Deep topical systemic nitric oxide therapy apparatus and method
A topical mixture that produces nitric oxide and a method for using the topical mixture to increase the vasodilation of a bloodstream via transdermal absorption of the nitric oxide. The nitric oxide can then affect subcutaneous tissues. The systemic vasodilation of a mammal may be increased via a topical application of an appropriate nitric oxide producing substance.
1. A composition for increasing systemic vasodilation in a mammal with an epidermal surface and a bloodstream having an initial systemic vasodilation of the bloodstream, comprising:
a first topical medium comprising a nitrite compound in a first container, wherein the first container comprises a systemic vasodilation dose of the first topical medium configured on reaction to release an amount of nitric oxide topically to a mammal that is configured to increase the systemic vasodilation of the mammal;
a second topical medium comprising at least two reducing agents in a second container, wherein the second container comprises a systemic vasodilation dose of the second topical medium configured on reaction to release an amount of nitric oxide topically to a mammal that is configured to increase the systemic vasodilation of the mammal; and
wherein the first container comprises a first dispenser for topical application of the systemic vasodilation dose of the first topical medium, and the second container comprises a second dispenser for topical application of the systemic vasodilation dose of the second topical medium, wherein the systemic vasodilation dose of the first topical medium and the systemic vasodilation dose of the second topical medium are dispensed from their respective first and second dispensers and mixed into a systemic vasodilation mixture by a user during use, thereby initiating production of nitric oxide in an effective amount such that application of the systemic vasodilation mixture onto a first location of an epidermal surface of a mammal is configured to deliver at least 500 ppm of nitric oxide transdermally within 10 minutes after the application, thereby increasing the systemic vasodilation of the bloodstream at a second, untreated location of the mammal as compared to the initial systemic vasodilation during use.
2. The composition of claim 1 , wherein the epidermal surface is healthy skin.
3. The composition of claim 1 , wherein the systemic vasodilation mixture of the first topical medium and the second topical medium, in use, includes a salt buffer concentration for prolonging the production of nitric oxide, wherein the salt used in the salt buffer includes at least one salt selected from a group consisting of sodium chloride and calcium chloride.
4. The composition of claim 1 , wherein the systemic vasodilation mixture is adapted for treating the mammal for a symptom of peripheral artery disease.
5. The composition of claim 1 , wherein the first topical medium includes at least sodium nitrite.
6. The composition of claim 1 , wherein the first topical medium includes at least potassium nitrite.
7. The composition of claim 1 , wherein the second topical medium includes at least two reducing agents selected from a group consisting of citric acid, ascorbic acid, phytic acid, acetic acid, formic acid, and lactic acid.
8. The composition of claim 1 , wherein the first and second topical mediums further include a thickening agent.
9. The method of claim 1 , wherein the first topical medium further comprises sodium bicarbonate.
10. A composition for treating a systemic disorder, comprising:
a first topical medium comprising a nitrite compound in a first container, wherein the first container comprises a systemic vasodilation dose of the first topical medium configured on reaction to release an amount of nitric oxide topically to a subject that is configured to increase the systemic vasodilation of the subject;
a second topical medium comprising a reducing agent in a second container, wherein the second container comprises a systemic vasodilation dose of the second topical medium suitable on reaction to release an amount of nitric oxide topically to a subject that is configured to increase the systemic vasodilation of the subject; and
wherein the systemic vasodilation dose of the first topical medium and the systemic vasodilation dose of the second topical medium are mixed into a systemic vasodilation mixture by a user during use, thereby initiating production of nitric oxide in an effective amount such that application of the systemic vasodilation mixture onto a first location of an epidermal treatment surface of a subject is configured to increase systemic vasodilation of the bloodstream at a second, unapplied location of the subject to treat the systemic disorder during use.
11. The composition of claim 10 , wherein application of the systemic vasodilation mixture is adapted to treat symptoms of the systemic disorder peripheral artery disease.
12. The composition of claim 10 , wherein the second topical medium includes at least two reducing agents selected from a group consisting of citric acid, ascorbic acid, phytic acid, acetic acid, formic acid, and lactic acid.
13. The composition of claim 10 , wherein the systemic vasodilation mixture includes sodium chloride.
14. The composition of claim 10 , wherein the systemic vasodilation mixture includes calcium chloride.
15. A composition for increasing vasodilation in a subject comprising:
a first topical medium comprising a nitrite compound in a first container, wherein the first container comprises a systemic vasodilation dose of the first topical medium configured on reaction to release an amount of nitric oxide topically to a subject that is configured to increase the systemic vasodilation of the subject;
a second topical medium comprising a reducing agent in a second container, wherein the second container comprises a systemic vasodilation dose of the second topical medium suitable on reaction to release an amount of nitric oxide topically to a subject that is configured to increase the systemic vasodilation of the subject; and
wherein the systemic vasodilation dose of the first topical medium and the systemic vasodilation dose of the second topical medium are mixed into a systemic vasodilation mixture by a user during use, wherein the systemic vasodilation dose of the first topical medium and the systemic vasodilation dose of the second topical medium are configured such that the systemic vasodilation mixture includes a salt for prolonging the production of nitric oxide, wherein during use the systemic vasodilation mixture is configured to initiate production of nitric oxide such that application of the systemic vasodilation mixture onto a first location of a treatment surface of a subject is configured to deliver an effective amount of nitric oxide transdermally, and to increase the systemic vasodilation of the bloodstream at a second, untreated location of the subject as compared to the initial systemic vasodilation during use.
16. The composition of claim 15 , wherein the second topical medium comprises citric acid.
17. The composition of claim 15 , wherein the second topical medium comprises ascorbic acid.
18. The composition of claim 15 , wherein the second topical medium comprises phytic acid.
19. The composition of claim 15 , wherein the second topical medium comprises acetic acid.
20. The composition of claim 15 , wherein the second topical medium comprises formic acid.
21. The composition of claim 15 , wherein the second topical medium comprises lactic acid.