Immunosuppressive composition for use in treating immunological disorders
A pharmaceutical composition comprising at least one antibody and at least one mesenchymal stromal cell-derived protein, use of the pharmaceutical composition for treating immunological diseases, for example alloimmune and autoimmune diseases, and use of the pharmaceutical composition for immunomodulation.
1. A pharmaceutical composition comprising at least one antibody and at least one mesenchymal stromal cell-derived protein,
wherein the antibody targets CCL24 (Eotaxin-2); and
wherein the mesenchymal stromal cell-derived protein is CXCL5 (ENA-78).
2. The pharmaceutical composition of claim 1 , wherein the antibody is present in a concentration of about 0.05 μg/ml to about 5 μg/ml.
3. The pharmaceutical composition of claim 2 , wherein the antibody is present in a concentration of about 1 μg/ml or about 2 μg/ml.
4. The pharmaceutical composition of claim 1 , wherein the mesenchymal stromal cell-derived protein is present in a concentration of about 0.5 ng/ml to about 75 ng/ml.
5. The pharmaceutical composition of claim 4 , wherein the mesenchymal stromal cell-derived protein is present in a concentration of about 10 ng/ml or 50 ng/ml.
6. A kit comprising the pharmaceutical composition of claim 1 .