Cooling device having a plurality of controllable cooling elements to provide a predetermined cooling profile

1. A cooling device for removing heat from subcutaneous lipid-rich cells of a subject having skin, the cooling device comprising:

a body;

a surface configured to face the subject's skin;

an inlet port configured to be coupled to a supply line;

an outlet port configured to be coupled to an output line; and

a cooling element positioned along a flow path between the inlet and outlet ports such that liquid from the inlet port flows through the cooling element, the cooling element including:

a thermoelectric cooler,

an interface member made of a metal or metal alloy and having one or more heat exchanging surfaces,

a serpentine shaped internal fluid chamber in thermal communication with the interface member and a plurality of fluid ports in fluid communication with opposite ends of the serpentine shaped internal fluid chamber, wherein the fluid ports are configured to allow the liquid to circulate in one direction through the serpentine shaped internal fluid chamber, wherein the liquid in communication with the serpentine shaped internal fluid chamber is circulated through a device that chills the liquid, wherein adjacent sections of the serpentine shaped internal fluid chamber are defined by a cover containing an o-ring, wherein the cooling element is attached to the body such that the one or more heat exchanging surfaces of the interface member form at least a temperature controlled portion of the surface configured to face the subject's skin and the thermoelectric cooler is within the body, and

a sensing element proximate to the interface member; and

wherein the cooling device is configured to reduce a temperature of a target region such that the subcutaneous lipid-rich cells in the target region are reduced while non-lipid-rich cells proximate to the one or more heat exchanging surfaces are not significantly affected.

2. The cooling device of claim 1 , wherein the cooling element is configured to reduce the temperature of the subcutaneous lipid-rich cells in the target region to between −20° C. and 5° C.

3. The cooling device of claim 2 , wherein the cooling element is controlled according to a predetermined time-varying temperature profile.

4. The cooling device of claim 3 , further comprising a processing unit programmed to cause the cooling element to operate to cool the subcutaneous lipid-rich cells in the target region to a sufficiently low temperature so as to selectively disrupt the subcutaneous lipid-rich cells.

5. The cooling device of claim 4 , wherein the predetermined time-varying temperature profile comprises changing the temperature to be above about 30° C. and then lowering the temperature to about 0° C. or below.

6. A cooling device for removing heat from subcutaneous lipid-rich cells of a subject having skin, the cooling device comprising:

a body;

a surface configured to face the subject's skin;

an inlet port configured to be coupled to a supply line;

an outlet port configured to be coupled to an output line;

a cooling element positioned along a flow path between the inlet and outlet ports such that liquid from the inlet port flows through the cooling element, wherein the cooling element is configured to reduce a temperature of the subcutaneous lipid-rich cells in the region to between −20° C. and 5° C. according to a predetermined time-varying temperature profile, the cooling element including:

a thermoelectric cooler,

an interface member,

an internal fluid chamber in thermal communication with the interface member,

a plurality of fluid ports in fluid communication with the internal fluid chamber, wherein the fluid ports are configured to allow liquid circulation through the internal fluid chamber, wherein the interface member is made of a metal or metal alloy and has at least one heat exchanging surface, and wherein the cooling element is coupled to the body such that the at least one heat exchanging surface forms at least a portion of the surface configured to face the subject's skin and the thermoelectric cooler is within the body,

a processing unit programmed to

store predetermined time-varying cooling profiles for different target sites, at least one of the predetermined time-varying cooling profiles has at least three segments each including a predetermined period of time and associated setpoint temperature for a target site, and

control the cooling device according to the predetermined time-varying cooling profile to cause the cooling elements to operate to sequentially

cool the subcutaneous lipid-rich cells of the subject to reduce a temperature of the subcutaneous lipid-rich cells in the region to between −20° C. and 5° C. so as to selectively disrupt the subcutaneous lipid-rich cells, and

heat the subject's cooled tissue, and

a sensing element proximate to the interface member; and

wherein the cooling device is configured to reduce the temperature of a target region such that lipid-rich cells in the target region are reduced while non-lipid-rich cells proximate to the heat exchanging surfaces are not significantly affected.

7. The device of claim 6 , wherein the predetermined time-varying temperature profile comprises changing the temperature to above about 30° C. and then cooling to a temperature below 0° C.

8. The device of claim 6 , wherein the supply line and/or the output line is a hose.

9. The device of claim 6 , wherein the cooling element includes an additional thermoelectric cooler, wherein the internal fluid chamber is configured to circulate the liquid such that the liquid absorbs heat from each of the thermoelectric coolers.