Antimicrobial peptide stimulating cleansing composition
A topical cleansing composition for stimulating the production of antimicrobial peptides on the skin is disclosed. The topical cleansing composition includes an active ingredient comprising one or more of a natural extract and a polypeptide; one or more surfactants; and water. The topical cleansing composition increases the concentration of antimicrobial peptides on skin, as compared to an otherwise identical topical composition without the active ingredient.
1. A cleansing composition comprising:
an active ingredient, the active ingredient comprising a linseed extract, wherein the active ingredient is present in an amount up to 5 wt. %;
from 3 wt. % to 13 wt. % of one or more primary surfactants comprising sodium laureth sulfate;
one or more foaming agents; and
at least 70 wt. % of water,
wherein each wt. % is based upon the total weight of the cleansing composition.
2. The cleansing composition of claim 1 , wherein the active ingredient is present in an amount up to 1 wt. %, based upon the total weight of the cleansing composition.
3. The cleansing composition of claim 1 , wherein the one or more primary surfactants consist of anionic surfactants.
4. The cleansing composition of claim 3 , wherein the one or more foaming agents are selected from the group consisting of betaines.
5. The cleansing composition of claim 1 , wherein the cleansing composition increases the concentration of antimicrobial peptides on skin, as compared to an otherwise identical cleansing composition without the active ingredient.
6. The cleansing composition of claim 5 , wherein the cleansing composition increases the concentration of HBD-1 by at least 10%, relative to an otherwise identical cleansing composition without the active ingredient.
7. The cleansing composition of claim 5 , wherein the cleansing composition increases the concentration of HBD-2 by at least 5%, relative to an otherwise identical cleansing composition without the active ingredient.
8. The cleansing composition of claim 5 , wherein the cleansing composition increases the concentration of HBD-3 by at least 5%, relative to an otherwise identical cleansing composition without the active ingredient.
9. The cleansing composition of claim 5 , wherein the cleansing composition increases the concentration of LL-37 by at least 5%, relative to an otherwise identical cleansing composition without the active ingredient.
10. The cleansing composition of claim 5 , wherein the cleansing composition decreases the concentration of IL-8 by at least 5%, relative to an otherwise identical cleansing composition without the active ingredient.