IP Library › Granted Patent US 11,279,916
Granted Patent B2
US 11,279,916 · App. 16/090,535 · Granted Mar 22, 2022

Enzyme and application thereof

Inventors: Ping Xu (Shanghai, CN); Hongzhi Tang (Shanghai, CN); Kunzhi Zhang (Shanghai, CN); Geng Wu (Shanghai, CN); Fei Tao (Shanghai, CN)
Assignee: Shanghai Jiao Tong University
C12N9/0012A61K38/44A61P25/34C12Y105/99004
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Quick Facts
Patent No.
US 11,279,916
App. No.
16/090,535
Granted
Mar 22, 2022
Kind
B2
Abstract

Provides an artificial enzyme obtained by improving upon a sequence of a natural nicotine dehydrogenase, wherein the improvement comprises replacing at least one amino acid hindering product release with an amino acid with smaller side chains, thereby improving a catalytic rate.

Claims (2)

1. An enzyme, the enzyme having the activity for catalyzing the conversion reaction from compound I to compound II as shown by the following formula:

wherein the enzyme has an amino acid sequence as shown in SEQ ID NO:2, or as shown in SEQ ID NO:8, or as shown in SEQ ID NO:9, or as shown in SEQ ID NO:10, or as shown in SEQ ID NO:11.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 7, 2019
From: XU, PING; TANG, HONGZHI; ZHANG, KUNZHI; WU, GENG; TAO, FEI
To: SHANGHAI JIAO TONG UNIVERSITY
Reel/Frame 048270/0921 →
Priority Claims (1)
CN 201610205619.5 · Apr 1, 2016 · national
Continuity (1)
Related Publication 20190153403A1 · May 23, 2019
Cited By (2)
US 12,318,433 US 12,516,299