Controlled release core-shell particles and suspensions including the same
Provided is a composition including a dispersion medium including: an aqueous solution; a first active ingredient; a flavor agent; and a first type of polymer; and a dispersed phase including: a population of particles, each particle including: a core including: a second active ingredient a second type of polymer; and an aqueous solution; a shell, substantially surrounding the core, the shell including: a third type of polymer; a plurality of lipophilic carriers; and a third active ingredient; and a plurality of emulsifying agents.
1. A composition comprising:
a dispersion medium comprising:
an aqueous solution;
a first active ingredient, wherein the first active ingredient is a source of vitamin C and a single dose of the composition to be administered comprises an amount of 100 to 2000 mg of vitamin C; and
a first polymer, wherein the first polymer is a polysaccharide; and
a dispersed phase comprising:
a population of particles, each particle comprising:
a core comprising:
a second active ingredient, wherein the second active ingredient is a multivalent cation and a single dose of the composition to be administered comprises an amount of 5 to 40 mg of the multivalent cation;
a second polymer, wherein the second polymer is selected from the group consisting of alginic acid, sodium alginate, potassium alginate, calcium alginate, agar, guar gum, and xanthan gum; and
an aqueous solution;
a shell, substantially surrounding the core, the shell comprising:
a third polymer, wherein the third polymer is a water insoluble cellulose derivative;
a plurality of lipophilic carriers; and
a third active ingredient, wherein the third active ingredient is a source of cholecalciferol and a single dose of the composition to be administered comprises an amount of 5 to 30 mcg of cholecalciferol; and
a plurality of emulsifying agents,
wherein:
at least 50% by weight of the second active ingredient is released within 2 hours after consumption; and
at least 70% by weight of the third active ingredient is released within 2 hours after consumption.
2. The composition of claim 1 , wherein:
at least 60% by weight of the second active ingredient is not released within 30 minutes after consumption; and
at least 80% by weight of the third active ingredient is not released within 30 minutes after consumption.
3. The composition of claim 1 , wherein:
at least 50% by weight of the second active ingredient is released within 2 hours after consumption; and
at least 60% by weight of the second active ingredient is not released within 30 minutes after consumption.
4. The composition of claim 1 , wherein:
at least 30% by weight of the second active ingredient is not released within 4 hours after consumption.
5. The composition of claim 1 , wherein:
the source of cholecalciferol is obtained from lichen.
6. The composition of claim 1 , wherein:
a single dose of the composition is administered in a 1 to 2 ounces shot.
7. The composition of claim 1 , wherein:
the particle is part of the population of particles in the dispersion medium, and where the population has a Z-average diameter of about 0.5 to 5 μm.
8. The composition of claim 1 , wherein:
the second polymer is a chelating agent for the second active ingredient.
9. The composition of claim 1 , wherein:
the plurality of lipophilic carriers is selected from the group consisting of short-chain triglycerides, medium-chain triglycerides, long-chain triglycerides, medium-chain partial glycerides, polyoxyethylated fatty alcohols, polyethylene glycol, and vegetable oil.
10. The composition of claim 1 , the composition further comprising:
at least one preservative agent selected from the group consisting of sodium benzoate, sodium metabisulfite, potassium sorbate, sorbic acid, acetic acid, propionic acid, sulfites, nitrites, sodium sorbate, calcium sorbate, benzoic acid, and potassium benzonate.
11. The composition of claim 1 , wherein:
the plurality of emulsifying agents comprises at least two agents selected from the group consisting of an extract of Quillaja, lecithin, monoglycerides, polysorbate 80, polysorbate 20, Polyglycerol polyricinoleate, gum acacia, Xanthan gum, sorbitol, mannitol, glycerol, and sodium alginate.
12. The composition of claim 1 , wherein:
the core to the shell has a weight ratio in the range of 1:1.5 to 1:5.
13. The composition of claim 1 , wherein:
each particle of the population of particles is configured to begin release of the second and the third active ingredients at a pH below about 5.
14. The composition of claim 1 , the shell further comprising:
a wax selected from the group consisting of bees wax, carnauba wax, rice bran wax, camauba wax, and candelilla wax.
15. The composition of claim 1 , wherein:
the composition is shelf stable for at least 12 months at room temperature.