Snuff composition
Use of a nicotine-cellulose combination for the preparation of a snuff composition for achievement of a fast onset of action of nicotine after application of the snuff composition to the oral cavity of a subject, wherein the composition has a high release rate so that when subjected to an in vitro dissolution test about 45% or more of the total content of nicotine is released within 30 minutes. Moreover, the invention relates to an improved snuff composition for application to the oral cavity.
1. A product for delivery of an oral composition, the product comprising:
(a) a composition that includes:
a cellulose material; and
nicotine, at least a portion of the nicotine being sorbed to at least a portion of the cellulose material so as to be in the form a nicotine-cellulose combination and such that the nicotine-cellulose combination forms at least 45% by weight of the total weight of the composition; and (b) a pouch enclosing the composition.
2. The product of claim 1 , wherein the nicotine-cellulose combination forms at least 80% to 98% by weight of the total weight of the composition.
3. The product of claim 1 , wherein the nicotine is nicotine free base or a pharmaceutically acceptable salt, solvate, complex, or derivative thereof.
4. The product of claim 1 , wherein the nicotine is in the form of a nicotine salt.
5. The product of claim 4 , wherein the nicotine salt is nicotine bitartrate.
6. The product of claim 1 , wherein the nicotine is present in a total amount of about 0.5 mg to about 10 mg.
7. The product of claim 1 , wherein the composition includes a further cellulose in addition to the cellulose material.
8. The product of claim 1 , wherein the composition includes at least one sugar alcohol.
9. The product of claim 8 , wherein the sugar alcohol includes maltitol.
10. The product of claim 1 , wherein the composition includes at least one artificial sweetener.
11. The product of claim 10 , wherein the at least one artificial sweetener includes acesulfame.
12. The product of claim 1 , wherein the composition includes one or both of sodium carbonate and sodium hydrogen carbonate.
13. The product of claim 1 , wherein the composition includes at least one flavoring.
14. The product of claim 1 , wherein the nicotine and the cellulose material are combined such that, when subjected to an in vitro dissolution test using UV detection, about 30% or more of the total content of the nicotine is released from the composition within 30 minutes.
15. The product of claim 1 , wherein the pouch is formed of cellulose.
16. The product of claim 1 , wherein at least a portion of the nicotine is absorbed into at least a portion of the cellulose material.
17. The product of claim 1 , wherein at least a portion of the nicotine is adsorbed onto at least a portion of the cellulose material.
18. A product for delivery of an oral composition, the product comprising:
(a) a composition that includes:
a cellulose material;
nicotine in a total amount of about 0.5 mg to about 10 mg, at least a portion of the nicotine being sorbed to at least a portion of the cellulose material so as to be in the form a nicotine-cellulose combination and such that the nicotine-cellulose combination forms at least 45% by weight of the total weight of the composition;
one or both of sodium carbonate and sodium bicarbonate;
one or more sweeteners; and
one or more flavorings; and
(b) a pouch enclosing the composition;
wherein the nicotine and the cellulose material are combined such that, when subjected to an in vitro dissolution test using UV detection, about 30% or more of the total content of the nicotine is released from the composition within 30 minutes.
19. The product of claim 18 , wherein the nicotine-cellulose combination forms at least 80% to 98% by weight of the total weight of the composition.
20. The product of claim 18 , wherein the nicotine is nicotine free base or a pharmaceutically acceptable salt, solvate, complex, or derivative thereof.
21. The product of claim 18 , wherein the nicotine is in the form of a nicotine salt.
22. The product of claim 21 , wherein the nicotine salt is nicotine bitartrate.
23. The product of claim 18 , wherein the composition includes a further cellulose in addition to the cellulose material.
24. The product of claim 18 , wherein the nicotine and the cellulose material are combined such that, when subjected to an in vitro dissolution test using UV detection, about 45% or more of the total content of the nicotine is released from the composition within 20 minutes.
25. The product of claim 18 , wherein the pouch is formed of cellulose.
26. A product for delivery of a composition to an oral cavity, the product comprising:
(a) a composition that includes:
a cellulose material;
nicotine bitartrate in a total amount of about 1.5 mg to about 7.5 mg, at least a portion of the nicotine bitartrate being sorbed to at least a portion of the cellulose material so as to be in the form a nicotine-cellulose combination and such that the nicotine-cellulose combination forms at least 45% by weight of the total weight of the composition;
one or both of sodium carbonate and sodium bicarbonate;
one or more sweeteners including at least maltitol and acesulfame; and
one or more flavorings; and
(b) a pouch enclosing the composition.
27. The product of claim 26 , wherein the nicotine bitartrate and the cellulose material are combined such that, when subjected to an in vitro dissolution test using UV detection, about 30% or more of the total content of the nicotine is released from the composition within 30 minutes.
28. The product of claim 26 , wherein the nicotine-cellulose combination forms at least 80% to 98% by weight of the total weight of the composition.
29. The product of claim 26 , wherein the pouch is formed of cellulose.