Cold slurry containment
The present invention provides methods and devices for controlling a cold slurry that is delivered to a target tissue and for limiting heat transferring from surrounding tissue to the target tissue. In particular, a balloon structure is deployed at or near a point of delivery to act as a physical and/or thermal barrier. In some instances, the balloon structure can act as a pressure device obstructing the flow of warm blood into a treatment area, which can melt the cold slurry.
1. A device for controlling tissue temperature, the device comprising:
a first cannula for delivering a cold slurry directly to a target tissue underneath a patient's skin, thereby directly contacting and cooling the target tissue, the first cannula comprising a first open distal end and a first proximal end in fluid communication with a source of cold slurry;
a second cannula comprising a second open distal end and a second proximal end in fluid communication with a source of a thermal insulator; and
a balloon disposed around the second open distal end of the second cannula and positioned at or near tissue surrounding the target tissue, the balloon comprising a volume filled with the thermal insulator delivered through the second cannula, wherein the filled balloon limits heat from transferring from the surrounding tissue to the target tissue.
2. The device of claim 1 , wherein the first and second cannulas each have a size and shape suitable for inserting through a subject's skin.
3. The device of claim 1 further comprising a cold slurry temperature monitor extending beyond the first open distal end to measure a temperature of the delivered cold slurry.
4. The device of claim 3 , wherein the cold slurry temperature monitor includes a temperature sensor at a distal end of the cold slurry temperature monitor.
5. The device of claim 4 , wherein the temperature sensor is a forward infrared (FIR) sensor.
6. The device of claim 3 , wherein the cold slurry temperature monitor includes a plurality of temperature sensors spaced along a length of the cold slurry temperature monitor.
7. The device of claim 1 , wherein the thermal insulator is any one of fluid, gas, air, gel, and aerogel.
8. The device of claim 1 , wherein the cold slurry is a mixture of water and glycerol.
9. The device of claim 1 , wherein the balloon has a length that is greater than its width.
10. The device of claim 1 , wherein the balloon is generally spherical.
11. The device of claim 1 , wherein the balloon has a longitudinal axis and is concaved as defined by a point along a line parallel to and offset from the longitudinal axis.
12. The device of claim 1 further comprising a guide, the guide comprising a working channel sized to house the second cannula and the balloon disposed around the second cannula; and
wherein the balloon is deployed from the working channel when in use.
13. The device of claim 1 , wherein the balloon has a linear shape.
14. The device of claim 1 , wherein the balloon has a ring shape.
15. The device of claim 1 , wherein the second cannula is configured to be insertable through the patient's skin.
16. The device of claim 1 , wherein the balloon has a plurality of projecting arms.
17. The device of claim 1 , wherein the balloon has a plurality of chambers which can be opened or closed to control the shape of the balloon.
18. The device of claim 1 , wherein the balloon has a plurality of chambers, each of which is filled with a gas or a fluid.
19. The device of claim 18 , wherein the temperatures of the gas or the fluid in each of the plurality of chambers of the balloon are different.