Protacs targeting coronavirus 3CL protease and preparation method and application thereof
A compound of formula I or formula II, a pharmaceutically acceptable salt, or a tautomer thereof is disclosed. The Linker is or and n is 1-6.
1. A compound of formula I or formula II, a pharmaceutically acceptable salt, or a tautomer thereof:
wherein, the Linker is
or
n and n is 1-6.
2. The compound of claim 1 , wherein the compound is selected from the group consisting of:
3. The compound of claim 1 , wherein the pharmaceutically acceptable salt comprises one selected from the group consisting of hydrochloric acid, hydrobromic acid, sulfuric acid, nitric acid, phosphoric acid, acetic acid, fumaric acid, maleic acid, oxalic acid, malonic acid, succinic acid, citric acid, malic acid, methanesulfonic acid, ethanesulfonic acid, benzenesulfonic acid, toluenesulfonic acid, glutamic acid, and aspartic acid.
4. An anti-coronavirus pharmaceutical preparation comprising the compound of claim 1 .
5. The anti-coronavirus pharmaceutical preparation of claim 4 , wherein the coronavirus is novel coronavirus SARS-CoV-2.