Compositions and methods for treating motor disorders
This invention provides methods utilizing ketamine for the treatment of motor disorders and/or side effects associated with certain medications used in the treatment of motor disorders. For example, in some embodiments, methods are provided for treating side effects associated with the administration of levodopa to a subject having Parkinson's disease, by administering a dose of ketamine or a pharmaceutically acceptable salt thereof. In particular, the invention provides methods for reducing dyskinesia associated with motor disorder (e.g., Parkinson's disease) treatments, and effective doses of ketamine or a pharmaceutically acceptable salt thereof.
1. A method of attenuating and/or treating a human patient suffering from levodopa induced dyskinesia, comprising administering to the patient two or more infusions within a ten-day period of a composition comprising a dose of ketamine or a pharmaceutically acceptable salt thereof to attenuate and/or ameliorate the symptoms of the levodopa induced dyskinesia,
wherein the dose of ketamine or pharmaceutically acceptable salt thereof is about 0.15 mg/kg/hour to about 2 mg/kg/hour,
wherein the duration of each infusion is approximately 60 minutes,
wherein administering the composition results in the patient experiencing chemical-induced deep brain stimulation,
wherein the chemical-induced deep brain stimulation results in attenuation and/or treating of the symptoms of the levodopa induced dyskinesia.
2. The method of claim 1 , further comprising administration of carbidopa.
3. The method of claim 1 , wherein the human subject is suffering from Parkinson's disease.
4. The method of claim 1 , wherein the within a ten-day period is within 72 hours.
5. The method of claim 1 , wherein ketamine is a metabolite of ketamine, wherein the metabolite of ketamine is selected from R-norketamine (NK), R-dehydronorketamine (DHK), S-norketamine (NK), S-dehydronorketamine (DHK), (2R,6R)-hydroxynorketamine (HNK), and (2S,6S)-hydroxynorketamine (HNK).