Cochelates using phosphatidylserine/anionic surfactant/calcium chloride

1. A cochleate consisting essentially of 0.1 to 20% by weight of phosphatidylserine, 0.001 to 5% by weight of anionic surfactant, 0.0001 to 2% by weight of calcium chloride, 0.0005 to 50% by weight of an active ingredient and 30 to 96% by weight of water,

wherein the anionic surfactant is selected from the group consisting of sodium stearoyl glutamate, disodium stearoyl glutamate, sodium lauryl glucose carboxylate and sodium methyl cocoyl taurate, and wherein the cochleate does not contain a lipid other than phosphatidylserine.

2. The cochleate according to claim 1 , which consists essentially of 0.5 to 18% by weight of phosphatidylserine, 0.01 to 3% by weight of anionic surfactant, 0.0005 to 1.8% by weight of calcium chloride, 0.001 to 45% by weight of the active ingredient and 40 to 95% by weight of water.

3. The cochleate according to claim 2 , which consists essentially of 1 to 15% by weight of phosphatidylserine, 0.1 to 2% by weight of anionic surfactant, 0.001 to 1.5% by weight of calcium chloride, 0.002 to 40% by weight of the active ingredient and 50 to 94% by weight of water.

4. The cochleate according to claim 1 , wherein the anionic surfactant is sodium stearoyl glutamate.

5. The cochleate according to claim 1 , wherein the active ingredient is one or more selected from the group consisting of a moisturizer, a whitening agent, an anti-wrinkle agent, a UV blocking agent, a hair growth promoter, vitamin or a derivative thereof, amino acid or peptide, an anti-inflammatory agent, an acne therapeutic agent, a microbicide, female hormone, a keratolytic agent and a natural product.

6. The cochleate according to claim 5 , wherein the moisturizer is one or more selected from the group consisting of creatine, polyglutamic acid, sodium lactate, hydroproline, 2-pyrrolidone-5-carboxyclic acid sodium salt, hyaluronic acid, sodium hyaluronate, ceramide, phytosteryl, cholesterol, sitosterol, pullulan and proteoglycan.

7. The cochleate according to claim 5 , wherein the whitening agent is one or more selected from the group consisting of arbutin and a derivative thereof, kojic acid, bisabolol, niacinamide, vitamin C and a derivative thereof, placenta and allantoin.

8. The cochleate according to claim 5 , wherein the anti-wrinkle agent is one or more selected from the group consisting of retinol, a retinol derivative, adenosine, licorice extract, red ginseng extract and ginseng extract.

9. The cochleate according to claim 5 , wherein the UV blocking agent is one or more selected from the group consisting of benzophenone derivative, para-aminobenzoic acid derivative, methoxycinnamic acid derivative and salicylic acid derivative.

10. The cochleate according to claim 5 , wherein the hair growth promoter is a blood circulation promoter or a hair follicle stimulant.

11. The cochleate according to claim 10 , wherein the blood circulation promoter is one or more selected from the group consisting of an extract of Swertia japonica Makino, cepharanthin, vitamin E and a derivative thereof, and gamma-oryzanol.

12. The cochleate according to claim 10 , wherein the hair follicle stimulant is one or more selected from the group consisting of capsicum tincture, ginger tincture, cantharides tincture and nicotinic acid benzyl ester.

13. The cochleate according to claim 5 , wherein the vitamin or a derivative thereof is one or more selected from the group consisting of vitamin A and a derivative thereof, vitamin B1, vitamin B2, vitamin B6, vitamin E and derivatives thereof, vitamin D, vitamin H, vitamin K, pantothenic acid and derivatives thereof, biotin, panthenol, coenzyme Q 10 and idebenone.

14. The cochleate according to claim 5 , wherein the amino acid or peptide is one or more selected from the group consisting of cysteine, methionine, serine, lysine, tryptophan, amino acid extract, epidermal growth factor (EGF), insulin-like growth factor (IGF), fibroblast growth factor (FGF), copper tripeptide-1, tripeptide-29, tripeptide-1, acetyl hexapeptide-8, nicotinoyl tripeptide-35, hexapeptide-12, hexapeptide-9, palmitoyl pentapeptide-4, palmitoyl tetrapeptide-7, palmitoyl tripeptide-29, palmitoyl tripeptide-1, nonapeptide-7, tripeptide-10 citrulline, sh-polypeptide-15, palmitoyl tripeptide-5, diaminopropionoyl tripeptide-33 and r-spider polypeptide-1.

15. The cochleate according to claim 5 , wherein the anti-inflammatory agent is one or more selected from the group consisting of beta-glycyrrhetinic acid, glycyrrhetinic acid derivative, aminocaproic acid, hydrocortisone, β-glucan and licorice.

16. The cochleate according to claim 5 , wherein the acne therapeutic agent is one or more selected from the group consisting of estradiol, estrogen, ethinyl estradiol, triclosan and azelaic acid.

17. The cochleate according to claim 5 , wherein the microbicide is one or more selected from the group consisting of benzalkonium chloride, benzethonium chloride and halocalban.

18. The cochleate according to claim 5 , wherein the female hormone is one or more selected from the group consisting of estradiol, ethinyl estradiol and isoflavone.

19. The cochleate according to claim 5 , wherein the keratolytic agent is one or more selected from the group consisting of sulfur, salicylic acid, alpha-hydroxy acid (AHA), beta-hydroxy acid (BHA), and resorcin.

20. The cochleate according to claim 5 , wherein the natural product is one or more selected from the group consisting of an extract of Japanese witch-hazel, an extract of Lamium album var. barbatum , an extract of Hedyotis diffusa , an extract of Rheum palmatum , an extract of licorice, an extract of aloe, an extract of chamomile, an extract of rose hip, an extract of horse chestnut, an extract of ginseng , an extract of Luffa aegyptiaca , an extract of cucumber, an extract of laver, an extract of sea mustard, an extract of Dioscorea batatas , an extract of snail, an extract of fruit of Dioscorea polystachya , hinokitiol and beta-carotene.