claim 14 , wherein treating a disorder comprises an improvement in depression, or improvement in, or a reduction in the rate of decline in, one or more of: (a) short-term memory for verbal material, (b) verbal fluency, (c) short-term memory for visuospatial material, (d) visuospatial ability, (e) span of attention, (f) abstract reasoning, and (g) cognitive processing speed.

16. The method of claim 1 , wherein the disorder is age-related cognitive decline.

17. The method of claim 16 , wherein treating a disorder comprises an improvement in depression, or improvement in, or a reduction in the rate of decline in, one or more of: (a) short-term memory for verbal material, (b) verbal fluency, (c) short-term memory for visuospatial material, (d) visuospatial ability, (e) span of attention, (f) abstract reasoning, and (g) cognitive processing speed.

18. The method of claim 1 , wherein the disorder is major depressive disorder, dysthymic disorder, adjustment disorder with depressed mood, or other depressive disorder.

19. A method of treating a disorder comprising depositing a conductive substance on or into an acuregion, and periodically heating the acuregion using magnetic inductive heating of the conductive substance, wherein the acuregion is one or more of: ST36 (Zusanli), LI11 (Quchi), LI4 (Hegu), PC6 (Neiguan), and HT7 (Shenmen),

wherein depositing a conductive substance on or into an acuregion comprises depositing a conductive gel on the acuregion.

20. A method of treating a disorder comprising depositing a conductive substance on or into an acuregion, and periodically heating the acuregion using magnetic inductive heating of the conductive substance, wherein the acuregion is one or more of: ST36 (Zusanli), LI11 (Quchi), LI4 (Hegu), PC6 (Neiguan), and HT7 (Shenmen), wherein depositing a conductive substance on or into an acuregion comprises using hollow acupuncture needles to deposit microparticles, powders, or a network of a biocompatible conductor on the acuregion,

wherein the biocompatible conductor is gold.

Cited By (1)
US 12,194,307