Isoindolines as HDAC inhibitors

1. A compound of Formula I:

and pharmaceutically acceptable salts thereof, wherein:

i) Z is N, and X 1 and X 2 are each, independently, at each occurrence, —CR 1 R 2 —, ═CR 1 —, or —C(O)—, as valency permits, provided that only one of X 1 and X 2 is —C(O)—; or

ii) Z is C or CH, X 1 is NR 3 , and X 2 is —CR 1 R 2 —, ═CR 1 —, or —C(O)—, as valency permits; or

iii) Z is C or CH, X 1 is —CR 1 R 2 —, ═CR 1 —, or —C(O)—, as valency permits, and X 2 is NR 3 ;

the dotted line between Z X 1 and Z X 2 is absent or represents a bond, provided that, at most, only one of the dotted lines represents a bond;

Y 1 , Y 2 , and Y 3 are each CR 1 ;

L is a bond, —(CR 1 R 2 ) p —, —C(O)NR 3 —, —NR 3 C(O)—, —O(CR 1 R 2 ) p C(O)—, —C(O)(CR 1 R 2 ) p O—, —(CR 1 R 2 ) p C(O)—, or —C(O)(CR 1 R 2 ) p —;

R is —C 4 -C 8 cycloalkenyl, —C 3 -C 8 cycloalkyl, heterocyclyl, aryl, or heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O, wherein each cycloalkenyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is optionally substituted with one or more substituents selected from the group consisting of —OH, halogen, oxo, —NO 2 , —CN, —R 1 , —R 2 , —SR 3 ,—OR 3 , —NHR 3 , —NR 3 R 4 , —S(O) 2 NR 3 R 4 , —S(O) 2 R 1 , —C(O)R 1 , —C(O)OR 1 , —NR 3 S(O) 2 R 1 , —S(O)R 1 , —S(O)NR 3 R 4 , and —NR 3 S(O)R 1 ;

R 1 and R 2 are independently, at each occurrence, —H, —R 3 , —R 4 , —C 1 -C 6 alkyl, —C 2 -C 6 alkenyl, —C 4 -C 8 cycloalkenyl, —C 2 -C 6 alkynyl, —C 3 -C 8 cycloalkyl, heterocyclyl, aryl, heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P and O, —OH, halogen, —NO 2 , —CN, —NHC 1 -C 6 alkyl, —N(C 1 -C 6 alkyl) 2 , —S(O) 2 N(C 1 -C 6 alkyl) 2 , —N(C 1 -C 6 alkyl)S(O) 2 R 5 , —S(O) 2 (C 1 -C 6 alkyl), —(C 1 -C 6 alkyl)S(O) 2 R 5 , —C(O)C 1 -C 6 alkyl, —C(O)OC 1 -C 6 alkyl, —N(C 1 -C 6 alkyl)S(O) 2 C 1 -C 6 alkyl, or —(CHR 5 ) p NR 3 R 4 , wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is optionally substituted with one or more substituents selected from the group consisting of —OH, halogen, —NO 2 , oxo, —CN, —R 5 , —OR 3 , —NHR 3 , —NR 3 R 4 , —S(O) 2 N(R 3 ) 2 —, —S(O) 2 R 5 , —C(O)R 5 , —C(O)OR 5 , —NR 3 S(O) 2 R 5 , —S(O)R 5 , —S(O)NR 3 R 4 , —NR 3 S(O)R 5 , heterocyclyl, aryl, and heteroaryl;

or R 1 and R 2 can combine with the carbon atom to which they are both attached to form a spirocycle, spiroheterocycle, or spirocycloalkenyl, each optionally substituted with one or more independent occurrences of R 3 and R 4 ;

or R 1 and R 2 , when on adjacent atoms, can combine to form a cycloalkyl, a heterocycle, a heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P and O, or a cycloalkenyl, each optionally substituted with one or more independent occurrences of R 3 and R 4 ;

or R 1 and R 2 , when on non-adjacent atoms, can combine to form an optionally bridging cycloalkyl, an optionally bridging heterocycle, or an optionally bridging cycloalkenyl, each optionally substituted with one or more independent occurrences of R 3 and R 4 ;

R 3 and R 4 are independently, at each occurrence, —H, —C 1 -C 6 alkyl, —C 2 -C 6 alkenyl, —C 4 -C 8 cycloalkenyl, —C 2 -C 6 alkynyl, —C 3 -C 8 cycloalkyl, heterocyclyl, aryl, heteroaryl containing 1-5 heteroatoms selected from N, S, P, and O, —S(O) 2 N(C 1 -C 6 alkyl) 2 , —S(O) 2 (C 1 -C 6 alkyl), —(C 1 -C 6 alkyl)S(O) 2 R 5 , —C(O)C 1 -C 6 alkyl, —C(O)OC 1 -C 6 alkyl, or —(CHR 5 ) p N(C 1 -C 6 alkyl) 2 , wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is optionally substituted with one or more substituents selected from the group consisting of —OH, halogen, —NO 2 , oxo, —CN, —R 5 , —O(C 1 -C 6 )alkyl, —NH(C 1 -C 6 )alkyl, —N(C 1 -C 6 alkyl)2, —S(O) 2 N(C 1 -C 6 alkyl) 2 , —S(O) 2 NHC 1 -C 6 alkyl, —C(O)C 1 -C 6 alkyl, —C(O)OC 1 -C 6 alkyl, —N(C 1 -C 6 alkyl)S(O) 2 C 1 -C 6 alkyl, —S(O)R 5 , —S(O)N(C 1 -C 6 alkyl) 2 , —N(C 1 -C 6 alkyl)S(O)R 5 , heterocyclyl, aryl, and heteroaryl;

R 5 is independently, at each occurrence, —H, —C 1 -C 6 alkyl, —C 2 -C 6 alkenyl, —C 4 -C 8 cycloalkenyl, —C 2 -C 6 alkynyl, —C 3 -C 8 cycloalkyl, heterocyclyl, aryl, heteroaryl containing 1-5 heteroatoms selected from N, S, P and O, —OH, halogen, —NO 2 , —CN, —NHC 1 -C 6 alkyl, —N(C 1 -C 6 alkyl) 2 , —S(O) 2 NH(C 1 -C 6 alkyl), —S(O) 2 N(C 1 -C 6 alkyl) 2 , —S(O) 2 C 1 -C 6 alkyl, —C(O)C 1 -C 6 alkyl, —C(O)OC 1 -C 6 alkyl, —N(C 1 -C 6 alkyl)SO 2 C 1 -C 6 alkyl, —S(O)(C 1 -C 6 alkyl), —S(O)N(C 1 -C 6 alkyl) 2 , —N(C 1 -C 6 alkyl)S(O)(C 1 -C 6 alkyl) or —(CH 2 ) p N(C 1 -C 6 alkyl) 2 ; and

p is 0, 1, 2, 3, 4, 5, or 6;

provided that when X 2 is —C(O)—, X 1 is CH 2 , Y 1 , Y 2 and Y 3 are each CH, and L is a bond, then R is a group other than substituted or unsubstituted phenyl; and

provided that the compound is not:

2. The compound of claim 1 , wherein the compound is selected from one of:

3. The compound of claim 1 , wherein L is a bond.

4. The compound of claim 1 , wherein L is —C(O)—.

5. The compound of claim 1 , wherein L is —(CR 1 R 2 ) p —, —C(O)NR 3 —, —NR 3 C(O)—,—C(O)(CR 1 R 2 ) p O—, or —(CR 1 R 2 ) p C(O)—, wherein p is 1 or 2.

6. The compound of claim 1 , wherein the compound has Formula II-A-i, II-A-ii, II-B-i, II-B-ii, II-C-i, II-C-ii, II-D-i, II-D-ii, II-E-i, II-E-ii, II-F-i, or II-F-ii:

7. The compound of claim 1 , wherein R is heterocyclyl, aryl, or heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, or O, wherein each heterocyclyl, aryl, or heteroaryl is optionally substituted with one or more —OH, halogen, oxo, —NO 2 , —CN, —R 1 , —R 2 , —SR 3 , —OR 3 , —NHR 3 , —NR 3 R 4 , —S(O) 2 NR 3 R 4 , —S(O) 2 R 1 , —C(O)R 1 , —C(O)OR 1 , —NR 3 S(O) 2 R 1 , —S(O)R 1 , —S(O)NR 3 R 4 , —NR 3 S(O)R 1 , heterocyclyl, aryl, or heteroaryl.

8. The compound of claim 1 , wherein R is heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, or O, wherein the heteroaryl is optionally substituted with one or more —OH, halogen, oxo, —NO 2 , —CN, —R 1 , —R 2 , —SR 3 , —OR 3 , —NHR 3 , —NR 3 R 4 , —S(O) 2 NR 3 R 4 , —S(O) 2 R 1 , —C(O)R 1 , —C(O)OR 1 , —NR 3 S(O) 2 R 1 , —S(O)R 1 , —S(O)NR 3 R 4 , —NR 3 S(O)R 1 , heterocyclyl, aryl, or heteroaryl.

9. The compound of claim 1 , wherein R is aryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, or O, wherein the aryl is optionally substituted with one or more —OH, halogen, oxo, —NO 2 , —CN, —R 1 , —R 2 , —SR 3 , —OR 3 , —NHR 3 , —NR 3 R 4 , —S(O) 2 NR 3 R 4 , —S(O) 2 R 1 , —C(O)R 1 , —C(O)OR 1 , —NR 3 S(O) 2 R 1 , —S(O)R 1 , —S(O)NR 3 R 4 , —NR 3 S(O)R 1 , heterocyclyl, aryl, or heteroaryl.

10. The compound of claim 1 , wherein R is phenyl containing 1-5 heteroatoms selected from the group consisting of N, S, P, or O, wherein the phenyl is optionally substituted with one or more —OH, halogen, oxo, —NO 2 , —CN, —R 1 , —R 2 , —SR 3 , —OR 3 , —NHR 3 , —NR 3 R 4 , —S(O) 2 NR 3 R 4 , —S(O) 2 R 1 , —C(O)R 1 , —C(O)OR 1 , —NR 3 S(O) 2 R 1 , —S(O)R 1 , —S(O)NR 3 R 4 , —NR 3 S(O)R 1 , heterocyclyl, aryl, or heteroaryl.

11. The compound of claim 1 , wherein R is a group selected from:

12. The compound of claim 1 , wherein:

i) Z is N, and X 1 and X 2 are each, independently, at each occurrence, —CR 1 R 2 —, ═CR 1 —, or —C(O)—, as valency permits, provided that only one of X 1 and X 2 is —C(O)—; or

ii) Z is C or CH, X 1 is NR 3 , and X 2 is —CR 1 R 2 —, ═CR 1 —, or —C(O)—, as valency permits;

or

iii) Z is C or CH, X 1 is —CR 1 R 2 —, ═CR 1 —, or —C(O)—, as valency permits, and X 2 is NR 3 ;

the dotted line between Z X 1 and Z X 2 is absent or represents a bond, provided that, at most, only one of the dotted lines represents a bond;

Y 1 , Y 2 , and Y 3 are each CR 1 ;

L is a bond, —(CR 1 R 2 ) p —, —C(O)NR 3 —, —NR 3 C(O)—, —(CR 1 R 2 ) p C(O)—, or —C(O)(CR 1 R 2 ) p —;

R is —C 3 -C 8 cycloalkyl, heterocyclyl, aryl, or heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O, wherein each cycloalkyl, heterocyclyl, aryl, or heteroaryl is optionally substituted with one or more substituents selected from the group consisting of —OH, —R 1 , —R 2 , and —OR 3

R 1 and R 2 are independently, at each occurrence, —H, —C 1 -C 6 alkyl, or aryl, wherein each alkyl or aryl is optionally substituted with one or more substituents selected from the group consisting of halogen and —OR 3 ;

or R 1 and R 2 , when on adjacent atoms, can combine to form a cycloalkyl or a heterocycle, each optionally substituted with one or more independent occurrences of R 3 and R 4 ;

R 3 and R 4 are independently, at each occurrence, —H, —C 1 -C 6 alkyl, or —C(O)C 1 -C 6 alkyl, wherein each alkyl is optionally substituted with one or more halogen; and

p is 0 or 1.

13. The compound of claim 1 , wherein:

Z is N;

X 1 and X 2 are each —CR 1 R 2 —;

the dotted line between Z X 1 and Z X 2 is absent;

Y 1 , Y 2 , and Y 3 are each CR 1 ;

L is a bond;

R is a 5- to 10-membered heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O, wherein heteroaryl is optionally substituted with one or more —R 1 and —R 2 ;

R 1 and R 2 are independently, at each occurrence, —H or —C 1 -C 6 alkyl, wherein each alkyl is optionally substituted with one or more halogen;

or R 1 and R 2 , when on adjacent atoms, can combine to form a cycloalkyl.

14. The compound of claim 1 having the structure:

Example

Structure

Name

 1-1

N-hydroxy-2-(6-(trifluoromethyl)- 4,5,6,7-tetrahydro-1H- benzo[d]imidazol-2-yl)isoindoline-4- carboxamide

 1-2

2-(4,5-dimethyl-1H-imidazol-2-yl)-N- hydroxyisoindoline-4-carboxamide

 1-3

N-hydroxy-2-(5-propyl-1H-imidazol-2- yl)isoindoline-4-carboxamide

 1-4

N-hydroxy-2-(4,5,6,7-tetrahydro-1H- benzo[d]imidazol-2-yl)isoindoline-4- carboxamide

 1-5

2-(6,6-dimethyl-4,5,6,7-tetrahydro-1H- benzo[d]imidazol-2-yl)-N- hydroxyisoindoline-4-carboxamide

 1-6

2-(1H-benzo[d]imidazol-2-yl)-N- hydroxyisoindoline-4-carboxamide

 2-1

(R)-N-hydroxy-2-(6-(trifluoromethyl)- 4,5,6,7-tetrahydro-1H- benzo[d]imidazol-2-yl)isoindoline-4- carboxamide

 2-2

(S)-N-hydroxy-2-(6-(trifluoromethyl)- 4,5,6,7-tetrahydro-1H- benzo[d]imidazol-2-yl)isoindoline-4- carboxamide

 3-1

N-hydroxy-2-(3H-imidazo[4,5-c]pyridin- 2-yl)isoindoline-4-carboxamide

 4-1

N-hydroxy-2-(3H-imidazo[4,5- b]pyridin-2-yl)isoindoline-4- carboxamide

 5-1

N-hydroxy-2-(oxazolo[4,5-b]pyridin-2- yl)isoindoline-4-carboxamide

 5-2

N-hydroxy-2-(oxazolo[5,4-c]pyridin-2- yl)isoindoline-4-carboxamide

 6-1

N-hydroxy-2-(oxazolo[4,5-c]pyridin-2- yl)isoindoline-4-carboxamide

 6-2

N-hydroxy-2-(oxazolo[5,4-b]pyridin-2- yl)isoindoline-4-carboxamide

 7-1

N-hydroxy-2-(quinazolin-2- yl)isoindoline-4-carboxamide

 7-2

N-hydroxy-2-(quinolin-2-yl)isoindoline- 4-carboxamide

 7-3

N-hydroxy-2-(1,5-naphthyridin-2- yl)isoindoline-4-carboxamide

 7-4

2-(benzo[d]thiazol-2-yl)-N- hydroxyisoindoline-4-carboxamide

 7-5

N-hydroxy-2-(5-methyl-1H-imidazol-2- yl)isoindoline-4-carboxamide

 8-1

N-hydroxy-2-(1,5-naphthyridin-3- yl)isoindoline-4-carboxamide

 9-1

2-(3,4-dihydro-2H-benzo[b][1,4]oxazin- 7-yl)-N-hydroxyisoindoline-4- carboxamide

 9-2

2-(3,4-dihydro-2H-benzo[b][1,4]oxazin- 6-yl)-N-hydroxyisoindoline-4- carboxamide

10-1

N-hydroxy-2-(thiazolo[4,5-b]pyridin-2- yl)isoindoline-4-carboxamide

11-1

N-hydroxy-2-(5- (trifluoromethyl)benzo[d]thiazol-2- yl)isoindoline-4-carboxamide

12-1

N-hydroxy-2-(6-(trifluoromethyl)-1H- benzo[d]imidazol-2-yl)isoindoline-4- carboxamide

13-1

N-hydroxy-2-(4,5,6,7-tetrahydro-3H- imidazo[4,5-c]pyridin-2-yl)isoindoline- 4-carboxamide

14-1

2-(5-acetyl-4,5,6,7-tetrahydro-3H- imidazo[4,5-c]pyridin-2-yl)-N- hydroxyisoindoline-4-carboxamide

15-1

2-(benzo[d]oxazol-2-yl)-N- hydroxyisoindoline-4-carboxamide

16-1

N-hydroxy-2-(5-(trifluoromethyl)- 4,5,6,7-tetrahydrobenzo[d]oxazol-2- yl)isoindoline-4-carboxamide

18-1

N-hydroxy-1,1-dimethyl-2-(5- (trifluoromethyl)benzo[d]oxazol-2- yl)isoindoline-4-carboxamide

18-2

N-hydroxy-1,1-dimethyl-2- (oxazolo[4,5-b]pyridin-2-yl)isoindoline- 4-carboxamide

18-3

N-hydroxy-1,1-dimethyl-2-(6- (trifluoromethyl)benzo[d]oxazol-2- yl)isoindoline-4-carboxamide

19-1

N-hydroxy-1,1-dimethyl-2-(5- (trifluoromethyl)-4,5,6,7- tetrahydrobenzo[d]oxazol-2- yl)isoindoline-4-carboxamide

19-2

N-hydroxy-1,1-dimethyl-2-(6- (trifluoromethyl)-4,5,6,7- tetrahydrobenzo[d]oxazol-2- yl)isoindoline-4-carboxamide

20-1

N-hydroxy-1,1-dimethyl-2- (thiazolo[4,5-b]pyridin-2-yl)isoindoline- 4-carboxamide

20-2

N-hydroxy-1,1-dimethyl-2-(5- (trifluoromethyl)benzo[d]thiazol-2- yl)isoindoline-4-carboxamide

21-1

N-hydroxy-1,1-dimethyl-2- (oxazolo[4,5-c]pyridin-2-yl)isoindoline- 4-carboxamide

22-1

2-(benzo[d]thiazol-2-yl)-N-hydroxy-1,1- dimethylisoindoline-4-carboxamide

22-2

N-hydroxy-1,1-dimethyl-2-(5- (trifluoromethyl)pyridin-2- yl)isoindoline-4-carboxamide

22-3

N-hydroxy-1,1-dimethyl-2-(6- (trifluoromethyl)pyridin-3- yl)isoindoline-4-carboxamide

22-4

N-hydroxy-1,1-dimethyl-2-(1,5- naphthyridin-2-yl)isoindoline-4- carboxamide

22-5

N-hydroxy-1,1-dimethyl-2-(quinolin-2- yl)isoindoline-4-carboxamide

22-6

N-hydroxy-1,1-dimethyl-2-(5- (trifluoromethyl)pyrimidin-2- yl)isoindoline-4-carboxamide

22-7

N-hydroxy-1,1-dimethyl-2-(2- (trifluoromethyl)pyrimidin-5- yl)isoindoline-4-carboxamide

22-9

N-hydroxy-1,1-dimethyl-2-(4- (trifluoromethyl)thiazol-2- yl)isoindoline-4-carboxamide

23-1

N-hydroxy-1,1-dimethyl-2-(6- (trifluoromethyl)quinolin-2- yl)isoindoline-4-carboxamide

23-2

N-hydroxy-1,1-dimethyl-2-(7- (trifluoromethyl)quinolin-2- yl)isoindoline-4-carboxamide

24-1

N-hydroxy-1,1-dimethyl-2-(6- (trifluoromethyl)-1,5-naphthyridin-2- yl)isoindoline-4-carboxamide

25-1

2-(benzo[d]oxazol-2-yl)-N-hydroxy-1,1- dimethylisoindoline-4-carboxamide

26-1

N-hydroxy-1,1-dimethyl-2-(5- (trifluoromethyl)oxazolo[4,5-b]pyridin- 2-yl)isoindoline-4-carboxamide

26-2

N-hydroxy-1,1-dimethyl-2-(6- (trifluoromethyl)oxazolo[4,5-b]pyridin- 2-yl)isoindoline-4-carboxamide

27-1

2-(6-cyano-5-(trifluoromethyl)pyridin- 2-yl)-N-hydroxy-1,1- dimethylisoindoline-4-carboxamide

27-2

2-(4-cyano-5-(trifluoromethyl)pyridin- 2-yl)-N-hydroxy-1,1- dimethylisoindoline-4-carboxamide

28-1

N-hydroxy-1,1-dimethyl-2-(4- (trifluoromethyl)benzoyl)isoindoline-4- carboxamide

28-2

N-hydroxy-1,1-dimethyl-2-(3- (trifluoromethyl)benzoyl)isoindoline-4- carboxamide

29-1

N4-hydroxy-1,1-dimethyl-N2-(4- (trifluoromethyl)phenyl)isoindoline- 2,4-dicarboxamide

30-1

N4-hydroxy-1,1-dimethyl-N2-(6- (trifluoromethyl)pyridin-3- yl)isoindoline-2,4-dicarboxamide

30-2

N4-hydroxy-1,1-dimethyl-N2-(5- (trifluoromethyl)pyridin-2- yl)isoindoline-2,4-dicarboxamide

30-3

N4-hydroxy-1,1-dimethyl-N2-(2- (trifluoromethyl)pyridin-4- yl)isoindoline-2,4-dicarboxamide

30-4

N4-hydroxy-1,1-dimethyl-N2-(5- (trifluoromethyl)pyridin-3- yl)isoindoline-2,4-dicarboxamide

30-5

N4-hydroxy-1,1-dimethyl-N2-(4- (trifluoromethyl)pyridin-2- yl)isoindoline-2,4-dicarboxamide

30-6

N4-hydroxy-1,1-dimethyl-N2-(6- (trifluoromethyl)pyridin-2- yl)isoindoline-2,4-dicarboxamide

30-7

N2-(benzo[d]oxazol-2-yl)-N4-hydroxy- 1,1-dimethylisoindoline-2,4- dicarboxamide

31-1

N4-hydroxy-1,1-dimethyl-N2-(5,6,7,8- tetrahydroisoquinolin-3-yl)isoindoline- 2,4-dicarboxamide

32-1

N-hydroxy-2-(4-methoxybenzyl)-1,1- dimethylisoindoline-4-carboxamide

34-1

N-hydroxy-2-(6-phenyl-5- (trifluoromethyl)-1H-benzo[d]imidazol- 2-yl)isoindoline-4-carboxamide

35-1

N-hydroxy-2-(7-phenyl-5- (trifluoromethyl)-1H-benzo[d]imidazol- 2-yl)isoindoline-4-carboxamide

35-2

N-hydroxy-2-(7-phenyl-1H- benzo[d]imidazol-2-yl)isoindoline-4- carboxamide

36-1

2-(benzo[d]oxazol-2-yl)-N-hydroxy-1- oxoisoindoline-4-carboxamide

37-1

N-hydroxy-2-(4- (trifluoromethyl)phenyl)-1H-indole-7- carboxamide

37-2

N-hydroxy-2-(4- (trifluoromethyl)phenyl)-1H-indole-4- carboxamide

37-3

N-hydroxy-2-(5- (trifluoromethyl)pyrazin-2-yl)-1H- indole-7-carboxamide

37-4

N-hydroxy-2-(5- (trifluoromethyl)pyrazin-2-yl)-1H- indole-4-carboxamide

38-1

N-hydroxy-2-(4- (trifluoromethyl)phenyl)indoline-7- carboxamide

38-2

N-hydroxy-2-(4- (trifluoromethyl)phenyl)indoline-4- carboxamide

39-1

(R)-N-hydroxy-2-(4- (trifluoromethyl)phenyl)indoline-7- carboxamide

39-2

(S)-N-hydroxy-2-(4- (trifluoromethyl)phenyl)indoline-7- carboxamide

40-1

(R)-N-hydroxy-3,3-dimethyl-2-(5- (trifluoromethyl)pyridin-2-yl)indoline- 7-carboxamide

40-2

(S)-N-hydroxy-3,3-dimethyl-2-(5- (trifluoromethyl)pyridin-2-yl)indoline- 7-carboxamide

40-3

(R)-N-hydroxy-3,3-dimethyl-2-(5- (trifluoromethyl)pyrazin-2-yl)indoline- 7-carboxamide

40-4

(S)-N-hydroxy-3,3-dimethyl-2-(5- (trifluoromethyl)pyrazin-2-yl)indoline- 7-carboxamide

40-5

(S)-N-hydroxy-3,3-dimethyl-2-(4- (trifluoromethyl)phenyl)indoline-7- carboxamide

40-6

(R)-N-hydroxy-3,3-dimethyl-2-(4- (trifluoromethyl)phenyl)indoline-7- carboxamide

 1-6

2-(1H-benzo[d]imidazol-2-yl)-N- hydroxyisoindoline-4-carboxamide

 1-7

N-hydroxy-2-(1-(2-methoxyethyl)-1H- benzo[d]imidazol-2-yl)isoindoline-4- carboxamide

28-3

N-hydroxy-2-(2-(4- methoxyphenyl)butanoyl)isoindoline- 4-carboxamide

41-1

2-benzoyl-N-hydroxyisoindoline-4- carboxamide

41-2

N-hydroxy-2-(4- methoxybenzyl)isoindoline-4- carboxamide

42-1

N-hydroxy-2-phenylisoindoline-4- carboxamide

44-1

N-hydroxy-2-(4-hydroxy-5-phenyl-4- (trifluoromethyl)-4H-imidazol-2- yl)isoindoline-4-carboxamide

45-1

N-hydroxy-2-(5- (trifluoromethyl)pyridin-2- yl)isoindoline-4-carboxamide

45-2

N-hydroxy-2-(6- (trifluoromethyl)pyridin-2- yl)isoindoline-4-carboxamide

36-2

N-hydroxy-1-oxo-2-(5- (trifluoromethyl)benzo[d]oxazol-2- yl)isoindoline-4-carboxamide; or

43-1

N-hydroxy-2-((1s,4s)-4- (trifluoromethyl)cyclohexyl)isoindoline- 4-carboxamide.

15. A pharmaceutical composition comprising a compound of claim 1 and a pharmaceutically acceptable carrier.

16. A pharmaceutical composition comprising a compound of claim 14 and a pharmaceutically acceptable carrier.