Glutamate agents in the treatment of mental disorders
Methods of treating mental disorders, including anxiety disorders such as obsessive-compulsive disorder, are provided. The methods comprise administering an effective amount of a glutamate modulator to an individual in need thereof. Also provided are methods of enhancing the activity of a serotonin reuptake inhibitor (SRI) comprising co-administering a glutamate modulator and a serotonin reuptake inhibitor. Pharmaceutical composition comprising a serotonin reuptake inhibitor and a glutamate modulator are also provided.
1. A method of treating a mental disorder in an individual in need thereof comprising administering to said individual an effective amount of riluzole alone in pharmaceutical dosage form, wherein said mental disorder is post-traumatic stress disorder.
2. The method according to claim 1 wherein said riluzole is administered in oral dosage form.