Real-time x-ray dosimetry in intraoperative radiation therapy
Real-time X-ray dosimetry sensing in intraoperative radiation therapy (IORT). According to one aspect, a treatment head comprises at least one X-ray component configured to facilitate generation of therapeutic radiation in the X-ray wavelength range. A resilient balloon is disposed over the treatment head and configured for receiving therein a fluid to facilitate X-ray treatment of a tumor cavity. A plurality of X-ray sensing elements is disposed at a plurality of locations distributed on the interior or exterior of the resilient balloon and configured for sensing X-ray radiation emanating from the treatment head. A control system is provided that is responsive to data received from the X-ray sensing elements to determine a magnitude of X-ray radiation detected at each of the X-ray sensing elements.
1. A method for real-time X-ray dosimetry, comprising
disposing an X-ray treatment head within an inflatable balloon;
inflating the balloon;
using the X-ray treatment head to apply X-ray energy to a treatment surface external of the balloon;
detecting an X-ray dose delivered by the X-ray treatment head a plurality of sensing elements which are attached at a plurality of different locations on an inner surface of a peripheral wall of the balloon;
using an image capture device disposed within the balloon to capture an image of the inner surface and the plurality of sensing elements disposed on the inner surface;
using an electronic control system to assign a unique index value to each of the plurality of sensing elements contained in the image;
monitoring with the electronic control system each of the plurality of sensing elements with an assigned index value to obtain a visual indication associated with each of the plurality of sensing elements contained in the image; and
using the visual indication of each of the plurality of sensing elements to determine the X-ray dose delivered at the plurality of different locations.
2. The method according to claim 1 , wherein the plurality of different locations are respectively aligned with a plurality of points defined on the peripheral wall of the balloon where a plurality of orthogonal axes, centered on the X-ray treatment head, intersect the inner surface of the balloon, when the balloon is inflated.
3. The method according to claim 1 , wherein the plurality of different locations define an ovoid or spherical grid pattern on the inner surface of the balloon, when the balloon is inflated.
4. The method according to claim 1 , further comprising communicating image data from the image capture device to the electronic control system.
5. The method according to claim 4 wherein the image data is communicated from the image capture device to the electronic control system using at least one component selected from the group consisting of a conductive wire lead, an optical fiber, and a wireless data transceiver.
6. The method according to claim 1 , wherein the visual indication associated with each of the plurality of sensing elements is a fluorescence of the plurality of sensing elements when exposed to the X-ray energy.
7. The method according to claim 6 , wherein determining the X-ray dose delivered at the plurality of different locations is based on an intensity of fluorescence exhibited by each of the plurality of sensing elements.
8. The method according to claim 1 , wherein the visual indication associated with each of the plurality of sensing elements is a color change of the plurality of sensing elements, and wherein determining the X-ray dose delivered at the plurality of different locations is based on the color change exhibited by each of the plurality of sensing elements.
9. A system for real-time X-ray dosimetry, comprising
an inflatable balloon configured to receive within an interior thereof an X-ray treatment head from which X-rays are configured to be emitted;
a plurality of sensing elements attached to a peripheral wall which forms an inner surface of the balloon, the plurality of sensing elements responsive to X-ray energy;
an image capture device disposed within the balloon and configured to capture an image of the inner surface and the plurality of sensing elements disposed on the inner surface; and
an electronic control system configured to
assign each of the plurality of sensing elements contained in the image with a unique index value,
monitor each of the plurality of sensing elements having an assigned index value to obtain at least one visual indication associated with each of the plurality of sensing elements contained in the image, and
based on the at least one visual indication, determine an X-ray dose delivered at a plurality of different sensing locations respectively associated with the plurality of sensing elements.
10. The system according to claim 9 , wherein the plurality of different sensing locations are aligned with locations where a plurality of orthogonal axes having an origin at an approximate center of the balloon when inflated, intersect the inner surface of the balloon.
11. The system according to claim 9 , wherein the plurality of different sensing locations define an ovoid or spherical grid pattern on the inner surface of the balloon, when the balloon is inflated.
12. The system according to claim 9 , wherein the image capture device is configured to facilitate communication of image data from the image capture device to the electronic control system.
13. The system according to claim 12 , wherein the image data is communicated from the image capture device to the electronic control system using an information communication component selected from the group consisting of a conductive wire lead, an optical fiber, and a wireless data transceiver.
14. The system according to claim 9 , wherein the at least one visual indication associated with each of the plurality of sensing elements is a fluorescence or change color of the plurality of sensing elements when exposed to the X-ray energy.
15. The system according to claim 14 , wherein the electronic control system is configured to evaluate the fluorescence or color change as the basis for determining the X-ray dose delivered at each of the plurality of sensing elements.