Medicament for preventing and/or treating dry eye
A compound useful for preventing or treating dry eye and a medicament for preventing and/or treating dry eye comprising the same which does not substantially impact on the intraocular pressure are provided. A method of preventing and/or treating dry eye in a subject in need thereof, comprising administering a therapeutically effective amount of olodaterol or a salt thereof to the subject is also provided.
1. A method of preventing and/or treating dry eye in a subject in need thereof, comprising administering a therapeutically effective amount of olodaterol or a salt thereof to the subject.
2. The method according to claim 1 , wherein the dry eye accompanies corneal and conjunctival epithelium disorder caused by at least one selected from the group consisting of superficial punctate keratopathy, corneal epithelium defect, corneal erosion, corneal ulcer, conjunctival epithelium defect, keratoconjunctivitis sicca, superior limbic keratoconjunctivitis, filamentary keratoconjunctivitis, non-infectious keratitis, and non-infectious conjunctivitis.
3. The method according to claim 1 , wherein the dry eye is a disease caused by at least one selected from the group consisting of tear film instability, lacrimal hyposecretion, xerophthalmia, tear deficiency, keratoconjunctivitis sicca, lacrimal gland dysfunction, meibomian gland dysfunction, VDT (Visual Display Terminal) operation, use of contact lenses, tear abnormalities, and keratoconjunctivitis.
4. The method according to claim 1 , wherein the olodaterol or a salt thereof is administered in a concentration of 0.1% (w/v) or less.
5. The method according to claim 1 , wherein the olodaterol or a salt thereof is administered in a concentration of 0.01% (w/v) or less.
6. The method according to claim 1 , wherein the olodaterol or a salt thereof is administered in a concentration of 0.00001 to 0.01% (w/v).
7. The method according to claim 1 , wherein the olodaterol or a salt thereof is administered in a concentration of 0.00001 to 0.005% (w/v).
8. The method according to claim 1 , wherein the olodaterol or a salt thereof is administered in a concentration of 0.00001 to 0.001% (w/v).
9. The method according to claim 1 , wherein the olodaterol or a salt thereof is administered in the form of an eye drop.
10. The method according to claim 1 , wherein administering the olodaterol or a salt thereof does not substantially increase and/or reduce intraocular pressure.
11. The method according to claim 1 , wherein the olodaterol or a salt thereof is olodaterol hydrochloride.
12. A method of stabilizing tear film in a subject in need thereof, comprising administering a therapeutically effective amount of olodaterol or a salt thereof to the subject.
13. A method of enhancing lacrimal secretion and/or increasing tear volumes in a subject in need thereof, comprising administering a therapeutically effective amount of olodaterol or a salt thereof to the subject.
14. A method of preventing and/or treating dry eye in a subject in need thereof, comprising administering a therapeutically effective amount of olodaterol a salt thereof to the subject,
wherein the olodaterol or a salt thereof is administered in a concentration of 0.00001 to 0.01% (w/v),
wherein the olodaterol or a salt thereof stabilizes tear film and/or enhances lacrimal secretion and/or increases tear volumes, and
wherein administering the olodaterol or a salt thereof does not substantially increase and/or reduce intraocular pressure.