Emergency devices
Described herein are syringe devices comprising a syringe including a therapeutic dose of at least one drug to be used in a drug or substance overdose. Also provided herein are compositions and methods of treating opioid overdose using high dose naloxone.
1. A high dose naloxone composition including naloxone at a dose greater than or equal to about 5 mg configured for administration, wherein C max is between 15 ng/mL to 24 ng/mL and the administration is an injection.
2. The high dose naloxone composition of claim 1 , wherein the dose is greater than about 10 mg.
3. The high dose naloxone composition of claim 1 , including naloxone hydrochloride at a dose of 5 mg/0.5 mL.
4. The high dose naloxone composition of claim 3 , wherein the composition is configured for a single administration.
5. The high dose naloxone composition of claim 4 , wherein the administration is using an injection device.
6. The high dose naloxone composition of claim 1 , wherein the composition is aqueous.
7. The high dose naloxone composition of claim 1 , wherein the C max is 15.8 ng/mL.
8. The high dose naloxone composition of claim 1 , wherein the C max is 17.2 ng/mL.
9. A high dose naloxone composition including naloxone at a dose greater than about 5 mg configured for administration, wherein the AUC 0-0.04 h is between 0.01 h*ng/mL and 0.1 h*ng/mL and the administration is an injection.
10. The high dose naloxone composition of claim 9 , including naloxone hydrochloride at a dose of 5 mg/0.5 mL.
11. The high dose naloxone composition of claim 10 , wherein the composition is configured for a single administration.
12. The high dose naloxone composition of claim 11 , wherein the administration is using an injection device.
13. The high dose naloxone composition of claim 9 , wherein the AUC 0-0.04 h is 0.0129 h*ng/mL.
14. A high dose naloxone composition including naloxone at a dose greater than or equal to about 5 mg configured for administration, wherein the AUC 0-0.08 h is between 0.05 h*ng/mL to 0.2 h*ng/mL and the administration is an injection.
15. The high dose naloxone composition of claim 14 , including naloxone hydrochloride at a dose of 5 mg/0.5 mL.
16. The high dose naloxone composition of claim 15 , wherein the composition is configured for a single administration.
17. The high dose naloxone composition of claim 16 , wherein the administration is using an injection device.
18. The high dose naloxone composition of claim 14 , wherein the AUC 0-0.08 h is 0.0782 h*ng/mL.