Formulation including a combination of beta-endorphin and adrenocorticotropic hormone
The present specification provides compositions of β-endorphin and adrenocorticotropic hormone (ACTH). These compositions are useful in methods of treating disease.
1. A method of treating an inflammatory, autoimmune, neurologic disease or disorder comprising administering a clinically effective amount of adrenocorticotropic hormone (ACTH) and β-endorphin, to a person in need thereof, wherein the person in need thereof has multiple sclerosis.
2. The method of claim 1 , wherein treating comprises resolving an acute exacerbation of the disease.
3. The method of claim 1 , wherein treating comprises maintenance therapy, whereby incidences or severity of exacerbations of the disease is reduced.
4. The method of claim 3 , wherein the disease is relapsing-remitting multiple sclerosis and the incidence or severity of relapses is reduced.
5. The method of claim 1 comprising administering 40-120 units of ACTH.
6. The method of claim 5 , wherein the mass ratio of ACTH:β-endorphin is 2:1.
7. The method of claim 1 comprising administering 0.8-1.2 mg of ACTH.
8. The method of claim 7 , wherein the mass ratio of ACTH:β-endorphin is 2:1.