Method of treating idiopathic pulmonary fibrosis and kidney fibrosis
Provided herein are compounds, compositions, and methods of identifying compounds that neutralize the ability of the cannabinoid receptor type-1 (CB1) agonist 2-arachidonylglycerol (2-AG) in complex with its obligate binding partner adipocyte lipid binding protein (aP2) from agonizing CB1 signaling in peripheral tissues. Further provided herein are methods of treating a disorder associated with dysregulated or abnormal hepatic de novo lipogenesis and/or hepatic selective insulin resistance by inhibiting cannabinoid receptor type-1 (CB1) agonist 2-arachidonylglycerol (2-AG) in complex with its obligate binding partner adipocyte lipid binding protein (aP2) from binding and agonizing CB1.
1. A method of neutralizing 2-arachidonylglycerol (2-AG)/adipocyte lipid binding protein (aP2) agonism of cannabinoid receptor type-1 (CB1) for treating a subject having fibrosis comprising administering to the subject an antibody, antibody fragment, or antigen binding agent that neutralizes the ability of 2-AG/aP2 to bind to CB1, wherein the compound does not directly bind to CB1, and wherein the fibrosis is idiopathic pulmonary fibrosis or kidney fibrosis.
2. The method of claim 1 , wherein the subject is human.
3. The method of claim 2 , wherein the subject has kidney fibrosis.
4. The method of claim 2 , wherein the subject has idiopathic pulmonary fibrosis.
5. The method of claim 2 , wherein the compound is a monoclonal antibody.