Crystalline solid forms of salts of N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N′-(4-fluorophenyl) cyclopropane-1, 1-dicarboxamide, processes for making, and methods of use
The invention relates to novel crystalline solid forms of salts of the chemical compound N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N′-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, and solvates thereof, including hydrates, that are useful for the treatment of cancer. Also disclosed are pharmaceutical compositions comprising the crystalline solid forms and processes for making the crystalline solid forms, as well as methods of using them for the treatment of cancer, particularly renal cell carcinoma (RCC) and medullary thyroid cancer (MTC).
1. Crystalline solid salts of N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N′-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide (Compound 1), wherein the salts are selected from the group consisting of:
N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]pheny}-N′-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide (Compound 1) ⋅ pyruvate;
N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N′-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide (Compound 1) ⋅ glutarate; and
N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N′-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide (Compound 1) ⋅ isethionate monohydrate.
2. Crystalline solid N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N′-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide (Compound 1) ⋅ pyruvate of claim 1 , characterized as Form 14, wherein the crystalline solid comprises Compound 1 and pyruvate in a 1:1 molar ratio.
3. Crystalline solid Compound 1 ⋅ pyruvate, characterized as Form 14, according to claim 2 , wherein the Form 14 is characterized by one or more peaks in an XRPD pattern selected from the group consisting of 7.84, 8.81, 11.58, 15.67, 16.30, 16.55, 17.67, 17.92, 18.00, 18.20, 18.62, 19.66, 20.54, 20.75, 23.84, 26.35, and 26.42 degrees on a 2-theta scale.
4. Crystalline solid Compound 1 ⋅ pyruvate, characterized as Form 14, according to claim 2 or claim 3 , wherein the Form 14 is characterized by the peaks at 8.81, 11.58, 17.67, 18.00, 23.84, and 26.35 degrees on a 2-theta scale in an X-ray powder diffraction spectrum.
5. Crystalline solid Compound 1 ⋅ pyruvate, characterized as Form 14, according to any one of claims 2 - 4 , wherein the Form 14 is characterized by an XRPD pattern according to FIG. 5 .
6. Crystalline solid N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N′-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide (Compound 1) ⋅ glutarate of claim 1 , characterized as Form 20, wherein the crystalline solid comprises Compound 1 and glutarate in a 1:1 molar ratio.
7. Crystalline solid Compound 1 ⋅ glutarate, characterized as Form 20, according to claim 6 , wherein the Form 20 is characterized by one or more peaks in an X-ray powder diffraction spectrum selected from the group consisting of 8.06, 11.77, 19.97, 20.21, 22.27, 23.11, 23.17, 25.81, 25.87, 26.00, and 26.06 degrees on a 2-theta scale.
8. Crystalline solid Compound 1 ⋅ glutarate, characterized as Form 20, according to claim 6 or claim 7 , wherein the Form 20 is characterized by the peaks at 8.06, 11.77, 20.21, 22.27, 23.11, 25.81, 25.87, and 26.00 degrees on a 2-theta scale in an X-ray powder diffraction spectrum.
9. Crystalline solid N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N′-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide (Compound 1) ⋅ isethionate monohydrate of claim 1 , characterized as Form 27, wherein the crystalline solid comprises Compound 1 and isethionate in a 1:1 molar ratio.
10. Crystalline solid Compound 1 ⋅ isethionate monohydrate, characterized as Form 27, according to claim 9 , wherein the Form 27 is characterized by one or more peaks in an X-ray powder diffraction spectrum selected from the group consisting of 6.56, 12.39, 12.59, 13.14, 16.57, 17.55, 21.68, 23.66, 24.33, 26.09, 26.53, 26.69, and 27.40 degrees on a 2-theta scale.
11. Crystalline solid Compound 1 ⋅ isethionate monohydrate, characterized as Form 27, according to claim 9 or claim 10 , wherein the Form 27 is characterized by the peaks at 12.39, 12.59, 17.55, 21.68, 23.66, 24.33, and 26.09 degrees on a 2-theta scale in an X-ray powder diffraction spectrum.
12. Crystalline solid Compound 1 ⋅ isethionate monohydrate, characterized as Form 27, according to any one of claims 9 - 11 , wherein the Form 27 is characterized by an XRPD pattern according to FIG. 9 .
13. A pharmaceutical composition comprising a therapeutically effective amount of a substantially pure crystalline solid form of a salt of Compound 1 or a mixture of crystalline solid forms of a salt of Compound 1 as recited by claim land a pharmaceutically acceptable carrier.
14. A method of treating cancer comprising administering to a subject a therapeutically effective amount of a crystalline solid form of a salt of Compound 1 as recited by claim 1 .
15. A method of treating cancer comprising administering to a subject a pharmaceutical composition as recited by claim 13 .
16. The method of claim 14 or 15 , wherein the cancer is selected from thyroid cancer, stomach cancer, esophageal carcinoma, kidney cancer, liver cancer, ovarian carcinoma, cervical carcinoma, bladder cancer, large bowel cancer, small bowel cancer, brain cancer, lung cancer, bone cancer, prostate carcinoma, pancreatic carcinoma, skin cancer, bone cancer, lymphoma, solid tumors, Hodgkin's disease, or non-Hodgkin's lymphoma.