Engineered IL-2 Fc fusion proteins
The present invention provides IL-2-Fc fusion proteins comprising IL-2 variants.
1. An IL-2-Fc fusion protein comprising:
a) a first monomer having the sequence of SEQ ID NO:297:
b) a second monomer having the sequence of SEQ ID NO:298.
2. A nucleic acid composition comprising:
a) a first nucleic acid encoding the first monomer of claim 1 ; and
b) a second nucleic acid encoding the second monomer of claim 1 , respectively.
3. An expression vector composition comprising:
a) a first expression vector comprising the first nucleic acid of claim 2 ; and
b) a second expression vector comprising the second nucleic acid of claim 2 .
4. A host cell comprising the expression vector composition according to claim 3 .
5. A method of making an IL-2-Fc fusion protein comprising culturing the host cell of claim 4 under conditions wherein the IL-2-Fc fusion protein is produced and recovering the IL-2-Fc fusion protein.