Substituted piperazines as KRAS G12C inhibitors
Provided herein are KRAS G12C inhibitors, such as composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
1. A compound selected from the group consisting of:
or a stereoisomer thereof, or a pharmaceutically acceptable salt of said compound or said stereoisomer.
2. A pharmaceutical composition comprising the compound of claim 1 , or a stereoisomer thereof, or a pharmaceutically acceptable salt of said compound or said stereoisomer, and a pharmaceutically acceptable excipient.
3. A compound selected from the group consisting of:
or a stereoisomer thereof, or a pharmaceutically acceptable salt of said compound or said stereoisomer.
4. A pharmaceutical composition comprising the compound of claim 3 , or a stereoisomer thereof, or a pharmaceutically acceptable salt of said compound or said stereoisomer, and a pharmaceutically acceptable excipient.