Analyte sensor
Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into a host's peripheral vein or artery.
1. A system for measuring glucose in a host and delivering medication to the host, the system comprising:
a catheter configured for insertion into a host and configured to deliver medication to the host, wherein the catheter comprises an exterior surface;
a continuous glucose sensor disposed at least partially on the exterior surface of the catheter and including a reference electrode coiled about the catheter and a working electrode, wherein the continuous glucose sensor is configured to generate sensor data indicative of glucose concentration; and
sensor electronics operatively connected to the continuous glucose sensor, wherein the sensor electronics are configured to determine a glucose concentration.
2. The system of claim 1 , wherein the continuous glucose sensor is integrally formed on the exterior surface of the catheter.
3. The system of claim 1 , wherein the continuous glucose sensor is electroplated onto the exterior surface of the catheter.
4. The system of claim 1 , wherein the continuous glucose sensor comprises a membrane system covering at least a portion of the working electrode.
5. The system of claim 1 , wherein the working electrode comprises an exposed electroactive surface.
6. The system of claim 1 , wherein the catheter is configured to be operatively connected to an infusion pump.
7. The system of claim 6 , wherein in response to sensor data received from the continuous glucose sensor, the sensor electronics are configured to communicate a therapy recommendation to the infusion pump, wherein the therapy recommendation comprises information relating to insulin amount.
8. The system of claim 1 , wherein the continuous glucose sensor is configured to be used subcutaneously.
9. The system of claim 1 , wherein the sensor electronics are configured to substantially continuously determine the glucose concentration.
10. The system of claim 1 , wherein the catheter includes a fluid connector, and the reference electrode is coiled about the catheter adjacent to or within the fluid connector.
11. The system of claim 10 , wherein the reference electrode is positioned to be in contact with fluid flowing through the fluid connector.
12. The system of claim 10 , wherein the reference electrode is located remote from the working electrode.
13. The system of claim 12 , wherein the reference electrode is positioned to not be inserted into the host with the catheter.
14. The system of claim 1 , wherein the catheter is perforated, and at least a portion of the working electrode or the reference electrode is disposed within a lumen of the catheter.
15. The system of claim 1 , wherein the working electrode comprises a first working electrode configured to measure a first signal comprising glucose and baseline, and further comprising a second working electrode configured to measure a second signal comprising baseline and not glucose.
16. The system of claim 15 , wherein the sensor electronics are configured to produce a glucose signal based on the first signal and the second signal.
17. The system of claim 15 , wherein the sensor electronics are configured to subtract the second signal from the first signal to obtain a glucose-only signal.
18. The system of claim 1 , wherein the sensor electronics are configured to:
measure a current signal indicating the glucose concentration; and
continuously integrate the measured current signal.
19. The system of claim 1 , wherein the sensor electronics are configured to average a plurality of reference data points to calibrate the continuous glucose sensor.
20. The system of claim 19 , wherein the sensor electronics are configured to match an average of the plurality of reference data points with a plurality of sensor data points to form a matched data pair.