Pharmaceutical compositions and methods for treating hypertension
Disclosed herein are compositions and methods for delivering cannabidiol to subject in need of hypertension treatment. The disclosed compositions are orally delivered. Further disclosed are kits comprising the disclosed compositions as part of a method of delivering the cannabidiol-containing compositions.
1. A composition for treating hypertension, consisting of:
a) from about 5% to about 20% by weight of cannabidiol;
b) from about 15% to about 60% by weight of olive oil or high oleic acid olive oil;
c) from about 20% to about 80% by weight one or more carriers chosen from tapioca starch, tapioca flour, mannitol, microcrystalline cellulose, colloidal silicon dioxide, or mixtures thereof and
d) from about 0.5% to about 5% of a bile salt.
2. The composition according to claim 1 , consisting of from about 10% to about 15% by weight of cannabidiol.
3. The composition according to claim 1 , consisting of from about 10% to about 45% by weight of olive oil or high oleic acid olive oil.
4. The composition according to claim 1 , wherein the bile salt is selected from cholic acid, cholate, deoxycholic acid, deoxycholate, hyodeoxycholic acid, hyodeoxycholate, glycocholic acid, glycocholate, taurocholic acid, taurocholate, chenodeoxycholic acid, chenodeoxycholate, lithocholic acid and lithocholate.
5. A composition for treating hypertension, consisting of:
a) from about 50 mg to about 100 mg by weight of cannabidiol;
b) from about 50 mg to about 300 mg by weight of olive oil or high oleic acid olive oil; and
c) from about 200 mg to about 400 mg by weight of one or more carriers chosen from tapioca starch, tapioca flour, mannitol, microcrystalline cellulose, colloidal silicon dioxide, or mixtures thereof and
d) from about 1 mg to about 10 mg by weight of one or more bile salts.
6. The composition according to claim 5 , consisting of from about 60 mg to about 90 mg by weight of cannabidiol.
7. The composition according to claim 5 , wherein the bile salt is selected from cholic acid, cholate, deoxycholic acid, deoxycholate, hyodeoxycholic acid, hyodeoxycholate, glycocholic acid, glycocholate, taurocholic acid, taurocholate, chenodeoxycholic acid, chenodeoxycholate, lithocholic acid, lithocolate, and mixtures thereof.
8. The composition according to claim 7 , wherein the bile salt is deoxycholic acid.
9. A composition for treating hypertension, consisting of:
a) from about 5% to about 20% by weight of CBD oil;
b) from about 5% to about 60% by weight of olive oil or high oleic acid olive oil;
c) from about 20% to about 80% by weight of one or more carriers chosen from tapioca starch, tapioca flour, mannitol, microcrystalline cellulose, colloidal silicon dioxide, or mixtures thereof; and
d) from about 0.5% to about 5% of a bile salt.
10. The composition according to claim 9 , consisting of from about 10% to about 15% by weight of CBD oil.
11. The composition according to claim 9 , consisting of from about 15% to about 30% by weight of olive oil or high oleic acid olive oil.
12. The composition according to claim 9 , wherein the bile salt is selected from deoxycholic acid, taurocholate, glycocholic acid or mixtures thereof.
13. A method for treating hypertension in a subject in need of treatment, comprising administering to the subject a composition consisting of:
a) from about 5% to about 20% by weight of cannabidiol;
b) from about 15% to about 60% by weight of olive oil or high oleic acid olive oil;
c) from about 20% to about 80% by weight one or more carriers chosen from tapioca starch, tapioca flour, mannitol, microcrystalline cellulose, colloidal silicon dioxide, or mixtures thereof and
d) from about 0.5% to about 5% of a bile salt.
14. The method according to claim 13 , the composition consisting of from about 10% to about 15% by weight of cannabidiol.
15. The method according to claim 13 , the composition consisting of from about 10% to about 45% by weight of olive oil or high oleic acid olive oil.
16. The method according to claim 13 , wherein the bile salt is selected from deoxycholic acid, taurocholate acid, glycocholic acid, or mixtures thereof.