Triggering sequence
A therapeutic substance delivery device includes a fluid path having a reservoir needle, a body needle, a body needle injection mechanism, and a pumping assembly (a) configured to pump the substance from the reservoir to the subject, (b) shaped to define a pump chamber, and (c) including a plunger disposed within the pump chamber. The plunger moves back and forth through a plurality of discrete motion phases. A first motion phase of the plunger actuates a first operation from a group of operations including (a) driving the reservoir needle to penetrate the reservoir, (b) advancing the body needle into the body of the subject, (c) withdrawing the substance from the reservoir, (d) pumping the substance into the subject, and (e) retracting the body needle. A second motion phase of the plunger actuates a second operation from the group of operations. Other applications are also described.
1. Apparatus for delivering a therapeutic substance to a subject, the apparatus comprising:
a therapeutic substance delivery device configured to be engaged with a therapeutic substance reservoir, the therapeutic substance delivery device comprising:
a fluid path comprising a reservoir needle that is configured to penetrate the therapeutic substance reservoir;
a body needle;
a body needle injection mechanism configured to (a) advance the body needle into a body of the subject and (b) retract the body needle from the body of the subject; and
an electromechanical pumping assembly (a) configured to pump the therapeutic substance from the therapeutic substance reservoir to the subject, (b) shaped to define a pump chamber, and (c) comprising a plunger disposed within the pump chamber, the plunger configured to move back and forth through a plurality of discrete motion phases,
wherein a first one of the motion phases of the plunger actuates a first operation selected from the group consisting of: driving the reservoir needle to penetrate the therapeutic substance reservoir, advancing the body needle into the body of the subject, withdrawing the therapeutic substance from the therapeutic substance reservoir, pumping the therapeutic substance into the subject, and retracting the body needle,
wherein a second one of the motion phases of the plunger actuates a second operation selected from the group, and
wherein a third one of the motion phases of the plunger actuates a third operation selected from the group.
2. The apparatus according to claim 1 , wherein the electromechanical pumping assembly is arranged such that the first one of the motion phases actuates a single operation selected from the group, and the second one of the motion phases actuates two operations selected from the group.
3. The apparatus according to claim 1 , wherein the electromechanical pumping assembly is arranged such that one of the motion phases of the plunger actuates the operation of advancing the body needle into the body of the subject and also actuates the operation of withdrawing the therapeutic substance from the therapeutic substance reservoir.
4. The apparatus according to claim 1 , wherein the first motion phase of the plunger is in a first direction, and wherein the second motion phase of the plunger is in a second direction.
5. The apparatus according to claim 4 , wherein:
the third motion phase of the plunger is in the first direction, and
the electromechanical pumping assembly is arranged such that (a) the first motion phase is before the second motion phase, and (b) the second motion phase is before the third motion phase.
6. The apparatus according to claim 5 , wherein:
a fourth one of the motion phases of the plunger actuates a fourth operation selected from the group,
the fourth motion phase of the plunger is in the second direction, and
the electromechanical pumping assembly is arranged such that the third motion phase is before the fourth motion phase.
7. The apparatus according to claim 4 , wherein:
the plunger is coupled to the reservoir needle,
the first one of the motion phases is a maximal advance of the plunger in the first direction,
the first selected operation is driving the reservoir needle to penetrate the therapeutic substance reservoir, and
the plunger and the reservoir needle are arranged such that the maximal advance of the plunger drives the reservoir needle to penetrate the therapeutic substance reservoir.
8. The apparatus according to claim 7 , wherein the electromechanical pumping assembly is arranged such that following the first motion phase that is the maximal advance of the plunger in the first direction, no other motion phase that is an advance of the plunger in the first direction is an advance of the plunger as large as the maximal advance.
9. The apparatus according to claim 4 , wherein:
the second motion phase is a partial retraction of the plunger in the second direction, the partial retraction being less than a maximal retraction of the plunger in the second direction,
the second selected operation is advancing the body needle into the body of the subject, and
the plunger and the body needle injection mechanism are arranged such that the partial retraction of the plunger in the second direction causes the body needle injection mechanism to advance the body needle into the body of the subject.
10. The apparatus according to claim 9 , wherein the electromechanical pumping assembly is arranged such that the second motion phase actuates the operation of advancing the body needle into the body of the subject and the operation of withdrawing the therapeutic substance from the therapeutic substance reservoir.
11. The apparatus according to claim 4 , wherein:
the third one of the motion phases of the plunger is a partial advance of the plunger in the first direction,
the third selected operation is pumping the therapeutic substance into the subject, and
the electromechanical pumping assembly is arranged such that the partial advance of the plunger causes therapeutic substance inside the pump chamber to be pumped to the subject.
12. The apparatus according to claim 4 , wherein:
a fourth one of the motion phases of the plunger actuates a fourth operation selected from the group,
the fourth motion phase is a maximal retraction of the plunger in the second direction,
the fourth selected operation is retracting the body needle, and
the plunger and the body needle injection mechanism are arranged such that maximal retraction of the plunger causes the body needle injection mechanism to retract the body needle.
13. The apparatus according to claim 12 , wherein the electromechanical pumping assembly is arranged such that no other motion phase that is a retraction of the plunger in the second direction is a retraction of the plunger as large as the maximal retraction.
14. The apparatus according to claim 12 , wherein the plunger and the reservoir needle are arranged such that the maximal retraction of the plunger retracts the reservoir needle from the therapeutic substance reservoir.
15. The apparatus according to claim 1 , wherein the electromechanical pumping assembly is arranged such that the plurality of discrete motion phases sequentially actuate all of the operations in the group.
16. The apparatus according to claim 1 , wherein:
the body needle injection mechanism comprises a barrel cam coupled to (i) the body needle and (ii) a pretensioned torsion spring, and
the barrel cam is disposed within the therapeutic substance delivery device such that (a) as the pretensioned torsion spring is partially released the barrel cam rotates through a first rotational motion, the first rotational motion of the barrel cam advancing the body needle into the body of the subject, and (b) as the pretensioned torsion spring is further released the barrel cam rotates through a second rotational motion, the second rotational motion of the barrel cam retracting the body needle from the body of the subject.
17. The apparatus according to claim 16 , wherein the first rotational motion of the barrel cam is a rotation of the barrel cam through 45-135 degrees.
18. The apparatus according to claim 16 , wherein the second rotational motion of the barrel cam is a rotation of the barrel cam to 90-270 degrees from a starting position of the barrel cam.