IP Library › Granted Patent US 11,612,644
Granted Patent B2
US 11,612,644 · App. 16/936,396 · Granted Mar 28, 2023

Cell population for use in treating cancer

Inventors: Jolanda De Vries (Nijmegen, NL); Carl Figdor (Nijmegen, NL); Ghaith Bakdash (Nijmegen, NL)
Assignee: MILTENYI BIOTEC B.V. & CO. KG
A61K39/0011A61K35/15C12N5/0639A61K2035/124A61K2039/5154A61K2039/57A61K2039/585
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Quick Facts
Patent No.
US 11,612,644
App. No.
16/936,396
Granted
Mar 28, 2023
Kind
B2
Abstract

The invention pertains to a cell population for use in treating cancer in a patient, comprising CD1c (BDCA-1) + /CD19 − dendritic cells, wherein CD1c(BDCA-1) + /CD19 − dendritic cells are depleted for CD1c (BDCA-1) + /CD19 − /CD14 + cells.

Claims (6)

1. A method for treating cancer, comprising administering a cell population of CD1c+/CD19-myeloid dendritic cells to a patient diagnosed with cancer, wherein less than or equal to 25% of the CD1c+/CD19− dendritic cells are CD1c+/CD19−/CD14+ cells.

2. The method of claim 1 , wherein the cancer is a solid cancer or a blood cancer.

3. The method of claim 1 , wherein the cancer is a chronic myeloid leukemia.

4. The method of claim 1 , wherein the cancer is a melanoma.

5. The method of claim 1 , wherein the cancer is a prostate cancer.

6. The method of claim 1 , wherein the cell population further comprises cells that are CD304+(BDCA-4+) plasmacytoid dendritic cells.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 6, 2020
From: MILTENYI BIOTEC GMBH
To: MILTENYI BIOTEC B.V. & CO. KG
Reel/Frame 053989/0343 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 4, 2020
From: MILTENYI BIOTEC GMBH
To: MILTENYI BIOTEC B.V. & CO. KG
Reel/Frame 054106/0235 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 22, 2020
From: DE VRIES, JOLANDA; FIGDOR, CARL; BAKDASH, GHAITH
To: MILTENYI BIOTEC GMBH
Reel/Frame 053285/0941 →
Priority Claims (3)
EP 14184333 · Sep 10, 2014 · regional
EP 14184334 · Sep 10, 2014 · regional
EP 14184687 · Sep 12, 2014 · regional
Continuity (2)
Division 15510222
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