Bispecific T cell activating antigen binding molecules
The present invention generally relates to bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.
1. A T cell activating bispecific antigen-binding molecule comprising:
(a) the polypeptide sequence of SEQ ID NO: 376, the polypeptide sequence of SEQ ID NO: 377, and the polypeptide sequence of SEQ ID NO: 378; or
(b) the polypeptide encoded by the nucleic acid sequence of SEQ ID NO: 386, the polypeptide encoded by the nucleic acid sequence of SEQ ID NO: 387, and the polypeptide encoded by the nucleic acid sequence of SEQ ID NO: 388.