Scaffold wound dressing
View Patent ↗Disclosed is an external wound dressing formed of a bioprotein scaffolding that may include a pressure-sensitive adhesive impregnated in the bioprotein scaffolding. A method of wound treatment can include adhering an external wound dressing formed of a bioprotein scaffolding to an external injury site. Another method can include applying an adhesive to the skin of a patient, placing an external wound dressing formed of a bioprotein scaffolding over an injury site on the skin of the patient, and applying a sealing adhesive on top of the bioprotein scaffolding. Yet another method can include applying an adhesive to the skin of a patient, placing an external wound dressing formed of a bioprotein scaffolding over an injury site on the skin of the patient that has not been stitched, and applying a sealing adhesive on top of the bioprotein scaffolding.
1. A method comprising:
adhering an external wound dressing formed of an animal-derived bioprotein scaffolding to skin of a patient, over a surgical incision, and to prevent incisional separation, wherein the animal-derived bioprotein scaffolding is formed of bioprotein fibers woven together to form regular or semi-regular boundaries of interstitial spaces.
2. The method of claim 1 , wherein the animal-derived bioprotein scaffolding comprises an insect-derived bioprotein.
3. The method of claim 2 , wherein the animal-derived bioprotein scaffolding comprises a silk bioprotein.
4. The method of claim 3 , wherein the silk bioprotein is obtained from Bombyx mori silkworms.
5. The method of claim 4 , wherein the silk bioprotein has a reduced amount of sericin relative to the amount of sericin naturally present in the silk bioprotein.
6. The method of claim 1 , wherein the adhering comprises application of an adhesive to a patient followed by application of the animal-derived bioprotein scaffolding.
7. The method of claim 1 , wherein an adhesive is integrated with the animal-derived bioprotein scaffolding and the adhering comprises application of the animal-derived bioprotein scaffolding with the integrated adhesive.
8. The method of claim 7 , wherein the adhesive is included within the interstitial spaces.
9. The method of claim 7 , wherein the adhesive is a pressure-sensitive adhesive.
10. The method of claim 1 , further comprising applying a sealing adhesive on top of the animal-derived bioprotein scaffolding.
11. The method of claim 10 , wherein the sealing adhesive comprises cyanoacrylate.
12. The method of claim 1 , wherein the surgical incision has not been stitched.
13. The method of claim 1 , wherein the bioprotein fibers comprise multiple silk protein filaments combined by helical twisting to form a multi-filament bioprotein fiber.
14. The method of claim 1 , wherein the boundaries of the interstitial spaces have an area or dimension that varies by no more than 5%.
15. The method of claim 1 , wherein the boundaries of the interstitial spaces have an area or dimension that varies by no more than 20%.
16. A method comprising:
adhering an external wound dressing formed of an animal-derived bioprotein scaffolding to skin of a patient, over a surgical incision, and to prevent incisional separation, wherein the animal-derived bioprotein scaffolding is formed of bioprotein fibers woven together to form boundaries of interstitial spaces that repeat to form a scaffolding structure.
17. The method of claim 16 , wherein the adhering comprises application of an adhesive to a patient followed by application of the animal-derived bioprotein scaffolding.
18. The method of claim 16 , wherein an adhesive is integrated with the animal-derived bioprotein scaffolding and the adhering comprises application of the animal-derived bioprotein scaffolding with the integrated adhesive.
19. The method of claim 18 , wherein the adhesive is a pressure-sensitive adhesive.
20. The method of claim 16 , further comprising applying a sealing adhesive on top of the animal-derived bioprotein scaffolding.
21. The method of claim 20 , wherein the sealing adhesive comprises cyanoacrylate.